PT92364A - Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridrato - Google Patents
Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridratoInfo
- Publication number
- PT92364A PT92364A PT92364A PT9236489A PT92364A PT 92364 A PT92364 A PT 92364A PT 92364 A PT92364 A PT 92364A PT 9236489 A PT9236489 A PT 9236489A PT 92364 A PT92364 A PT 92364A
- Authority
- PT
- Portugal
- Prior art keywords
- acid
- chloridrethydro
- chloridrate
- etoxy
- phenylmethyl
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888827391A GB8827391D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT92364A true PT92364A (pt) | 1990-05-31 |
| PT92364B PT92364B (pt) | 1995-07-18 |
Family
ID=10647347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT92364A PT92364B (pt) | 1988-11-23 | 1989-11-21 | Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridrato |
Country Status (16)
| Country | Link |
|---|---|
| KR (1) | KR970009728B1 (pt) |
| AT (1) | AT398971B (pt) |
| CA (1) | CA1317300C (pt) |
| CY (1) | CY1671A (pt) |
| DK (1) | DK174543B1 (pt) |
| ES (1) | ES2021907A6 (pt) |
| FI (1) | FI91862C (pt) |
| GB (2) | GB8827391D0 (pt) |
| GR (1) | GR1000553B (pt) |
| HK (1) | HK95892A (pt) |
| HU (1) | HU205094B (pt) |
| NO (1) | NO172342C (pt) |
| PH (1) | PH25982A (pt) |
| PL (1) | PL161379B1 (pt) |
| PT (1) | PT92364B (pt) |
| SG (1) | SG89492G (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU703690B2 (en) * | 1992-09-24 | 1999-04-01 | Sepracor, Inc. | Methods for treating allergic disorders using optically pure (+)cetirizine |
| AU5136193A (en) * | 1992-09-24 | 1994-04-12 | Sepracor, Inc. | Methods and compositions for treating allergic disorders using optically pure (+) cetirizine |
| DE10199031I2 (de) * | 1992-09-24 | 2004-09-23 | Sepracor Inc | Verwendung von (-) Cetrizin zur Behandlung allergischer Rhinitis und Asthma. |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| US6469009B1 (en) | 1996-04-08 | 2002-10-22 | Ucb, S.A. | Pharmaceutical compositions for the treatment of rhinitis |
| BE1010094A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| WO1998055459A1 (en) | 1997-06-04 | 1998-12-10 | Azwell Inc. | Process for producing piperazinesulfonamide derivatives and salts thereof |
| EP0919550A1 (en) * | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
| GR990100135A (el) * | 1999-04-22 | 2000-12-29 | Genepharm �.�. | Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου |
| JP2002249487A (ja) * | 2001-02-22 | 2002-09-06 | Sumitomo Chem Co Ltd | ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。 |
| US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
| CA2514145A1 (en) | 2003-01-23 | 2004-08-05 | Ucb Farchim Sa | Piperazine derivatives and their use as synthesis intermediates |
| KR100503443B1 (ko) | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
| ES2326689T3 (es) * | 2005-03-03 | 2009-10-16 | Ucb Farchim, S.A. | Sales de piroglutamato y su uso en la resolucion optica de intermedios para la sintesis de dextrocetirizana y levocetirizana. |
| HU227325B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| SI22489A (sl) * | 2007-03-12 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za pripravo levocetirizina in njegovih intermediatov |
| WO2008110586A2 (en) | 2007-03-12 | 2008-09-18 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
| EP2167479B1 (en) | 2007-06-15 | 2013-09-11 | Symed Labs Limited | Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates |
| WO2009062036A2 (en) * | 2007-11-09 | 2009-05-14 | Dr. Reddy's Laboratories Ltd. | Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof |
| ES2361343T3 (es) | 2007-11-21 | 2011-06-16 | Synthon B.V. | Procedimiento para obtener n-(difenilmetil)piperazinas. |
| US7989623B2 (en) | 2007-11-21 | 2011-08-02 | Synthon Bv | Process for making n-(diphenylmethyl)piperazines |
| KR20110022635A (ko) | 2008-06-02 | 2011-03-07 | 시플라 리미티드 | 레보세티리진의 합성방법 및 이에 사용하기 위한 중간체 |
| WO2009150147A1 (en) * | 2008-06-11 | 2009-12-17 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
| KR100998067B1 (ko) | 2008-09-08 | 2010-12-03 | 주식회사 삼오제약 | 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법 |
| WO2010046908A2 (en) | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| WO2010107404A1 (en) | 2009-03-16 | 2010-09-23 | Mahmut Bilgic | Stable pharmaceutical combinations |
| TR201007652A2 (tr) | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Sinerjik etki. |
| TR201009398A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Fiziksel özellikleri geliştirilmiş tablet formülasyonları |
| WO2012101475A1 (en) | 2011-01-27 | 2012-08-02 | Jubilant Life Sciences Limited | An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate |
| CN103044355A (zh) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | 合成左西替利嗪的关键中间体及其制备方法 |
| KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
| KR102226833B1 (ko) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
| CN104045607B (zh) * | 2014-05-21 | 2016-04-13 | 丽珠医药集团股份有限公司 | 一种盐酸西替利嗪的纯化方法 |
| CN105924409B (zh) * | 2016-05-12 | 2019-01-08 | 浙江永宁药业股份有限公司 | 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法 |
