ATA147791A - Pharmazeutische pleuromutilin-zubereitung - Google Patents

Pharmazeutische pleuromutilin-zubereitung

Info

Publication number: ATA147791A
Authority: AT; Austria
Prior art keywords: pleuromutilin; pharmaceutical; preparation; cyclodextrin; complexes
Prior art date: 1991-07-24

Application number

AT0147791A

Other languages

English (en)

Other versions

AT400674B (de

Inventor

Erich Dr Zeisl

Heinrich Dr Matous

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-24

Filing date

1991-07-24

Publication date

1995-07-15

1991-07-24 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

1991-07-24 Priority to AT0147791A priority Critical patent/AT400674B/de

1992-07-13 Priority to HU9202307A priority patent/HU214589B/hu

1992-07-22 Priority to IL10259792A priority patent/IL102597A/en

1992-07-22 Priority to NZ243662A priority patent/NZ243662A/en

1992-07-22 Priority to FI923342A priority patent/FI104788B/fi

1992-07-22 Priority to BG96678A priority patent/BG61864B1/bg

1992-07-22 Priority to BR929202804A priority patent/BR9202804A/pt

1992-07-22 Priority to AU20536/92A priority patent/AU656987B2/en

1992-07-22 Priority to CA002074385A priority patent/CA2074385C/en

1992-07-22 Priority to NO922901A priority patent/NO300445B1/no

1992-07-23 Priority to SU925052221A priority patent/RU2099324C1/ru

1992-07-23 Priority to RO92-01019A priority patent/RO111680B1/ro

1992-07-23 Priority to SK2311-92A priority patent/SK280773B6/sk

1992-07-23 Priority to DK92112634.8T priority patent/DK0524632T3/da

1992-07-23 Priority to EP92112634A priority patent/EP0524632B1/de

1992-07-23 Priority to CS922311A priority patent/CZ281620B6/cs

1992-07-23 Priority to KR1019920013120A priority patent/KR100237719B1/ko

1992-07-23 Priority to MX9204318A priority patent/MX9204318A/es

1992-07-23 Priority to SG1996004628A priority patent/SG44633A1/en

1992-07-23 Priority to DE69221793T priority patent/DE69221793T2/de

1992-07-23 Priority to ES92112634T priority patent/ES2104775T3/es

1992-07-23 Priority to IE922392A priority patent/IE80625B1/en

1992-07-23 Priority to AT92112634T priority patent/ATE157260T1/de

1992-07-23 Priority to CN92108688A priority patent/CN1039319C/zh

1992-07-23 Priority to JP19666592A priority patent/JP3296847B2/ja

1992-07-24 Priority to ZA925600A priority patent/ZA925600B/xx

1992-07-25 Priority to TW081105891A priority patent/TW307770B/zh

1992-09-30 Priority to SA92130137A priority patent/SA92130137B1/ar

1995-03-10 Priority to US08/402,272 priority patent/US5578585A/en

1995-06-30 Priority to HU95P/P00678P priority patent/HU211650A9/hu

1995-07-15 Publication of ATA147791A publication Critical patent/ATA147791A/de

1996-02-26 Application granted granted Critical

1996-02-26 Publication of AT400674B publication Critical patent/AT400674B/de

1997-11-26 Priority to GR970403146T priority patent/GR3025497T3/el

Links

ZRZNJUXESFHSIO-UHFFFAOYSA-N Pleuromutilin Natural products CC1C(O)C(C)(C=C)CC(OC(=O)CO)C2(C)C(C)CCC31C2C(=O)CC3 ZRZNJUXESFHSIO-UHFFFAOYSA-N 0.000 title abstract 2
ZRZNJUXESFHSIO-VYTKZBNOSA-N pleuromutilin Chemical compound C([C@H]([C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]2C)OC(=O)CO)C)C[C@]32[C@H]1C(=O)CC3 ZRZNJUXESFHSIO-VYTKZBNOSA-N 0.000 title abstract 2
229920000858 Cyclodextrin Chemical group 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000003674 animal food additive Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000000536 complexating effect Effects 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
-1 pleuromutilin compound Chemical class 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
- C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
- C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT0147791A 1991-07-24 1991-07-24 Pharmazeutische pleuromutilin-zubereitung AT400674B (de)

