ATA266589A - Verfahren zur herstellung der 2-(2-(4-((4-chlor- phenyl)-phenylmethyl)-1-piperazinyl)ethoxy)- essigsäure und ihres dichlorhydrats - Google Patents
Verfahren zur herstellung der 2-(2-(4-((4-chlor- phenyl)-phenylmethyl)-1-piperazinyl)ethoxy)- essigsäure und ihres dichlorhydratsInfo
- Publication number
- ATA266589A ATA266589A AT0266589A AT266589A ATA266589A AT A266589 A ATA266589 A AT A266589A AT 0266589 A AT0266589 A AT 0266589A AT 266589 A AT266589 A AT 266589A AT A266589 A ATA266589 A AT A266589A
- Authority
- AT
- Austria
- Prior art keywords
- dichlorhydrate
- chlor
- phenylmethyl
- piperazinyl
- ethoxy
- Prior art date
Links
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888827391A GB8827391D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA266589A true ATA266589A (de) | 1994-07-15 |
| AT398971B AT398971B (de) | 1995-02-27 |
Family
ID=10647347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0266589A AT398971B (de) | 1988-11-23 | 1989-11-22 | Verfahren zur herstellung der 2-(2-(4-((4-chlor- phenyl)-phenylmethyl)-1-piperazinyl)ethoxy)- essigsäure und ihres dichlorhydrats |
Country Status (16)
| Country | Link |
|---|---|
| KR (1) | KR970009728B1 (de) |
| AT (1) | AT398971B (de) |
| CA (1) | CA1317300C (de) |
| CY (1) | CY1671A (de) |
| DK (1) | DK174543B1 (de) |
| ES (1) | ES2021907A6 (de) |
| FI (1) | FI91862C (de) |
| GB (2) | GB8827391D0 (de) |
| GR (1) | GR1000553B (de) |
| HK (1) | HK95892A (de) |
| HU (1) | HU205094B (de) |
| NO (1) | NO172342C (de) |
| PH (1) | PH25982A (de) |
| PL (1) | PL161379B1 (de) |
| PT (1) | PT92364B (de) |
| SG (1) | SG89492G (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU703690B2 (en) * | 1992-09-24 | 1999-04-01 | Sepracor, Inc. | Methods for treating allergic disorders using optically pure (+)cetirizine |
| AU5136193A (en) * | 1992-09-24 | 1994-04-12 | Sepracor, Inc. | Methods and compositions for treating allergic disorders using optically pure (+) cetirizine |
| CA2145410A1 (en) * | 1992-09-24 | 1994-03-31 | Nancy M. Gray | Compositions for treating allergic disorders using (-) cetirizine |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| US6469009B1 (en) | 1996-04-08 | 2002-10-22 | Ucb, S.A. | Pharmaceutical compositions for the treatment of rhinitis |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| BE1010094A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
| AU7455798A (en) | 1997-06-04 | 1998-12-21 | Nippon Shoji Kaisha, Ltd. | Process for producing piperazinesulfonamide derivatives and salts thereof |
| EP0919550A1 (de) * | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Pseudopolymorphische Formen der 2-2-4-Bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxyessigsäure Dihydrochloride |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| GR990100135A (el) * | 1999-04-22 | 2000-12-29 | Genepharm �.�. | Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου |
| JP2002249487A (ja) * | 2001-02-22 | 2002-09-06 | Sumitomo Chem Co Ltd | ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。 |
| US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| CA2514145A1 (en) * | 2003-01-23 | 2004-08-05 | Ucb Farchim Sa | Piperazine derivatives and their use as synthesis intermediates |
| KR100503443B1 (ko) | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
| NZ556580A (en) * | 2005-03-03 | 2009-08-28 | Ucb Farchim Sa | Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine |
| HU227325B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| SI22489A (sl) * | 2007-03-12 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za pripravo levocetirizina in njegovih intermediatov |
| EP2121643B1 (de) | 2007-03-12 | 2013-10-23 | Krka, tovarna zdravil, d.d., Novo mesto | Neues verfahren zur herstellung von levocetirizin und zwischenprodukte davon |
| US8084606B2 (en) | 2007-06-15 | 2011-12-27 | Symed Labs Limited | Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates |
| WO2009062036A2 (en) * | 2007-11-09 | 2009-05-14 | Dr. Reddy's Laboratories Ltd. | Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof |
| PL2062881T3 (pl) | 2007-11-21 | 2011-07-29 | Synthon Bv | Sposób wytwarzania N-(difenylometylo)piperazyn |
| US7989623B2 (en) | 2007-11-21 | 2011-08-02 | Synthon Bv | Process for making n-(diphenylmethyl)piperazines |
| CN102046612A (zh) | 2008-06-02 | 2011-05-04 | 希普拉有限公司 | 合成左旋西替利嗪的方法和其中所用的中间体 |
| EP2297122B1 (de) * | 2008-06-11 | 2014-05-21 | KRKA, tovarna zdravil, d.d., Novo mesto | Neues verfahren zur herstellung von levocetirizin und zwischenprodukten davon |
| KR100998067B1 (ko) | 2008-09-08 | 2010-12-03 | 주식회사 삼오제약 | 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법 |
| US20110172425A1 (en) | 2008-09-17 | 2011-07-14 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| WO2010107404A1 (en) | 2009-03-16 | 2010-09-23 | Mahmut Bilgic | Stable pharmaceutical combinations |
| TR201007652A2 (tr) | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Sinerjik etki. |
| TR201009398A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Fiziksel özellikleri geliştirilmiş tablet formülasyonları |
| WO2012101475A1 (en) | 2011-01-27 | 2012-08-02 | Jubilant Life Sciences Limited | An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate |
| CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
| KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
| KR102226833B1 (ko) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
| CN104045607B (zh) * | 2014-05-21 | 2016-04-13 | 丽珠医药集团股份有限公司 | 一种盐酸西替利嗪的纯化方法 |
| CN105924409B (zh) * | 2016-05-12 | 2019-01-08 | 浙江永宁药业股份有限公司 | 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法 |
| CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI75816C (fi) * | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
-
1988
- 1988-11-23 GB GB888827391A patent/GB8827391D0/en active Pending
-
1989
- 1989-09-29 CA CA000614709A patent/CA1317300C/en not_active Expired - Fee Related
- 1989-11-20 GR GR890100770A patent/GR1000553B/el not_active IP Right Cessation
- 1989-11-21 GB GB8926243A patent/GB2225321B/en not_active Expired - Lifetime
- 1989-11-21 PT PT92364A patent/PT92364B/pt not_active IP Right Cessation
- 1989-11-22 ES ES8903975A patent/ES2021907A6/es not_active Expired - Lifetime
- 1989-11-22 PL PL1989282410A patent/PL161379B1/pl unknown
- 1989-11-22 FI FI895564A patent/FI91862C/fi not_active IP Right Cessation
- 1989-11-22 AT AT0266589A patent/AT398971B/de not_active IP Right Cessation
- 1989-11-22 HU HU896131A patent/HU205094B/hu not_active IP Right Cessation
- 1989-11-22 DK DK198905867A patent/DK174543B1/da not_active IP Right Cessation
- 1989-11-22 NO NO894651A patent/NO172342C/no not_active IP Right Cessation
- 1989-11-23 KR KR1019890017040A patent/KR970009728B1/ko not_active Expired - Fee Related
- 1989-11-23 PH PH39570A patent/PH25982A/en unknown
-
1992
- 1992-09-05 SG SG894/92A patent/SG89492G/en unknown
- 1992-12-03 HK HK958/92A patent/HK95892A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1671A patent/CY1671A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK174543B1 (da) | 2003-05-19 |
| HU896131D0 (en) | 1990-02-28 |
| GB2225321B (en) | 1992-04-08 |
| GB8926243D0 (en) | 1990-01-10 |
| DK586789A (da) | 1990-05-24 |
| PT92364B (pt) | 1995-07-18 |
| PL161379B1 (pl) | 1993-06-30 |
| FI895564A0 (fi) | 1989-11-22 |
| NO894651L (no) | 1990-05-25 |
| KR900007825A (ko) | 1990-06-02 |
| PT92364A (pt) | 1990-05-31 |
| HUT53627A (en) | 1990-11-28 |
| CA1317300C (en) | 1993-05-04 |
| HU205094B (en) | 1992-03-30 |
| GB8827391D0 (en) | 1988-12-29 |
| HK95892A (en) | 1992-12-11 |
| ES2021907A6 (es) | 1991-11-16 |
| CY1671A (en) | 1993-05-14 |
| FI91862C (fi) | 1994-08-25 |
| DK586789D0 (da) | 1989-11-22 |
| GR890100770A (en) | 1990-12-31 |
| KR970009728B1 (ko) | 1997-06-17 |
| SG89492G (en) | 1992-12-04 |
| FI91862B (fi) | 1994-05-13 |
| NO172342B (no) | 1993-03-29 |
| AT398971B (de) | 1995-02-27 |
| GB2225321A (en) | 1990-05-30 |
| GR1000553B (el) | 1992-08-26 |
| NO894651D0 (no) | 1989-11-22 |
| NO172342C (no) | 1993-07-07 |
| PH25982A (en) | 1992-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |