AT157108B - Process for the preparation of 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids. - Google Patents

Process for the preparation of 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids.

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Publication number
AT157108B
AT157108B AT157108DA AT157108B AT 157108 B AT157108 B AT 157108B AT 157108D A AT157108D A AT 157108DA AT 157108 B AT157108 B AT 157108B
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AT
Austria
Prior art keywords
allyl
isobutyl
ethyl
preparation
thiobarbituric acids
Prior art date
Application number
Other languages
German (de)
Original Assignee
Ig Farbenindustrie Ag
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Publication date
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Publication of AT157108B publication Critical patent/AT157108B/en

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Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von 5-Äthyl- bzw. 5-Allyl-5-isobutyl-2-thiobarbitursäuren. 



   Es wurde gefunden, dass man zu den in der Patentschrift Nr.   155904 beschriebenen 5-Äthyl-   bzw.   5-Allyl-5-isobutyl-2-thiobarbitursäuren auch   in der Weise gelangen kann, dass man in üblicher Weise hergestellten   2-Thiobarbitursäuren,   die in 5-Stellung durch einen der angegebenen Reste substituiert sind, nach an sich   üblichen   Arbeitsweisen, z. B. mit Hilfe umsetzungsfähiger Ester entsprechender Alkohole, beispielsweise mittels der Halogenwasserstoffsäure-,   Schwefelsäure-oder   Sulfonsäureester, den fehlenden zweiten Rest einführt. 
 EMI1.1 
 trockenes Benzol und 8 g Allylbromid werden im   Schüttelrohr   4 Stunden auf   1000 erhitzt. Dann   saugt man ab, wäscht die Salze mit warmem Benzol nach und verdampft das Benzol.

   Der   Rückstand   aus dem Benzol wird in Essigester gelöst und mit Petroläther die   5-Isobutyl-5-allyl-2-thiobarbitursäure   vom F =   146-0 gefällt. Man   kann die Umsetzung auch bei Gegenwart eines Katalysators, z. B. etwas Kupferbronze, vornehmen. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids.



   It has been found that the 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids described in patent specification No. 155904 can also be obtained in such a way that 2-thiobarbituric acids prepared in the usual way, which are substituted in the 5-position by one of the radicals indicated, according to conventional procedures, e.g. B. with the help of reactive esters of corresponding alcohols, for example by means of the hydrohalic acid, sulfuric acid or sulfonic acid ester, introduces the missing second residue.
 EMI1.1
 dry benzene and 8 g of allyl bromide are heated to 1000 for 4 hours in a shaker tube. It is then filtered off with suction, the salts are washed with warm benzene and the benzene is evaporated.

   The residue from the benzene is dissolved in ethyl acetate and 5-isobutyl-5-allyl-2-thiobarbituric acid with a melting point of 146-0 is precipitated with petroleum ether. The reaction can also be carried out in the presence of a catalyst, e.g. B. make some copper bronze.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung von 5-Äthyl-bzw. 5-Allyl-5-isobutyl-2-thiobarnitursäuren, dadurch gekennzeichnet, dass man in nach üblicher Weise hergestellten, in 5-Stellung durch einen der angegebenen Reste substituierten 2-Thiobarbitursäuren den fehlenden zweiten Rest einführt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of 5-ethyl or. 5-Allyl-5-isobutyl-2-thiobarbituric acids, characterized in that the missing second radical is introduced in 2-thiobarbituric acids which are substituted in the 5-position by one of the radicals indicated and which are prepared in a conventional manner. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT157108D 1935-11-28 1936-11-05 Process for the preparation of 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids. AT157108B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE157108X 1935-11-28

Publications (1)

Publication Number Publication Date
AT157108B true AT157108B (en) 1939-09-25

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ID=5678353

Family Applications (1)

Application Number Title Priority Date Filing Date
AT157108D AT157108B (en) 1935-11-28 1936-11-05 Process for the preparation of 5-ethyl- or 5-allyl-5-isobutyl-2-thiobarbituric acids.

Country Status (1)

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AT (1) AT157108B (en)

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