ATA234689A - Neue 2-carbonyl substituierte n,n'-di(trimethoxybenzoyl)piperazine, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen - Google Patents

Neue 2-carbonyl substituierte n,n'-di(trimethoxybenzoyl)piperazine, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen

Info

Publication number: ATA234689A
Authority: AT; Austria
Prior art keywords: trimethoxybenzoyl; piperazine; new; production; compositions containing
Prior art date: 1988-10-11

Application number

AT0234689A

Other languages

English (en)

Other versions

AT395423B (de

Inventor

Eduardo Pirotsky

Georges Dive

Jean-Jacques Godfroid

Francoise Heymans

Pierre Braquet

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-11

Filing date

1989-10-11

Publication date

1992-05-15

1989-10-11 Application filed by Scras filed Critical Scras

1992-05-15 Publication of ATA234689A publication Critical patent/ATA234689A/de

1992-12-28 Application granted granted Critical

1992-12-28 Publication of AT395423B publication Critical patent/AT395423B/de

Links

BXGYJDKDOLUZTG-UHFFFAOYSA-N [4-(2,3,4-trimethoxybenzoyl)piperazin-1-yl]-(2,3,4-trimethoxyphenyl)methanone Chemical class COC1=C(OC)C(OC)=CC=C1C(=O)N1CCN(C(=O)C=2C(=C(OC)C(OC)=CC=2)OC)CC1 BXGYJDKDOLUZTG-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT0234689A 1988-10-11 1989-10-11 Neue 2-carbonyl substituierte n,n'-di(trimethoxybenzoyl)piperazine, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen AT395423B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888823775A GB8823775D0 (en)	1988-10-11	1988-10-11	New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines

Publications (2)

Publication Number	Publication Date
ATA234689A true ATA234689A (de)	1992-05-15
AT395423B AT395423B (de)	1992-12-28

Family

ID=10644988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0234689A AT395423B (de)	1988-10-11	1989-10-11	Neue 2-carbonyl substituierte n,n'-di(trimethoxybenzoyl)piperazine, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen

Country Status (33)

Country	Link
US (1)	US4923870A (de)
JP (1)	JPH0635452B2 (de)
KR (1)	KR970004912B1 (de)
AR (1)	AR245110A1 (de)
AT (1)	AT395423B (de)
AU (1)	AU618220B2 (de)
BE (1)	BE1003519A3 (de)
CA (1)	CA1320958C (de)
CH (1)	CH679859A5 (de)
DE (1)	DE3933881C2 (de)
DK (1)	DK500389A (de)
DZ (1)	DZ1365A1 (de)
ES (1)	ES2018403A6 (de)
FI (1)	FI96854C (de)
FR (2)	FR2637500B1 (de)
GB (2)	GB8823775D0 (de)
GR (1)	GR1000343B (de)
HK (1)	HK47592A (de)
IE (1)	IE62011B1 (de)
IN (1)	IN173325B (de)
IT (1)	IT1237088B (de)
LU (1)	LU87604A1 (de)
MA (1)	MA21652A1 (de)
MY (1)	MY106235A (de)
NL (1)	NL8902520A (de)
NO (1)	NO176180C (de)
NZ (1)	NZ230927A (de)
OA (1)	OA09139A (de)
PT (1)	PT91941B (de)
SE (1)	SE505239C2 (de)
SG (1)	SG41292G (de)
TN (1)	TNSN89110A1 (de)
ZA (1)	ZA897554B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8823776D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8908587D0 (en) *	1989-04-15	1989-06-01	Scras Societe De Conseils De R	New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
WO1992020661A1 (en) *	1991-05-22	1992-11-26	Merck & Co., Inc.	N, n-diacylpiperazines
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) *	1993-06-22	1994-09-20	Merck & Co., Inc.	N,N-diacylpiperazines
FR2780649B1 (fr)	1998-07-06	2001-03-09	Univ Paris Vii Denis Diderot	Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3186993A (en) *	1962-06-07	1965-06-01	Ethyl Corp	alpha, alpha'-(1, 4-piperazinediyl) bis (3, 5-dialkyl-4-hydroxythiobenzaldehyde) compounds
GB1243991A (en) *	1968-06-10	1971-08-25	Ici Ltd	Piperidine, morpholine and piperazine derivatives
FR2209560A1 (en) *	1972-12-07	1974-07-05	Degussa	N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
DE2423847A1 (de) *	1973-05-28	1975-01-02	Ciba Geigy Ag	Neue sulfamoylbenzoesaeureamide
GB8427735D0 (en) *	1984-11-02	1984-12-12	Fujisawa Pharmaceutical Co	Piperazine compound
FR2581993B1 (fr) *	1985-05-14	1988-03-18	Synthelabo	Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
DE3636278A1 (de) *	1986-10-24	1988-05-05	Hoechst Ag	Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
IL85700A0 (en) *	1987-03-24	1988-08-31	Takeda Chemical Industries Ltd	1,4-disubstituted piperazine compounds,their production and use
GB8823776D0 (en) *	1988-10-11	1988-11-16	Scras	New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) *	1988-11-11	1991-03-05	Takeda Chemical Industries, Ltd.	Trisubstituted piperazine compounds, their production and use

1988
- 1988-10-11 GB GB888823775A patent/GB8823775D0/en active Pending
1989
- 1989-09-29 CA CA000615178A patent/CA1320958C/en not_active Expired - Fee Related
- 1989-10-03 IN IN875DE1989 patent/IN173325B/en unknown
- 1989-10-04 ZA ZA897554A patent/ZA897554B/xx unknown
- 1989-10-06 CH CH3658/89A patent/CH679859A5/fr not_active IP Right Cessation
- 1989-10-06 NZ NZ230927A patent/NZ230927A/xx unknown
- 1989-10-06 US US07/418,114 patent/US4923870A/en not_active Expired - Lifetime
- 1989-10-09 GR GR890100647A patent/GR1000343B/el not_active IP Right Cessation
- 1989-10-09 DZ DZ890157A patent/DZ1365A1/fr active
- 1989-10-09 SE SE8903312A patent/SE505239C2/sv not_active IP Right Cessation
- 1989-10-10 AU AU42688/89A patent/AU618220B2/en not_active Ceased
- 1989-10-10 DK DK500389A patent/DK500389A/da not_active Application Discontinuation
- 1989-10-10 MA MA21904A patent/MA21652A1/fr unknown
- 1989-10-10 KR KR1019890014506A patent/KR970004912B1/ko not_active Expired - Fee Related
- 1989-10-10 NO NO894038A patent/NO176180C/no not_active IP Right Cessation
- 1989-10-10 PT PT91941A patent/PT91941B/pt not_active IP Right Cessation
- 1989-10-10 ES ES8903410A patent/ES2018403A6/es not_active Expired - Lifetime
- 1989-10-10 MY MYPI89001392A patent/MY106235A/en unknown
- 1989-10-10 TN TNTNSN89110A patent/TNSN89110A1/fr unknown
- 1989-10-10 IE IE325889A patent/IE62011B1/en not_active IP Right Cessation
- 1989-10-10 LU LU87604A patent/LU87604A1/fr unknown
- 1989-10-10 BE BE8901089A patent/BE1003519A3/fr not_active IP Right Cessation
- 1989-10-10 AR AR89315126A patent/AR245110A1/es active
- 1989-10-11 FI FI894812A patent/FI96854C/fi not_active IP Right Cessation
- 1989-10-11 GB GB8922870A patent/GB2223753B/en not_active Expired - Lifetime
- 1989-10-11 IT IT02199289A patent/IT1237088B/it active IP Right Grant
- 1989-10-11 AT AT0234689A patent/AT395423B/de not_active IP Right Cessation
- 1989-10-11 FR FR898913261A patent/FR2637500B1/fr not_active Expired - Lifetime
- 1989-10-11 JP JP1263142A patent/JPH0635452B2/ja not_active Expired - Lifetime
- 1989-10-11 DE DE3933881A patent/DE3933881C2/de not_active Expired - Fee Related
- 1989-10-11 NL NL8902520A patent/NL8902520A/nl not_active Application Discontinuation
- 1989-10-11 FR FR898913260A patent/FR2637593B1/fr not_active Expired - Lifetime
- 1989-10-11 OA OA59663A patent/OA09139A/xx unknown
1992
- 1992-04-14 SG SG412/92A patent/SG41292G/en unknown
- 1992-07-02 HK HK475/92A patent/HK47592A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
SG41292G (en)	1992-06-12
FI894812L (fi)	1990-04-12
HK47592A (en)	1992-07-10
DE3933881C2 (de)	1994-06-30
FI96854C (fi)	1996-09-10
PT91941B (pt)	1995-05-31
GB8922870D0 (en)	1989-11-29
FI96854B (fi)	1996-05-31
JPH02223565A (ja)	1990-09-05
IN173325B (de)	1994-04-02
MA21652A1 (fr)	1990-07-01
IT8921992A1 (it)	1991-04-11
CH679859A5 (de)	1992-04-30
TNSN89110A1 (fr)	1991-02-04
FR2637593B1 (fr)	1992-06-05
IE893258L (en)	1990-04-11
SE8903312D0 (sv)	1989-10-09
LU87604A1 (fr)	1990-02-07
AU4268889A (en)	1990-04-26
KR970004912B1 (ko)	1997-04-08
NZ230927A (en)	1991-01-29
GB8823775D0 (en)	1988-11-16
AR245110A1 (es)	1993-12-30
NO894038D0 (no)	1989-10-10
GB2223753A (en)	1990-04-18
IT8921992A0 (it)	1989-10-11
AU618220B2 (en)	1991-12-12
DZ1365A1 (fr)	2004-09-13
SE8903312L (sv)	1990-04-12
NL8902520A (nl)	1990-05-01
IE62011B1 (en)	1994-12-14
AT395423B (de)	1992-12-28
BE1003519A3 (fr)	1992-04-14
FR2637593A1 (fr)	1990-04-13
GR1000343B (el)	1992-06-25
FR2637500A1 (fr)	1990-04-13
DE3933881A1 (de)	1990-04-12
US4923870A (en)	1990-05-08
FI894812A0 (fi)	1989-10-11
NO894038L (no)	1990-04-17
MY106235A (en)	1995-04-29
NO176180C (no)	1995-02-15
ES2018403A6 (es)	1991-04-01
FR2637500B1 (fr)	1992-06-05
CA1320958C (en)	1993-08-03
NO176180B (no)	1994-11-07
DK500389D0 (da)	1989-10-10
PT91941A (pt)	1990-04-30
GR890100647A (en)	1990-11-29
DK500389A (da)	1990-04-12
ZA897554B (en)	1990-07-25
SE505239C2 (sv)	1997-07-21
IT1237088B (it)	1993-05-18
OA09139A (fr)	1991-10-31
GB2223753B (en)	1992-01-02
JPH0635452B2 (ja)	1994-05-11
KR900006309A (ko)	1990-05-07

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Legal Events

Date	Code	Title	Description
2005-01-15	ELJ	Ceased due to non-payment of the annual fee