ATA141186A - Verfahren zur herstellung einer parenteralen t-pa-loesung - Google Patents

Verfahren zur herstellung einer parenteralen t-pa-loesung

Info

Publication number
ATA141186A
ATA141186A AT861411A AT141186A ATA141186A AT A141186 A ATA141186 A AT A141186A AT 861411 A AT861411 A AT 861411A AT 141186 A AT141186 A AT 141186A AT A141186 A ATA141186 A AT A141186A
Authority
AT
Austria
Prior art keywords
parenteral
producing
solution
Prior art date
Application number
AT861411A
Other languages
English (en)
Other versions
AT391812B (de
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521704A external-priority patent/GB8521704D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ATA141186A publication Critical patent/ATA141186A/de
Application granted granted Critical
Publication of AT391812B publication Critical patent/AT391812B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
AT0141186A 1985-05-28 1986-05-27 Verfahren zur herstellung einer parenteralen t-pa-loesung AT391812B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521704A GB8521704D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (2)

Publication Number Publication Date
ATA141186A true ATA141186A (de) 1990-06-15
AT391812B AT391812B (de) 1990-12-10

Family

ID=26289289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0141186A AT391812B (de) 1985-05-28 1986-05-27 Verfahren zur herstellung einer parenteralen t-pa-loesung

Country Status (22)

Country Link
US (1) US5112609A (de)
AT (1) AT391812B (de)
AU (1) AU569429B2 (de)
BE (1) BE904831A (de)
CA (1) CA1297008C (de)
CH (1) CH664495A5 (de)
DE (1) DE3617753A1 (de)
DK (1) DK163174C (de)
ES (1) ES8706443A1 (de)
FI (1) FI85334C (de)
FR (1) FR2593393B1 (de)
GB (1) GB2176703B (de)
GR (1) GR861365B (de)
HU (1) HU200695B (de)
IL (1) IL78937A (de)
IT (1) IT1191925B (de)
LU (1) LU86445A1 (de)
NL (1) NL8601354A (de)
NO (1) NO171344C (de)
NZ (1) NZ216306A (de)
PT (1) PT82647B (de)
SE (1) SE462893B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484A7 (fi) * 1982-05-05 1983-11-06 Genentech Inc Ihmiskudoksen plasminogeenien aktivaattori.
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
WO1986005096A1 (en) * 1985-03-06 1986-09-12 Survival Technology, Inc. Protein absorption enhancing agents
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
JPH0680015B2 (ja) * 1986-05-12 1994-10-12 ザ ウエルカム ファウンデーション リミテッド 医薬組成物
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
GB8814604D0 (en) * 1988-06-20 1988-07-27 Wellcome Found Medicaments
WO1990001334A1 (en) * 1988-08-05 1990-02-22 Codon Formulations for plasminogen activator using aspartate
GB8819607D0 (en) * 1988-08-17 1988-09-21 Wellcome Found Novel combination
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
GB9000629D0 (en) * 1990-01-11 1990-03-14 Porton Prod Ltd Tissue plasminogen activator
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
DE69719265T2 (de) * 1996-09-06 2003-12-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
HUE025670T2 (en) 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (de) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
ES8106836A2 (es) * 1979-07-27 1981-10-01 Fabre Sa Pierre Procedimiento de obtencion de un activador del plasminogeno
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
EP0124613B1 (de) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Neuer plasminogen-aktivator aus menschlichen nieren, dessen herstellungsverfahren und thrombolytisches arzneimittel, das diesen enthält
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
EP0112122B1 (de) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogenaktivator
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
DE59009964D1 (de) * 1989-09-13 1996-01-25 Rieter Ag Maschf Verfahren zum Starten eines Arbeitsablaufs eines Bedienungsautomaten an einer Textilmaschine

Also Published As

Publication number Publication date
IL78937A0 (en) 1986-09-30
ES555352A0 (es) 1987-07-01
NO171344C (no) 1993-03-03
SE8602404L (sv) 1986-11-29
LU86445A1 (fr) 1986-12-05
GB8612781D0 (en) 1986-07-02
FI85334B (fi) 1991-12-31
NO171344B (no) 1992-11-23
US5112609A (en) 1992-05-12
FI862226L (fi) 1986-11-29
AT391812B (de) 1990-12-10
GR861365B (en) 1986-09-29
IT8648064A0 (it) 1986-05-27
DK246886A (da) 1986-11-29
NO862095L (no) 1986-12-01
SE8602404D0 (sv) 1986-05-27
NL8601354A (nl) 1986-12-16
DE3617753A1 (de) 1986-12-04
DK246886D0 (da) 1986-05-27
FI862226A0 (fi) 1986-05-27
DE3617753C2 (de) 1988-06-30
GB2176703B (en) 1988-12-07
HU200695B (en) 1990-08-28
BE904831A (fr) 1986-11-27
FI85334C (fi) 1992-04-10
FR2593393B1 (fr) 1989-06-02
ES8706443A1 (es) 1987-07-01
SE462893B (sv) 1990-09-17
CA1297008C (en) 1992-03-10
CH664495A5 (de) 1988-03-15
FR2593393A1 (fr) 1987-07-31
PT82647A (en) 1986-06-01
DK163174B (da) 1992-02-03
AU5796586A (en) 1986-12-04
GB2176703A (en) 1987-01-07
HUT42330A (en) 1987-07-28
AU569429B2 (en) 1988-01-28
DK163174C (da) 1992-06-22
IT1191925B (it) 1988-03-31
IL78937A (en) 1990-11-29
NZ216306A (en) 1989-10-27
PT82647B (pt) 1989-01-30

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties