AT67206B - Process for the production of sera and vaccines. - Google Patents

Process for the production of sera and vaccines.

Info

Publication number
AT67206B
AT67206B AT67206DA AT67206B AT 67206 B AT67206 B AT 67206B AT 67206D A AT67206D A AT 67206DA AT 67206 B AT67206 B AT 67206B
Authority
AT
Austria
Prior art keywords
production
bacterial
sera
vaccines
excretions
Prior art date
Application number
Other languages
German (de)
Inventor
Otto Dr Med Stiner
Original Assignee
Otto Dr Med Stiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otto Dr Med Stiner filed Critical Otto Dr Med Stiner
Application granted granted Critical
Publication of AT67206B publication Critical patent/AT67206B/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

  

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 20 Minuten   der Bestrahlung einer Quocksilberdampfquarzlampe ausgesetzt   worden waren, ein   hochagglutinierendes,   komplementbindendes Serum gegen Tuberkulose zu erzeugen, in welchem 
 EMI2.1 
 bis zur   Auflösung   bestrahlt, so geben sie einen Teil ihrer Substanzen an die   8uspeusionsflüssigkeit   ab ; durch Injektion dieser   Suspensionsnüsaigkeit   wurde im Versuchstier ein Serum erzeugt, das nicht nur gegen Bakterienausscheidungen, sondern auch gegen die Endotoxine gerichtet ist. Durch weitere Bestrahlung kann diese Flüssigkeit überdies teilweise entgiftet und zur direkten Injektion zu Heilzwecken tauglich gemacht   werden.   



   Die Tuberkelbazillen verlieren bei der Bestrahlung einen Teil ihrer färbbaren Substanz, sowohl der Innensubstanz wie der Hülle, woraus eben zu entnehmen ist, dass sie diese Substanz an die   Suspensionsflüssigkeit   abgeben. Der gleiche Vorgang ist bei den Diphtheriebazillen zu beobachten ; sie werden bei Bestrahlung im Diphtherietoxin gezwungen, einen Teil ihrer Substanz an das Toxin abzugeben, gleichzeitig wird das Toxin durch die Bestrahlung teilweise entgiftet. 



  Durch Injektion der Suspensiollsflüssigkeit wird beim Versuchstier wie auch beim kranken Menschen ein Serum erzeugt werden können, das sowohl gegen die Bakterientoxine, wie gegen die Endotoxine gerichtet ist.



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 20 minutes of exposure to a quartz silver vapor lamp had been exposed to produce a highly agglutinating, complement-binding serum against tuberculosis, in which
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 irradiated until they dissolve, they give off part of their substances to the discharge fluid; By injecting this suspension liquid, a serum was generated in the test animal which is directed not only against bacterial excretions but also against endotoxins. Through further irradiation, this liquid can also be partially detoxified and made suitable for direct injection for healing purposes.



   The tubercle bacilli lose part of their colorable substance on irradiation, both the inner substance and the shell, from which it can be seen that they release this substance into the suspension fluid. The same process can be observed in diphtheria bacilli; When irradiated in the diphtheria toxin, they are forced to release part of their substance to the toxin, at the same time the toxin is partially detoxified by the irradiation.



  By injecting the suspension fluid, a serum can be generated in the test animal as well as in the sick person, which is directed against both the bacterial toxins and the endotoxins.

Claims (1)

PATENT. ANSPRUCH : Verfahren zur Erzeugung von Seren und Vakzinen. gekennzeichnet dadurch, dass die zur Herstellung dieser Arzneimittel verwendeten Bakterien, Bakteriensubstanzen oder Bakterienausscheidungen der Wirkung ultravioletter Strahlen ausgesetzt werden, zum Zwecke, durch kürzere oder längere Dauer der Bestrahlung eine Schwächung, Abtötung oder Aufschliessung der Bakterien bzw. eine Verminderung der Giftigkeit der Bakteriensubstanzen und Bakterienausscheidungen herbeizuführen. PATENT. CLAIM : Process for the production of sera and vaccines. characterized in that the bacteria, bacterial substances or bacterial excretions used for the production of these drugs are exposed to the action of ultraviolet radiation, for the purpose of weakening, killing or breaking down the bacteria or reducing the toxicity of the bacterial substances and bacterial excretions through shorter or longer exposure times bring about.
AT67206D 1913-06-21 1913-06-21 Process for the production of sera and vaccines. AT67206B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT67206T 1913-06-21

Publications (1)

Publication Number Publication Date
AT67206B true AT67206B (en) 1914-12-10

Family

ID=3589105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT67206D AT67206B (en) 1913-06-21 1913-06-21 Process for the production of sera and vaccines.

Country Status (1)

Country Link
AT (1) AT67206B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421382A (en) * 1946-03-06 1947-06-03 Michael Reese Res Foundation Vaccines and antigens and method of producing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421382A (en) * 1946-03-06 1947-06-03 Michael Reese Res Foundation Vaccines and antigens and method of producing the same

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