ATA186795A - Verfahren zur fällung von alkalisalzen der clavulansäure - Google Patents

Verfahren zur fällung von alkalisalzen der clavulansäure

Info

Publication number
ATA186795A
ATA186795A AT0186795A AT186795A ATA186795A AT A186795 A ATA186795 A AT A186795A AT 0186795 A AT0186795 A AT 0186795A AT 186795 A AT186795 A AT 186795A AT A186795 A ATA186795 A AT A186795A
Authority
AT
Austria
Prior art keywords
clavulanic acid
pct
butanol
alkaline salts
date
Prior art date
Application number
AT0186795A
Other languages
English (en)
Other versions
AT403375B (de
Inventor
Helmut Dr Wagner
Harald Dr Summer
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0186795A priority Critical patent/AT403375B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to US09/068,241 priority patent/US6133441A/en
Priority to KR1019980703498A priority patent/KR100537732B1/ko
Priority to DE69631608T priority patent/DE69631608T2/de
Priority to ES96939048T priority patent/ES2216073T3/es
Priority to AU76250/96A priority patent/AU714017B2/en
Priority to HK99101818.0A priority patent/HK1016971B/en
Priority to IL12435396A priority patent/IL124353A/xx
Priority to SK640-98A priority patent/SK285138B6/sk
Priority to CZ0149198A priority patent/CZ296567B6/cs
Priority to BR9611572A priority patent/BR9611572A/pt
Priority to PCT/EP1996/005015 priority patent/WO1997018216A1/en
Priority to PL96326696A priority patent/PL188634B1/pl
Priority to RU98111764/04A priority patent/RU2179171C2/ru
Priority to JP51859197A priority patent/JP4319252B2/ja
Priority to CN96199075A priority patent/CN1090636C/zh
Priority to TR1998/00860T priority patent/TR199800860T2/xx
Priority to CA002237763A priority patent/CA2237763C/en
Priority to HU9903478A priority patent/HUP9903478A3/hu
Priority to NZ322485A priority patent/NZ322485A/xx
Priority to TW085113953A priority patent/TW427991B/zh
Priority to SI9630672T priority patent/SI0874855T1/xx
Priority to AT96939048T priority patent/ATE259817T1/de
Priority to EP96939048A priority patent/EP0874855B1/de
Publication of ATA186795A publication Critical patent/ATA186795A/de
Application granted granted Critical
Publication of AT403375B publication Critical patent/AT403375B/de
Priority to NO982107A priority patent/NO982107D0/no
Priority to MX9803887A priority patent/MX9803887A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D503/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT0186795A 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure AT403375B (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure
RU98111764/04A RU2179171C2 (ru) 1995-11-15 1996-11-14 Способ получения соли клавулановой кислоты
DE69631608T DE69631608T2 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz
ES96939048T ES2216073T3 (es) 1995-11-15 1996-11-14 Producto de una sal de acido clavulanico.
CN96199075A CN1090636C (zh) 1995-11-15 1996-11-14 棒酸盐的制备
HK99101818.0A HK1016971B (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
IL12435396A IL124353A (en) 1995-11-15 1996-11-14 Production of a potassium salt of clavulanic acid
SK640-98A SK285138B6 (sk) 1995-11-15 1996-11-14 Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny
CZ0149198A CZ296567B6 (cs) 1995-11-15 1996-11-14 Zpusob prípravy draselné soli kyseliny klavulanové
BR9611572A BR9611572A (pt) 1995-11-15 1996-11-14 Produção de um sal de ácido clavulânico
PCT/EP1996/005015 WO1997018216A1 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
PL96326696A PL188634B1 (pl) 1995-11-15 1996-11-14 Sposób wytwarzania potasowej soli kwasu klawulanowego
US09/068,241 US6133441A (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
JP51859197A JP4319252B2 (ja) 1995-11-15 1996-11-14 クラブラン酸の塩の製造
AU76250/96A AU714017B2 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
TR1998/00860T TR199800860T2 (xx) 1995-11-15 1996-11-14 Bir klavulanik asit tuzu �retimi.
CA002237763A CA2237763C (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
HU9903478A HUP9903478A3 (en) 1995-11-15 1996-11-14 New process for the production of a salt of clavulanic acid
NZ322485A NZ322485A (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid using n-butanol or isobutanol as the solvent which contains 0.5-10% of water
TW085113953A TW427991B (en) 1995-11-15 1996-11-14 Production of pharmaceutically acceptable salts of clavulanic acid
SI9630672T SI0874855T1 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid
AT96939048T ATE259817T1 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz
EP96939048A EP0874855B1 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz
KR1019980703498A KR100537732B1 (ko) 1995-11-15 1996-11-14 클라불란산염의제조
NO982107A NO982107D0 (no) 1995-11-15 1998-05-08 Fremstilling av et salt av klavulansyre
MX9803887A MX9803887A (es) 1995-11-15 1998-05-15 Produccion de una sal de acido clavulanico.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure

Publications (2)

Publication Number Publication Date
ATA186795A true ATA186795A (de) 1997-06-15
AT403375B AT403375B (de) 1998-01-26

Family

ID=3522721

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure
AT96939048T ATE259817T1 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT96939048T ATE259817T1 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz

Country Status (24)

Country Link
US (1) US6133441A (de)
EP (1) EP0874855B1 (de)
JP (1) JP4319252B2 (de)
KR (1) KR100537732B1 (de)
CN (1) CN1090636C (de)
AT (2) AT403375B (de)
AU (1) AU714017B2 (de)
BR (1) BR9611572A (de)
CA (1) CA2237763C (de)
CZ (1) CZ296567B6 (de)
DE (1) DE69631608T2 (de)
ES (1) ES2216073T3 (de)
HU (1) HUP9903478A3 (de)
IL (1) IL124353A (de)
MX (1) MX9803887A (de)
NO (1) NO982107D0 (de)
NZ (1) NZ322485A (de)
PL (1) PL188634B1 (de)
RU (1) RU2179171C2 (de)
SI (1) SI0874855T1 (de)
SK (1) SK285138B6 (de)
TR (1) TR199800860T2 (de)
TW (1) TW427991B (de)
WO (1) WO1997018216A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
MXPA03003312A (es) * 2000-10-20 2004-12-03 Biochemie Gmbh Composiciones farmaceuticas.
CA2702257C (en) * 2007-10-09 2016-07-12 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
US9975905B2 (en) 2013-03-12 2018-05-22 Gladius Pharmaceuticals Corporation Derivatized 3-styryl-cephalosporins
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8618888D0 (en) * 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) * 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2008418A6 (es) * 1987-01-29 1989-07-16 Beecham Group Plc Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) * 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
DE69618045D1 (de) * 1995-02-25 2002-01-31 Spurcourt Ltd Clavulansäure Salz
GB2298201B (en) * 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
SI0874855T1 (en) 2004-06-30
TR199800860T2 (xx) 2000-07-21
CN1090636C (zh) 2002-09-11
CZ149198A3 (cs) 1998-08-12
CA2237763A1 (en) 1997-05-22
NO982107L (no) 1998-05-08
DE69631608D1 (de) 2004-03-25
SK285138B6 (sk) 2006-07-07
KR100537732B1 (ko) 2006-04-14
IL124353A0 (en) 1998-12-06
ATE259817T1 (de) 2004-03-15
PL188634B1 (pl) 2005-03-31
HUP9903478A3 (en) 2000-05-29
KR19990067480A (ko) 1999-08-25
RU2179171C2 (ru) 2002-02-10
HK1016971A1 (en) 1999-11-12
EP0874855A1 (de) 1998-11-04
IL124353A (en) 2005-06-19
AU714017B2 (en) 1999-12-16
EP0874855B1 (de) 2004-02-18
CN1204337A (zh) 1999-01-06
PL326696A1 (en) 1998-10-26
BR9611572A (pt) 1999-03-30
MX9803887A (es) 1998-09-30
NZ322485A (en) 2000-01-28
DE69631608T2 (de) 2004-12-23
AT403375B (de) 1998-01-26
JP4319252B2 (ja) 2009-08-26
ES2216073T3 (es) 2004-10-16
US6133441A (en) 2000-10-17
AU7625096A (en) 1997-06-05
JP2000500149A (ja) 2000-01-11
CA2237763C (en) 2008-05-06
CZ296567B6 (cs) 2006-04-12
WO1997018216A1 (en) 1997-05-22
HUP9903478A2 (hu) 2000-03-28
SK64098A3 (en) 1998-10-07
TW427991B (en) 2001-04-01
NO982107D0 (no) 1998-05-08

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