ATA476175A - Verfahren zur herstellung von neuen benzimidazolinon-derivaten und ihren saureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen benzimidazolinon-derivaten und ihren saureadditionssalzen

Info

Publication number
ATA476175A
ATA476175A AT476175A AT476175A ATA476175A AT A476175 A ATA476175 A AT A476175A AT 476175 A AT476175 A AT 476175A AT 476175 A AT476175 A AT 476175A AT A476175 A ATA476175 A AT A476175A
Authority
AT
Austria
Prior art keywords
acid addition
addition salts
producing new
benzimidazolinone derivatives
benzimidazolinone
Prior art date
Application number
AT476175A
Other languages
English (en)
Other versions
AT345833B (de
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ATA476175A publication Critical patent/ATA476175A/de
Application granted granted Critical
Publication of AT345833B publication Critical patent/AT345833B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/766—Chemiluminescence; Bioluminescence of gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/10—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using catalysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y10T436/175383—Ammonia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/177692—Oxides of nitrogen
    • Y10T436/178459—Only nitrogen dioxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
AT476175A 1974-06-21 1975-06-20 Verfahren zur herstellung von neuen benzimidazolinon-derivaten und ihren saeure- additionssalzen AT345833B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/481,594 US3989707A (en) 1974-06-21 1974-06-21 Benzimidazolinone derivatives

Publications (2)

Publication Number Publication Date
ATA476175A true ATA476175A (de) 1978-02-15
AT345833B AT345833B (de) 1978-10-10

Family

ID=23912586

Family Applications (1)

Application Number Title Priority Date Filing Date
AT476175A AT345833B (de) 1974-06-21 1975-06-20 Verfahren zur herstellung von neuen benzimidazolinon-derivaten und ihren saeure- additionssalzen

Country Status (25)

Country Link
US (1) US3989707A (de)
JP (1) JPS5840553B2 (de)
AT (1) AT345833B (de)
AU (1) AU500910B2 (de)
BE (1) BE830403A (de)
CA (1) CA1053235A (de)
CH (1) CH615173A5 (de)
CS (1) CS190480B2 (de)
DE (1) DE2527261C2 (de)
DK (1) DK141751B (de)
ES (1) ES438714A1 (de)
FI (1) FI59589C (de)
FR (1) FR2275210A1 (de)
GB (1) GB1505173A (de)
HU (1) HU170435B (de)
IE (1) IE41383B1 (de)
IL (1) IL47529A (de)
NL (1) NL180587C (de)
NO (1) NO142400C (de)
PH (1) PH13604A (de)
PL (1) PL98220B1 (de)
SE (2) SE416298B (de)
SU (1) SU585811A3 (de)
YU (1) YU159475A (de)
ZA (1) ZA753968B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
NZ181256A (en) * 1975-07-21 1978-04-28 Janssen Pharmaceutica Nv 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4777265A (en) * 1986-03-11 1988-10-11 Basf Aktiengesellschaft Preparation of acrylates and methacrylates
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6180649B1 (en) 1996-04-19 2001-01-30 Nerosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
US6258825B1 (en) 1997-05-30 2001-07-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
CZ2002233A3 (cs) 1999-07-21 2002-04-17 Fujisawa Pharmaceutical Co., Ltd. Benzimidazolonové deriváty, způsob jejich výroby a farmaceutický prostředek
EP1451173A4 (de) * 2001-11-01 2005-10-26 Icagen Inc Piperidine
EP1937670A1 (de) * 2005-09-30 2008-07-02 Glaxo Group Limited Benzimidazolone mit aktivität am m1-rezeptor
ES2391107T3 (es) * 2005-09-30 2012-11-21 Glaxo Group Limited Compuestos que tienen actividad en el receptor M1 y sus usos en medicina
EP1943230B1 (de) * 2005-09-30 2010-12-22 Glaxo Group Limited Verbindungen mit aktivität am m1-rezeptor und ihre verwendung in der medizin
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
EP1997381A1 (de) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Verwendung einer Verbindung mit Monogalactosyldiacylglycerol-Synthase-Hemmungsaktivität als Herbizid oder Algizid, Herbizid- und Algizidzusammensetzungen
GB0718415D0 (en) * 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
AU2010282506A1 (en) * 2009-08-12 2012-03-08 Janssen Pharmaceutica Nv Process for the preparation of Cathepsin S inhibitors
JPWO2022260016A1 (de) * 2021-06-07 2022-12-15

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (de) * 1962-06-13
US3161645A (en) * 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
BE659364A (de) * 1964-02-05
US3799932A (en) * 1970-03-20 1974-03-26 Sumitomo Chemical Co Gamma-piperidinobutyrophenones
JPS5511671B2 (de) * 1971-08-26 1980-03-26

Also Published As

Publication number Publication date
CH615173A5 (de) 1980-01-15
IL47529A (en) 1978-10-31
NO142400B (no) 1980-05-05
NL7507368A (nl) 1975-12-23
DK141751B (da) 1980-06-09
HU170435B (de) 1977-06-28
SE416298B (sv) 1980-12-15
ES438714A1 (es) 1977-07-01
NL180587B (nl) 1986-10-16
DE2527261A1 (de) 1976-01-08
DK281975A (de) 1975-12-22
SE415298B (sv) 1980-09-22
BE830403A (nl) 1975-12-19
NL180587C (nl) 1987-03-16
JPS5113780A (de) 1976-02-03
SU585811A3 (ru) 1977-12-25
CA1053235A (en) 1979-04-24
AT345833B (de) 1978-10-10
FI751462A7 (de) 1975-12-22
PH13604A (en) 1980-08-05
CS190480B2 (en) 1979-05-31
PL98220B1 (pl) 1978-04-29
SE7507026L (sv) 1975-12-22
DK141751C (de) 1980-11-03
AU500910B2 (en) 1979-06-07
US3989707A (en) 1976-11-02
NO751735L (de) 1975-12-23
FI59589B (fi) 1981-05-29
DE2527261C2 (de) 1986-09-04
GB1505173A (en) 1978-03-30
JPS5840553B2 (ja) 1983-09-06
FR2275210A1 (fr) 1976-01-16
IL47529A0 (en) 1975-08-31
IE41383B1 (en) 1979-12-19
FI59589C (fi) 1981-09-10
YU159475A (en) 1982-02-28
SE7601636L (sv) 1976-02-13
ZA753968B (en) 1977-01-26
IE41383L (en) 1975-12-21
NO142400C (no) 1980-08-13
AU8113875A (en) 1976-11-18
FR2275210B1 (de) 1978-12-22

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee