ATA79999A - Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2 - Google Patents

Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2

Info

Publication number: ATA79999A
Authority: AT; Austria
Prior art keywords: ratio; nitrile; ketone; cefpodoxime proxetil; crystallization
Prior art date: 1999-05-05

Application number

AT0079999A

Other languages

English (en)

Other versions

AT408226B (de

Inventor

Eduard Dr Grill

Julia Greil

Hans Dr Ludescher

Klaus Dr Totschnig

Siegfried Wolf

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-05

Filing date

1999-05-05

Publication date

2001-02-15

1999-05-05 Priority to AT0079999A priority Critical patent/AT408226B/de

1999-05-05 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

2000-05-03 Priority to EP00943708A priority patent/EP1173444B1/de

2000-05-03 Priority to AT00943708T priority patent/ATE321054T1/de

2000-05-03 Priority to CN00807217A priority patent/CN1349539A/zh

2000-05-03 Priority to CN2006100925756A priority patent/CN1915998B/zh

2000-05-03 Priority to PCT/EP2000/003941 priority patent/WO2000066594A1/en

2000-05-03 Priority to JP2000615624A priority patent/JP5047418B2/ja

2000-05-03 Priority to DE60026845T priority patent/DE60026845T2/de

2000-05-03 Priority to AU58077/00A priority patent/AU5807700A/en

2000-05-03 Priority to KR1020017014064A priority patent/KR100698443B1/ko

2000-05-03 Priority to HK02104642.2A priority patent/HK1044759B/en

2001-02-15 Publication of ATA79999A publication Critical patent/ATA79999A/de

2001-09-25 Application granted granted Critical

2001-09-25 Publication of AT408226B publication Critical patent/AT408226B/de

2001-10-31 Priority to US10/001,544 priority patent/US6949641B2/en

Links

-1 2-FORMYLAMINOTHIAZOL-4-YL Chemical class 0.000 title 1
LTINZAODLRIQIX-FBXRGJNPSA-N cefpodoxime proxetil Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N/OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-FBXRGJNPSA-N 0.000 abstract 2
229960004797 cefpodoxime proxetil Drugs 0.000 abstract 2
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
150000002576 ketones Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
150000002825 nitriles Chemical class 0.000 abstract 2
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Hydrogenated Pyridines (AREA)
Thiazole And Isothizaole Compounds (AREA)

AT0079999A 1999-05-05 1999-05-05 Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2 AT408226B (de)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
AU58077/00A AU5807700A (en)	1999-05-05	2000-05-03	Crystalline beta-lactam intermediate
CN00807217A CN1349539A (zh)	1999-05-05	2000-05-03	β－内酰胺中间体结晶
CN2006100925756A CN1915998B (zh)	1999-05-05	2000-05-03	β-内酰胺中间体结晶
PCT/EP2000/003941 WO2000066594A1 (en)	1999-05-05	2000-05-03	Crystalline beta-lactam intermediate
JP2000615624A JP5047418B2 (ja)	1999-05-05	2000-05-03	結晶β−ラクタム中間体
EP00943708A EP1173444B1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate
AT00943708T ATE321054T1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate
KR1020017014064A KR100698443B1 (ko)	1999-05-05	2000-05-03	결정형 베타 락탐 중간체
HK02104642.2A HK1044759B (en)	1999-05-05	2000-05-03	Crystalline beta-lactam intermediate
DE60026845T DE60026845T2 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate
US10/001,544 US6949641B2 (en)	1999-05-05	2001-10-31	Crystalline β-lactam intermediate

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2

Publications (2)

Publication Number	Publication Date
ATA79999A true ATA79999A (de)	2001-02-15
AT408226B AT408226B (de)	2001-09-25

Family

ID=3500007

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
AT00943708T ATE321054T1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT00943708T ATE321054T1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate

Country Status (10)

