AT500379B8 - Tau-proteine - Google Patents

Tau-proteine Download PDF

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Publication number
AT500379B8
AT500379B8 AT0017501A AT1752001A AT500379B8 AT 500379 B8 AT500379 B8 AT 500379B8 AT 0017501 A AT0017501 A AT 0017501A AT 1752001 A AT1752001 A AT 1752001A AT 500379 B8 AT500379 B8 AT 500379B8
Authority
AT
Austria
Prior art keywords
tau
tau proteins
normal
proteins
conformationally different
Prior art date
Application number
AT0017501A
Other languages
English (en)
Other versions
AT500379A2 (de
AT500379B1 (de
AT500379A3 (de
Original Assignee
Axon Neuroscience
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0017501A priority Critical patent/AT500379B8/de
Application filed by Axon Neuroscience filed Critical Axon Neuroscience
Priority to ES02703586T priority patent/ES2339427T3/es
Priority to CNB028053133A priority patent/CN100503638C/zh
Priority to DE60235746T priority patent/DE60235746D1/de
Priority to AU2002237296A priority patent/AU2002237296A1/en
Priority to JP2002563203A priority patent/JP4163955B2/ja
Priority to DK02703586.4T priority patent/DK1355949T3/da
Priority to AT02703586T priority patent/ATE461941T1/de
Priority to PCT/EP2002/000897 priority patent/WO2002062851A1/en
Priority to US10/470,928 priority patent/US7446180B2/en
Priority to CNA2008101081547A priority patent/CN101307107A/zh
Priority to EP02703586A priority patent/EP1355949B1/de
Priority to RU2003126594/13A priority patent/RU2299889C2/ru
Priority to CA2437453A priority patent/CA2437453C/en
Publication of AT500379A2 publication Critical patent/AT500379A2/de
Priority to US12/264,694 priority patent/US20090123936A1/en
Publication of AT500379A3 publication Critical patent/AT500379A3/de
Application granted granted Critical
Publication of AT500379B1 publication Critical patent/AT500379B1/de
Publication of AT500379B8 publication Critical patent/AT500379B8/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT0017501A 2001-02-02 2001-02-02 Tau-proteine AT500379B8 (de)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AT0017501A AT500379B8 (de) 2001-02-02 2001-02-02 Tau-proteine
CNA2008101081547A CN101307107A (zh) 2001-02-02 2002-01-29 tau蛋白
DE60235746T DE60235746D1 (de) 2001-02-02 2002-01-29 Antikörper gegen Alzheimer spezifische tau Proteine mit abnormaler Konformation
AU2002237296A AU2002237296A1 (en) 2001-02-02 2002-01-29 Conformationally abnormal forms of tau proteins and specific antibodies thereto
JP2002563203A JP4163955B2 (ja) 2001-02-02 2002-01-29 構造的に異常な形のタウタンパク質およびそれに対する特異抗体
DK02703586.4T DK1355949T3 (da) 2001-02-02 2002-01-29 Antistoffer mod konformationelt abnorme former af tau-protein der forekommer i væv ved Alzheimers sygdom
AT02703586T ATE461941T1 (de) 2001-02-02 2002-01-29 Antikörper gegen alzheimer spezifische tau proteine mit abnormaler konformation
PCT/EP2002/000897 WO2002062851A1 (en) 2001-02-02 2002-01-29 Conformationally abnormal forms of tau proteins and specific antibodies thereto
ES02703586T ES2339427T3 (es) 2001-02-02 2002-01-29 Anticuerpos contra formas conformacionalmente anormales de proteina tau presente en tejidos con enfermedad de alzheimer.
CNB028053133A CN100503638C (zh) 2001-02-02 2002-01-29 tau蛋白
EP02703586A EP1355949B1 (de) 2001-02-02 2002-01-29 Antikörper gegen Alzheimer spezifische tau Proteine mit abnormaler Konformation
RU2003126594/13A RU2299889C2 (ru) 2001-02-02 2002-01-29 Конформационно аномальные формы белков тау и специфические антитела к ним
CA2437453A CA2437453C (en) 2001-02-02 2002-01-29 Conformationally abnormal forms of tau proteins and specific antibodies thereto
US10/470,928 US7446180B2 (en) 2001-02-02 2002-01-29 Conformationally abnormal forms of tau proteins and specific antibodies thereto
US12/264,694 US20090123936A1 (en) 2001-02-02 2008-11-04 Conformationally abnormal forms of tau proteins and specific antibodies thereto

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0017501A AT500379B8 (de) 2001-02-02 2001-02-02 Tau-proteine

Publications (4)

Publication Number Publication Date
AT500379A2 AT500379A2 (de) 2005-12-15
AT500379A3 AT500379A3 (de) 2009-02-15
AT500379B1 AT500379B1 (de) 2009-07-15
AT500379B8 true AT500379B8 (de) 2009-08-15

Family

ID=3658236

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0017501A AT500379B8 (de) 2001-02-02 2001-02-02 Tau-proteine
AT02703586T ATE461941T1 (de) 2001-02-02 2002-01-29 Antikörper gegen alzheimer spezifische tau proteine mit abnormaler konformation

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02703586T ATE461941T1 (de) 2001-02-02 2002-01-29 Antikörper gegen alzheimer spezifische tau proteine mit abnormaler konformation

Country Status (12)

Country Link
US (2) US7446180B2 (de)
EP (1) EP1355949B1 (de)
JP (1) JP4163955B2 (de)
CN (2) CN101307107A (de)
AT (2) AT500379B8 (de)
AU (1) AU2002237296A1 (de)
CA (1) CA2437453C (de)
DE (1) DE60235746D1 (de)
DK (1) DK1355949T3 (de)
ES (1) ES2339427T3 (de)
RU (1) RU2299889C2 (de)
WO (1) WO2002062851A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
WO2004007722A2 (en) * 2002-07-12 2004-01-22 Axon Neuroscience Forschungs- Und Entwicklungs Gmbh Transgenic animal expressing alzheimer’s tau protein
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
ES2321996B1 (es) * 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias.
US8012936B2 (en) * 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
WO2009143556A1 (en) * 2008-05-30 2009-12-03 The University Of Sydney TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION
EP4218794A3 (de) * 2009-06-10 2023-09-13 New York University Immunologisches targeting pathologischer tau-proteine
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
EP2470211B1 (de) * 2009-08-28 2016-01-27 The Board of Regents of The University of Texas System Tau-oligomere bindende antikörper
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
WO2011130377A2 (en) 2010-04-15 2011-10-20 Abbott Laboratories Amyloid-beta binding proteins
ITRM20100320A1 (it) 2010-06-11 2011-12-11 Consiglio Nazionale Ricerche Metodo per la diagnostica e il trattamento delle taupatie
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
LT2627672T (lt) 2010-10-11 2018-12-10 Biogen International Neuroscience Gmbh Žmogaus antikūnai prieš tau baltymą
CA2817973C (en) 2010-10-15 2019-06-25 The Board Of Regents Of The University Of Texas System Antibodies that bind amyloid oligomers
WO2012106363A2 (en) 2011-01-31 2012-08-09 Intellect Neurosciences Inc. Treatment of tauopathies
WO2012162179A1 (en) * 2011-05-20 2012-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
EP3275461A1 (de) * 2011-09-19 2018-01-31 Axon Neuroscience SE Proteinbasierte therapie und diagnose von tau-vermittelter pathologie im bereich von morbus alzheimer
JP6358953B2 (ja) 2011-10-07 2018-07-18 エーシー イミューン エス．エー． タウを認識するホスホ特異的抗体
EP2870176A4 (de) 2012-07-03 2016-09-28 Univ Washington Anti-tau-antikörper
EP2885010B1 (de) 2012-08-16 2020-01-01 Ipierian, Inc. Verfahren zur behandlung einer tauopathie
US9200068B2 (en) * 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
JP6284548B2 (ja) 2012-12-21 2018-02-28 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． ヒト抗タウ抗体
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
WO2014165271A2 (en) 2013-03-13 2014-10-09 Neotope Biosciences Limited Tau immunotherapy
MX374811B (es) * 2013-03-15 2025-03-06 Ac Immune Sa Anticuerpos anti-tau y métodos de uso.