Priority Applications (31)

Application Number	Priority Date	Filing Date	Title
AT0147791A AT400674B (de)	1991-07-24	1991-07-24	Pharmazeutische pleuromutilin-zubereitung
HU9202307A HU214589B (hu)	1991-07-24	1992-07-13	Eljárás pleuromutilinszármazék ciklodextrin komplexei és az ezeket tartalmazó gyógyszerkészítmények előállítására
NZ243662A NZ243662A (en)	1991-07-24	1992-07-22	Complex of pleuromutilin derivative and a cyclodextrin; pharmaceutical preparations
FI923342A FI104788B (fi)	1991-07-24	1992-07-22	Menetelmä pleuromutiliinikompleksin ja farmaseuttisen valmisteen valmistamiseksi
BG96678A BG61864B1 (bg)	1991-07-24	1992-07-22	Плевромутилинови комплекси,метод за получаванетоим и лекарствени средства,които ги съдържат
BR929202804A BR9202804A (pt)	1991-07-24	1992-07-22	Complexo e processo para sua preparacao,formulacao farmaceuticha e processo para sua preparacao
AU20536/92A AU656987B2 (en)	1991-07-24	1992-07-22	Pleuromutilin complexes
CA002074385A CA2074385C (en)	1991-07-24	1992-07-22	Pleuromutilin complexes
NO922901A NO300445B1 (no)	1991-07-24	1992-07-22	Kompleks omfattende et pleuromutilinderivat og farmasöytisk preparat omfattende dette kompleks
IL10259792A IL102597A (en)	1991-07-24	1992-07-22	Pleuromutilin complexes their preparation and pharmaceutical compositions containing them
IE922392A IE80625B1 (en)	1991-07-24	1992-07-23	Pleuromutilin complexes
SK2311-92A SK280773B6 (sk)	1991-07-24	1992-07-23	Komplex pleuromutilínového derivátu a cyklodextrín
DK92112634.8T DK0524632T3 (da)	1991-07-24	1992-07-23	Pleuromutilinkomplekser
EP92112634A EP0524632B1 (de)	1991-07-24	1992-07-23	Pleuromotuline Komplexe
SU925052221A RU2099324C1 (ru)	1991-07-24	1992-07-23	Комплекс производного плевромутилина, способ его получения, фармацевтическая композиция его содержащая
KR1019920013120A KR100237719B1 (ko)	1991-07-24	1992-07-23	플루로머틸린 착체 및 이를 함유하는 약제학적 제제
MX9204318A MX9204318A (es)	1991-07-24	1992-07-23	Complejos de derivados de pleuromutilina para su preparacion y composiciones farmaceuticas que los contienen.
SG1996004628A SG44633A1 (en)	1991-07-24	1992-07-23	Pleuromutilin complexes
DE69221793T DE69221793T2 (de)	1991-07-24	1992-07-23	Pleuromotuline Komplexe
ES92112634T ES2104775T3 (es)	1991-07-24	1992-07-23	Complejos de pleuromutilina.
RO92-01019A RO111680B1 (ro)	1991-07-24	1992-07-23	Complex de pleuromutilina, procedeu pentru prepararea acestuia si preparat farmaceutic
AT92112634T ATE157260T1 (de)	1991-07-24	1992-07-23	Pleuromotuline komplexe
CN92108688A CN1039319C (zh)	1991-07-24	1992-07-23	制备截短侧耳素衍生物与环糊精的配合物的方法
JP19666592A JP3296847B2 (ja)	1991-07-24	1992-07-23	プルロムチリン複合体
CS922311A CZ281620B6 (cs)	1991-07-24	1992-07-23	Komplex pleuromutilinového derivátu a cyklodextrinu, způsob jeho přípravy a farmaceutická kompozice tento komplex obsahující
ZA925600A ZA925600B (en)	1991-07-24	1992-07-24	Pleuromutilin complexes
TW081105891A TW307770B (de)	1991-07-24	1992-07-25
SA92130137A SA92130137B1 (ar)	1991-07-24	1992-09-30	معقدات مشتق للبلوروميوتيلين
US08/402,272 US5578585A (en)	1991-07-24	1995-03-10	Pleuromutilin derivative complexes
HU95P/P00678P HU211650A9 (en)	1991-07-24	1995-06-30	Pleuromutilin complexes
GR970403146T GR3025497T3 (en)	1991-07-24	1997-11-26	Pleuromutilin complexes

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0147791A AT400674B (de)	1991-07-24	1991-07-24	Pharmazeutische pleuromutilin-zubereitung

Publications (2)

Publication Number	Publication Date
ATA147791A true ATA147791A (de)	1995-07-15
AT400674B AT400674B (de)	1996-02-26

Family

ID=3514745

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0147791A AT400674B (de)	1991-07-24	1991-07-24	Pharmazeutische pleuromutilin-zubereitung
AT92112634T ATE157260T1 (de)	1991-07-24	1992-07-23	Pleuromotuline komplexe

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT92112634T ATE157260T1 (de)	1991-07-24	1992-07-23	Pleuromotuline komplexe

Country Status (29)

Country	Link
US (1)	US5578585A (de)
EP (1)	EP0524632B1 (de)
JP (1)	JP3296847B2 (de)
KR (1)	KR100237719B1 (de)
CN (1)	CN1039319C (de)
AT (2)	AT400674B (de)
AU (1)	AU656987B2 (de)
BG (1)	BG61864B1 (de)
BR (1)	BR9202804A (de)
CA (1)	CA2074385C (de)
CZ (1)	CZ281620B6 (de)
DE (1)	DE69221793T2 (de)
DK (1)	DK0524632T3 (de)
ES (1)	ES2104775T3 (de)
FI (1)	FI104788B (de)
GR (1)	GR3025497T3 (de)
HU (2)	HU214589B (de)
IE (1)	IE80625B1 (de)
IL (1)	IL102597A (de)
MX (1)	MX9204318A (de)
NO (1)	NO300445B1 (de)
NZ (1)	NZ243662A (de)
RO (1)	RO111680B1 (de)
RU (1)	RU2099324C1 (de)
SA (1)	SA92130137B1 (de)
SG (1)	SG44633A1 (de)
SK (1)	SK280773B6 (de)
TW (1)	TW307770B (de)
ZA (1)	ZA925600B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9614017D0 (en) *	1996-07-04	1996-09-04	Biochemie Gmbh	Organic compounds
UY25225A1 (es)	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
TWI260220B (en) *	1999-11-22	2006-08-21	Novartis Ag	A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
US6716448B2 (en)	2001-10-05	2004-04-06	Rubicon Scientific Llc	Domesticated household pet food including maintenance amounts of ivermectin
US7052712B2 (en) *	2001-10-05	2006-05-30	Rubicon Scientific Llc	Animal feeds including actives and methods of preparing same
US6866862B2 (en) *	2001-10-05	2005-03-15	Rubicon Scientific	Animal feeds including heartworm-prevention drugs
CO5390081A1 (es) *	2001-11-28	2004-04-30	Novartis Ag	Compuestos organicos
GB0207495D0 (en) *	2002-03-28	2002-05-08	Biochemie Gmbh	Organic compounds
GB0218578D0 (en) *	2002-08-09	2002-09-18	Glaxo Group Ltd	Novel method
KR20040027191A (ko) *	2002-09-27	2004-04-01	대한민국 (강원대학교)	콜레스테롤이 감소된 알(卵)의 생산방법
GB0308114D0 (en) *	2003-04-08	2003-05-14	Glaxo Group Ltd	Novel compounds
PL1729813T3 (pl)	2004-04-01	2011-09-30	Pf Medicament	Kompleksy inkluzyjne zawierające piroksykam, cyklodekstrynę i argininę
EP1686115A1 (de) *	2005-01-26	2006-08-02	Novartis AG	Organische Säureadditionssalze von Valnemulin
CN101313011B (zh) *	2005-09-22	2011-03-30	东丽株式会社	聚芳撑硫醚及其制备方法
EP2159220A1 (de) *	2008-09-02	2010-03-03	Nabriva Therapeutics AG	Organische Verbindungen
CN102266319B (zh) *	2011-07-25	2012-11-28	武汉回盛生物科技有限公司	一种兽用盐酸沃尼妙林预混剂及其制备方法
CN102764252A (zh) *	2012-08-07	2012-11-07	湖北龙翔药业有限公司	一种盐酸沃尼妙林的用途
US10532102B2 (en)	2016-08-19	2020-01-14	Foresee Pharmaceuticals Co., Ltd.	Pharmaceutical composition and methods of uses

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4092424A (en) *	1964-04-17	1978-05-30	Biochemie Ges.M.B.H.	Antibiotic derivatives
US4041175A (en) *	1974-05-13	1977-08-09	E. R. Squibb & Sons, Inc.	Use of pleuromutilin for the treatment of swine dysentery
US3987194A (en) *	1975-05-12	1976-10-19	E. R. Squibb & Sons, Inc.	Use of pleuromutilin derivatives for the treatment of swine dysentery
US4086359A (en) *	1975-09-30	1978-04-25	E. R. Squibb & Sons, Inc.	Derivatives of pleuromutilin and compositions
CH627940A5 (de) *	1976-12-23	1982-02-15	Sandoz Ag	Kokzidiostatisches kombinationspraeparat.
US4130709A (en) *	1977-12-08	1978-12-19	Eli Lilly And Company	Pleuromutilin glycoside derivatives
US4129721A (en) *	1977-12-08	1978-12-12	Eli Lilly And Company	A-40104 antibiotics and process for production thereof
DE2966635D1 (en) *	1979-01-12	1984-03-08	Sandoz Ag	New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
GB2072012B (en) *	1980-03-14	1984-07-25	Squibb & Sons Inc	Veterinary compositions containing pleuromutilin derivatives
JPS58148816A (ja) *	1982-02-27	1983-09-05	Nippon Zenyaku Kogyo Kk	低刺激性チアムリン注射剤
JPS58177949A (ja) *	1982-04-12	1983-10-18	Takeda Chem Ind Ltd	ランカシジン群抗生物質包接化合物
JPS5910510A (ja) *	1982-07-08	1984-01-20	Nippon Zenyaku Kogyo Kk	低刺激性チアムリン注射剤
DE3560511D1 (en) *	1984-02-17	1987-10-01	Sandoz Ag	Pleuromutilin derivatives, process for their preparation and their use
JPS6191125A (ja) *	1984-10-11	1986-05-09	Nippon Zeon Co Ltd	Ｓ−アデノシル−ｌ−メチオニン含有組成物及びその製造法
JPS62120344A (ja) *	1985-11-20	1987-06-01	Nippon Redarii Kk	４−ビフエニリル酢酸エステル−シクロデキストリン包接化合物
JPS62123196A (ja) *	1985-11-22	1987-06-04	Nisshin Flour Milling Co Ltd	プレドニゾロン包接化合物
GB8613688D0 (en) *	1986-06-05	1986-07-09	Euro Celtique Sa	Pharmaceutical composition
JPS63139130A (ja) *	1986-11-29	1988-06-10	Nippon Funmatsu Yakuhin Kk	長期安定型の漢方薬軟エキスの製造法
JPH0819004B2 (ja) *	1986-12-26	1996-02-28	日清製粉株式会社	徐放性医薬製剤
JPS6463552A (en) *	1987-09-04	1989-03-09	Lederle Japan Ltd	4-biphenylylacetic acid ester-cyclodextrin inclusion compound
CA1321192C (en) *	1988-04-20	1993-08-10	Abdul Majid	Inclusion complexes of cyclodextrins by agglomeration
US5007966A (en) *	1988-09-21	1991-04-16	American Maize-Products Company	Cyclodextrin complexing method

1991
- 1991-07-24 AT AT0147791A patent/AT400674B/de not_active IP Right Cessation
1992
- 1992-07-13 HU HU9202307A patent/HU214589B/hu not_active IP Right Cessation
- 1992-07-22 CA CA002074385A patent/CA2074385C/en not_active Expired - Fee Related
- 1992-07-22 NZ NZ243662A patent/NZ243662A/en unknown
- 1992-07-22 NO NO922901A patent/NO300445B1/no not_active IP Right Cessation
- 1992-07-22 IL IL10259792A patent/IL102597A/en not_active IP Right Cessation
- 1992-07-22 BR BR929202804A patent/BR9202804A/pt not_active Application Discontinuation
- 1992-07-22 BG BG96678A patent/BG61864B1/bg unknown
- 1992-07-22 FI FI923342A patent/FI104788B/fi active
- 1992-07-22 AU AU20536/92A patent/AU656987B2/en not_active Ceased
- 1992-07-23 CZ CS922311A patent/CZ281620B6/cs not_active IP Right Cessation
- 1992-07-23 SK SK2311-92A patent/SK280773B6/sk not_active IP Right Cessation
- 1992-07-23 RO RO92-01019A patent/RO111680B1/ro unknown
- 1992-07-23 EP EP92112634A patent/EP0524632B1/de not_active Expired - Lifetime
- 1992-07-23 KR KR1019920013120A patent/KR100237719B1/ko not_active Expired - Fee Related
- 1992-07-23 ES ES92112634T patent/ES2104775T3/es not_active Expired - Lifetime
- 1992-07-23 DE DE69221793T patent/DE69221793T2/de not_active Expired - Fee Related
- 1992-07-23 JP JP19666592A patent/JP3296847B2/ja not_active Expired - Fee Related
- 1992-07-23 AT AT92112634T patent/ATE157260T1/de not_active IP Right Cessation
- 1992-07-23 SG SG1996004628A patent/SG44633A1/en unknown
- 1992-07-23 CN CN92108688A patent/CN1039319C/zh not_active Expired - Fee Related
- 1992-07-23 DK DK92112634.8T patent/DK0524632T3/da not_active Application Discontinuation
- 1992-07-23 IE IE922392A patent/IE80625B1/en not_active IP Right Cessation
- 1992-07-23 RU SU925052221A patent/RU2099324C1/ru active
- 1992-07-23 MX MX9204318A patent/MX9204318A/es unknown
- 1992-07-24 ZA ZA925600A patent/ZA925600B/xx unknown
- 1992-07-25 TW TW081105891A patent/TW307770B/zh active
- 1992-09-30 SA SA92130137A patent/SA92130137B1/ar unknown
1995
- 1995-03-10 US US08/402,272 patent/US5578585A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00678P patent/HU211650A9/hu unknown
1997
- 1997-11-26 GR GR970403146T patent/GR3025497T3/el unknown

Also Published As

Publication number	Publication date
HU9202307D0 (en)	1992-10-28
FI923342A0 (fi)	1992-07-22
GR3025497T3 (en)	1998-02-27
JP3296847B2 (ja)	2002-07-02
IL102597A0 (en)	1993-01-14
NO922901L (no)	1993-01-25
SK280773B6 (sk)	2000-07-11
SA92130137B1 (ar)	2005-06-08
HUT63828A (en)	1993-10-28
TW307770B (de)	1997-06-11
KR930002378A (ko)	1993-02-23
HU214589B (hu)	1998-04-28
CN1068813A (zh)	1993-02-10
FI923342L (fi)	1993-01-25
BG96678A (bg)	1994-03-24
AU2053692A (en)	1993-01-28
AT400674B (de)	1996-02-26
DK0524632T3 (da)	1997-09-29
BR9202804A (pt)	1994-01-25
CZ231192A3 (en)	1993-02-17
NO922901D0 (no)	1992-07-22
CA2074385C (en)	2003-09-23
FI104788B (fi)	2000-04-14
US5578585A (en)	1996-11-26
SK231192A3 (en)	1995-03-08
CA2074385A1 (en)	1993-01-25
NO300445B1 (no)	1997-06-02
IE922392A1 (en)	1993-01-27
RU2099324C1 (ru)	1997-12-20
RO111680B1 (ro)	1996-12-30
JPH05201962A (ja)	1993-08-10
ZA925600B (en)	1994-01-24
AU656987B2 (en)	1995-02-23
ATE157260T1 (de)	1997-09-15
HU211650A9 (en)	1995-12-28
BG61864B1 (bg)	1998-08-31
KR100237719B1 (ko)	2000-01-15
CN1039319C (zh)	1998-07-29
EP0524632A1 (de)	1993-01-27
IE80625B1 (en)	1998-10-21
MX9204318A (es)	1994-07-29
NZ243662A (en)	1994-10-26
DE69221793D1 (de)	1997-10-02
DE69221793T2 (de)	1998-03-12
EP0524632B1 (de)	1997-08-27
SG44633A1 (en)	1997-12-19
CZ281620B6 (cs)	1996-11-13
ES2104775T3 (es)	1997-10-16
IL102597A (en)	1996-06-18

Legal Events

Date	Code	Title	Description
1997-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATA147791A (de)	1995-07-15	Pharmazeutische pleuromutilin-zubereitung
DE69223914D1 (de)	1998-02-12	4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate
IL80437A0 (en)	1987-01-30	Benzimidazole derivatives and pharmaceutical compositions containing them
ATE87319T1 (de)	1993-04-15	Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate.
FI940072A0 (fi)	1994-01-07	Pyrrolidiinijohdannaiset, niiden valmistus ja niitä sisältävät lääkkeet
DE59009074D1 (de)	1995-06-22	Diarylsubstituierte heterocyclische Verbindung, ihre Herstellung und Arzneimittel und Kosmetika daraus.
ATE146186T1 (de)	1996-12-15	Trifluormethylketon peptid derivate mit hle- inhibierende aktivität, deren herstellung und pharmazeutischen zusammensetzungen
NO307326B1 (no)	2000-03-20	Lipofile, oligosakkaride antibiotikasaltpreparater
IL108071A0 (en)	1994-04-12	Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines their preparation and pharmaceutical compositions containing them
NO301542B1 (no)	1997-11-10	Nye pyrazin-derivater
DE69222698D1 (de)	1997-11-20	4-desoxy-4-epipodophyllotoxinderivate oder deren pharmazeutisch akzeptierbaren salze
SE8600658D0 (sv)	1986-02-14	Novel composition of matter
ITMI911853A1 (it)	1993-01-04	Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono.
IL102949A0 (en)	1993-01-31	Substituted mandelic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA846425B (en)	1985-03-27	Benzoic acid derivatives process for preparation and application as drugs,disinfectants or preservatives
DE69132578D1 (de)	2001-05-10	Cephemderivate
ATE14437T1 (de)	1985-08-15	Aminoglycosid-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und solche derivate zur verwendung als arzneimittel.