| CN111205247B (zh) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | 左旋西替利嗪的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
-
1988
- 1988-11-23 GB GB888827391A patent/GB8827391D0/en active Pending
-
1989
- 1989-09-29 CA CA000614709A patent/CA1317300C/en not_active Expired - Fee Related
- 1989-11-20 GR GR890100770A patent/GR1000553B/el not_active IP Right Cessation
- 1989-11-21 PT PT92364A patent/PT92364B/pt not_active IP Right Cessation
- 1989-11-21 GB GB8926243A patent/GB2225321B/en not_active Expired - Lifetime
- 1989-11-22 HU HU896131A patent/HU205094B/hu not_active IP Right Cessation
- 1989-11-22 AT AT0266589A patent/AT398971B/de not_active IP Right Cessation
- 1989-11-22 DK DK198905867A patent/DK174543B1/da not_active IP Right Cessation
- 1989-11-22 FI FI895564A patent/FI91862C/fi not_active IP Right Cessation
- 1989-11-22 PL PL1989282410A patent/PL161379B1/pl unknown
- 1989-11-22 NO NO894651A patent/NO172342C/no not_active IP Right Cessation
- 1989-11-22 ES ES8903975A patent/ES2021907A6/es not_active Expired - Lifetime
- 1989-11-23 PH PH39570A patent/PH25982A/en unknown
- 1989-11-23 KR KR1019890017040A patent/KR970009728B1/ko not_active Expired - Fee Related
-
1992
- 1992-09-05 SG SG894/92A patent/SG89492G/en unknown
- 1992-12-03 HK HK958/92A patent/HK95892A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1671A patent/CY1671A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI91862C (fi) | 1994-08-25 |
| DK174543B1 (da) | 2003-05-19 |
| FI895564A0 (fi) | 1989-11-22 |
| NO172342B (no) | 1993-03-29 |
| CA1317300C (en) | 1993-05-04 |
| NO894651D0 (no) | 1989-11-22 |
| DK586789A (da) | 1990-05-24 |
| GB2225321A (en) | 1990-05-30 |
| FI91862B (fi) | 1994-05-13 |
| GB2225321B (en) | 1992-04-08 |
| AT398971B (de) | 1995-02-27 |
| CY1671A (en) | 1993-05-14 |
| GB8926243D0 (en) | 1990-01-10 |
| PL161379B1 (pl) | 1993-06-30 |
| HUT53627A (en) | 1990-11-28 |
| SG89492G (en) | 1992-12-04 |
| PT92364B (pt) | 1995-07-18 |
| HU896131D0 (en) | 1990-02-28 |
| PH25982A (en) | 1992-01-13 |
| HK95892A (en) | 1992-12-11 |
| GR1000553B (el) | 1992-08-26 |
| GB8827391D0 (en) | 1988-12-29 |
| DK586789D0 (da) | 1989-11-22 |
| NO172342C (no) | 1993-07-07 |
| HU205094B (en) | 1992-03-30 |
| GR890100770A (en) | 1990-12-31 |
| ATA266589A (de) | 1994-07-15 |
| ES2021907A6 (es) | 1991-11-16 |
| KR970009728B1 (ko) | 1997-06-17 |
| KR900007825A (ko) | 1990-06-02 |
| NO894651L (no) | 1990-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT92364A (pt) | Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridrato | |
| BR8903368A (pt) | Acido imidopercarboxilicos,processo para a sua preparacao e sua aplicacao | |
| BR8704814A (pt) | Processo para a preparacao de lactidios e processo para a preparacao de acido polilatico | |
| PT93089A (pt) | Processo para a preparacao de derivados do acido propenoico e de composicoes fungicidas que os contem | |
| BR8203901A (pt) | Acido polivinilmetilfosfinico processo para a sua preparacao e seu emprego | |
| PT82342B (pt) | Processo para a preparacao de derivados do acido hialuronico | |
| PT83684B (pt) | Processo para a preparacao de acidos heterociclil-oxoftalazinil-aceticos | |
| BR8907463A (pt) | Aparelho e processo para fabricacao de acido sulfurico | |
| BR8906200A (pt) | Processo para e preparacao de um ester de acido 2-cloro-piridino 3-carboxilico | |
| PT82769B (pt) | Processo para a preparacao de derivados de acidos tiazolidino-4(s)-caboxilicos | |
| PT87884A (pt) | Processo para a preparacao de acidos e esteres diazabicicloalquil em ponte-quinolono-carboxilicos | |
| PT84364B (pt) | Processo para a preparacao de derivados do acido 1h-imidazol-5-carboxilico e de composicoes herbicidas que os contem | |
| PT83332B (pt) | Processo aperfeicoado para a preparacao de acido tetrafluorobenzoico | |
| BR8806959A (pt) | Composto e processo para a preparacao do mesmo | |
| BR8903268A (pt) | Processo para a preparacao de um derivado de acido pirazol carboxilico | |
| PT82436B (pt) | Processo para a preparacao de acido 7-amino-3-propenilcefalosporanico e dos seus esteres | |
| PT80988B (pt) | Processo para a preparacao de derivados de acido quinolocarboxilico | |
| PT82903B (pt) | Processo para a preparacao dum derivado do acido quinolono-carboxilico | |
| BR8900621A (pt) | Processo para preparar acido n-fosfono-metil-imino-diacetico | |
| BR9203289A (pt) | Processo para a preparacao de acido 2,5-di-(fenilamino)-tereftalcio e seus estres dialquilicos | |
| BR8802825A (pt) | Processo para a preparacao de esteres do acido ortocarbonico e emprego | |
| BR9100618A (pt) | Processo para fermentacao concorrente de um l-amino-acido basico e um l-amino-acido acido | |
| PT83450B (pt) | Processo para a preparacao de esteres do acido di-hidrolisergico | |
| BR8603987A (pt) | Processo para a preparacao de um derivado de quinaldinamida e para a preparacao de um sal de adicao de acido do derivado de quinaldinamida | |
| PT89549A (pt) | Processo para a preparacao de hidrazinas e de derivados do acido hidroxamico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20090903 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20100303 |