CR20160270A (es) 2013-12-20 2016-09-05 Hoffmann La Roche ANTICUERPOS ANTI-TAU (pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN
CN105939722A (zh) 2014-02-14 2016-09-14 伊皮埃里安股份有限公司 Tau肽，抗Tau抗体，及其使用方法
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
TWI734975B (zh) * 2014-06-27 2021-08-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
EP3166688B1 (de) 2014-07-08 2024-08-21 New York University Tau-bildgebungsliganden und deren verwendung in der diagnose und behandlung von tauopathie
AR103713A1 (es) 2015-02-26 2017-05-31 Lilly Co Eli Anticuerpos contra tau y sus usos
NZ775762A (en) * 2015-06-05 2025-02-28 Genentech Inc Anti-tau antibodies and methods of use
ES2809728T3 (es) 2015-06-24 2021-03-05 Hoffmann La Roche Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso
SG10202010735PA (en) 2015-07-06 2020-11-27 UCB Biopharma SRL Tau-binding antibodies
US10988528B2 (en) 2015-08-13 2021-04-27 New York University Antibody-based molecules specific for the truncated ASP421 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
EP3452507B1 (de) 2016-05-02 2022-10-19 Prothena Biosciences Limited Tau-immuntherapie
MX2018013384A (es) 2016-05-02 2019-02-28 Prothena Biosciences Ltd Anticuerpos que reconocen tau.
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JP6949102B2 (ja) 2016-08-09 2021-10-13 イーライ リリー アンド カンパニー 併用療法
EP3551220B1 (de) 2016-12-07 2025-01-29 Genentech, Inc. Anti-tau antikörper und derern verwendung
EP3551655A2 (de) 2016-12-07 2019-10-16 Genentech, Inc. Anti-tau-antikörper und verfahren zu deren verwendung
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CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
CN107686839B (zh) * 2017-09-25 2020-12-04 安徽朵能生物科技有限公司 微管结合蛋白cript、其治疗性突变体及其应用
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KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
TWI859197B (zh) 2019-03-03 2024-10-21 愛爾蘭商普羅帝納生物科學公司 識別ｔａｕ之抗體
EP4317950B1 (de) 2019-03-18 2026-01-28 Regeneron Pharmaceuticals, Inc. Crispr/cas-screening-plattform zur identifizierung genetischer modifikatoren von tau-impfung oder -aggregation
CN113874078B (zh) 2019-04-05 2025-05-06 Tauc3生物制品有限公司 抗tauc3抗体及其应用
GB2585252A (en) 2019-07-05 2021-01-06 Gen2 Neuroscience Ltd Tau epitope and binding molecules
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
US20240101654A1 (en) 2020-12-29 2024-03-28 Neurimmune Ag Human anti-tau antibodies
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
JPH06239899A (ja) 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
US20020164657A1 (en) * 2001-02-23 2002-11-07 Sharma Satish K. Assays for assessing A beta-Tau aggregation

Also Published As

Publication number Publication date
CN1492879A (zh) 2004-04-28
ES2339427T3 (es) 2010-05-20
US20040082763A1 (en) 2004-04-29
EP1355949A1 (de) 2003-10-29
CN100503638C (zh) 2009-06-24
JP4163955B2 (ja) 2008-10-08
WO2002062851A8 (en) 2002-09-12
RU2299889C2 (ru) 2007-05-27
JP2004532817A (ja) 2004-10-28
CA2437453C (en) 2013-06-11
DK1355949T3 (da) 2010-05-25
CA2437453A1 (en) 2002-08-15
DE60235746D1 (de) 2010-05-06
CN101307107A (zh) 2008-11-19
AT500379A2 (de) 2005-12-15
ATE461941T1 (de) 2010-04-15
WO2002062851A1 (en) 2002-08-15
AT500379B1 (de) 2009-07-15
US20090123936A1 (en) 2009-05-14
AU2002237296A1 (en) 2002-08-19
EP1355949B1 (de) 2010-03-24
RU2003126594A (ru) 2005-03-10
US7446180B2 (en) 2008-11-04
AT500379A3 (de) 2009-02-15

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Effective date: 20210202