Country	Link
US (1)	US6949641B2 (de)
EP (1)	EP1173444B1 (de)
JP (1)	JP5047418B2 (de)
KR (1)	KR100698443B1 (de)
CN (2)	CN1915998B (de)
AT (2)	AT408226B (de)
AU (1)	AU5807700A (de)
DE (1)	DE60026845T2 (de)
HK (1)	HK1044759B (de)
WO (1)	WO2000066594A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
EP1373276A4 (de) *	2001-02-27	2005-03-02	Ranbaxy Lab Ltd	Verfahren zur herstellung von cefpodoxim-proxetil
US20040197886A1 (en) *	2001-07-13	2004-10-07	Takahiro Ueda	Method of crystallizing reduced coenzyme Q10 from aqueous solution
US20060009639A1 (en) *	2002-11-22	2006-01-12	Orchid Chemicals & Pharmaceuticals Limited	Process for the preparation of cefpodoxime proxetil
US7280627B2 (en) *	2002-12-09	2007-10-09	The Johns Hopkins University	Constrained data-adaptive signal rejector
DE60222945T2 (de) *	2002-12-20	2008-02-07	Lupin Ltd., Mumbai	Verfahren zur herstellung von cefpodoxim-proxetil
WO2004060896A1 (en) *	2003-01-06	2004-07-22	Lupin Limited	A process for the manufacture of cefpodoxime proxetil

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4486425A (en) *	1980-09-30	1984-12-04	Sankyo Company Limited	7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5759894A (en) *	1980-09-30	1982-04-10	Sankyo Co Ltd	Cephalosporin for oral administration
JPS604189A (ja) *	1983-06-20	1985-01-10	Sankyo Co Ltd	β−ラクタム系化合物の製造法
JPS6067483A (ja) *	1983-09-24	1985-04-17	Sankyo Co Ltd	チアゾリオメチル置換基を有するセフアロスポリン誘導体
DE3804841A1 (de) *	1988-02-17	1989-08-31	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
DE3919259A1 (de) *	1989-06-13	1990-12-20	Hoechst Ag	Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
JPH0331286A (ja)	1989-06-27	1991-02-12	Sankyo Co Ltd	ホルミル基の脱離法
JP2961927B2 (ja) *	1991-02-12	1999-10-12	富士ゼロックス株式会社	ドラム周辺ユニットの通信エラー防止装置
YU48484B (sh) *	1991-05-24	1998-09-18	Hoechst Aktiengesellschaft	Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
EP0531875B1 (de) *	1991-09-07	2004-03-24	Aventis Pharma Deutschland GmbH	Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
IN191496B (de) *	1999-07-30	2003-12-06	Ranbaxy Lab Ltd
KR100342944B1 (ko) *	1999-11-08	2002-07-02	민경윤	고순도 세프포독심 프록세틸의 제조방법

1999
- 1999-05-05 AT AT0079999A patent/AT408226B/de not_active IP Right Cessation
2000
- 2000-05-03 AU AU58077/00A patent/AU5807700A/en not_active Abandoned
- 2000-05-03 EP EP00943708A patent/EP1173444B1/de not_active Expired - Lifetime
- 2000-05-03 DE DE60026845T patent/DE60026845T2/de not_active Expired - Lifetime
- 2000-05-03 AT AT00943708T patent/ATE321054T1/de not_active IP Right Cessation
- 2000-05-03 KR KR1020017014064A patent/KR100698443B1/ko not_active Expired - Fee Related
- 2000-05-03 HK HK02104642.2A patent/HK1044759B/en not_active IP Right Cessation
- 2000-05-03 CN CN2006100925756A patent/CN1915998B/zh not_active Expired - Fee Related
- 2000-05-03 WO PCT/EP2000/003941 patent/WO2000066594A1/en not_active Ceased
- 2000-05-03 CN CN00807217A patent/CN1349539A/zh active Pending
- 2000-05-03 JP JP2000615624A patent/JP5047418B2/ja not_active Expired - Fee Related
2001
- 2001-10-31 US US10/001,544 patent/US6949641B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2002543207A (ja)	2002-12-17
DE60026845D1 (de)	2006-05-11
DE60026845T2 (de)	2006-08-17
WO2000066594A1 (en)	2000-11-09
CN1349539A (zh)	2002-05-15
ATE321054T1 (de)	2006-04-15
JP5047418B2 (ja)	2012-10-10
CN1915998A (zh)	2007-02-21
HK1044759B (en)	2007-01-05
AU5807700A (en)	2000-11-17
KR100698443B1 (ko)	2007-03-23
EP1173444B1 (de)	2006-03-22
US20020065262A1 (en)	2002-05-30
CN1915998B (zh)	2012-09-05
HK1044759A1 (en)	2002-11-01
AT408226B (de)	2001-09-25
KR20020033616A (ko)	2002-05-07
US6949641B2 (en)	2005-09-27
EP1173444A1 (de)	2002-01-23

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Legal Events

Date	Code	Title	Description
2013-10-15	MM01	Lapse because of not paying annual fees	Effective date: 20130215