ATE321054T1 - Kristalline beta-lactam intermediate - Google Patents

Kristalline beta-lactam intermediate

Info

Publication number: ATE321054T1
Authority: AT; Austria
Prior art keywords: ratio; nitrile; ketone; crystalline; cefpodoxime proxetil
Prior art date: 1999-05-05

Application number

AT00943708T

Other languages

English (en)

Inventor

Julia Greil

Johannes Ludescher

Klaus Totschnig

Siegfried Wolf

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-05

Filing date

2000-05-03

Publication date

2006-04-15

2000-05-03 Application filed by Sandoz Ag filed Critical Sandoz Ag

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321054T1 publication Critical patent/ATE321054T1/de

Links

150000003952 β-lactams Chemical class 0.000 title 1
LTINZAODLRIQIX-FBXRGJNPSA-N cefpodoxime proxetil Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC)C(=O)OC(C)OC(=O)OC(C)C)C(=O)C(=N/OC)\C1=CSC(N)=N1 LTINZAODLRIQIX-FBXRGJNPSA-N 0.000 abstract 2
229960004797 cefpodoxime proxetil Drugs 0.000 abstract 2
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
150000002576 ketones Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
150000002825 nitriles Chemical class 0.000 abstract 2
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Hydrogenated Pyridines (AREA)
Thiazole And Isothizaole Compounds (AREA)

AT00943708T 1999-05-05 2000-05-03 Kristalline beta-lactam intermediate ATE321054T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
EP00943708A EP1173444B1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate

Publications (1)

Publication Number	Publication Date
ATE321054T1 true ATE321054T1 (de)	2006-04-15

Family

ID=3500007

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
AT00943708T ATE321054T1 (de)	1999-05-05	2000-05-03	Kristalline beta-lactam intermediate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT0079999A AT408226B (de)	1999-05-05	1999-05-05	Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2

Country Status (10)

Country	Link
US (1)	US6949641B2 (de)
EP (1)	EP1173444B1 (de)
JP (1)	JP5047418B2 (de)
KR (1)	KR100698443B1 (de)
CN (2)	CN1915998B (de)
AT (2)	AT408226B (de)
AU (1)	AU5807700A (de)
DE (1)	DE60026845T2 (de)
HK (1)	HK1044759B (de)
WO (1)	WO2000066594A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
EP1373276A4 (de) *	2001-02-27	2005-03-02	Ranbaxy Lab Ltd	Verfahren zur herstellung von cefpodoxim-proxetil
US20040197886A1 (en) *	2001-07-13	2004-10-07	Takahiro Ueda	Method of crystallizing reduced coenzyme Q10 from aqueous solution
US20060009639A1 (en) *	2002-11-22	2006-01-12	Orchid Chemicals & Pharmaceuticals Limited	Process for the preparation of cefpodoxime proxetil
US7280627B2 (en) *	2002-12-09	2007-10-09	The Johns Hopkins University	Constrained data-adaptive signal rejector
DE60222945T2 (de) *	2002-12-20	2008-02-07	Lupin Ltd., Mumbai	Verfahren zur herstellung von cefpodoxim-proxetil
WO2004060896A1 (en) *	2003-01-06	2004-07-22	Lupin Limited	A process for the manufacture of cefpodoxime proxetil

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4486425A (en) *	1980-09-30	1984-12-04	Sankyo Company Limited	7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
JPS5759894A (en) *	1980-09-30	1982-04-10	Sankyo Co Ltd	Cephalosporin for oral administration
JPS604189A (ja) *	1983-06-20	1985-01-10	Sankyo Co Ltd	β−ラクタム系化合物の製造法
JPS6067483A (ja) *	1983-09-24	1985-04-17	Sankyo Co Ltd	チアゾリオメチル置換基を有するセフアロスポリン誘導体
DE3804841A1 (de) *	1988-02-17	1989-08-31	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
DE3919259A1 (de) *	1989-06-13	1990-12-20	Hoechst Ag	Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
JPH0331286A (ja)	1989-06-27	1991-02-12	Sankyo Co Ltd	ホルミル基の脱離法
JP2961927B2 (ja) *	1991-02-12	1999-10-12	富士ゼロックス株式会社	ドラム周辺ユニットの通信エラー防止装置
YU48484B (sh) *	1991-05-24	1998-09-18	Hoechst Aktiengesellschaft	Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
EP0531875B1 (de) *	1991-09-07	2004-03-24	Aventis Pharma Deutschland GmbH	Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung
AT413383B (de) *	1998-01-09	2006-02-15	Sandoz Ag	Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
IN191496B (de) *	1999-07-30	2003-12-06	Ranbaxy Lab Ltd
KR100342944B1 (ko) *	1999-11-08	2002-07-02	민경윤	고순도 세프포독심 프록세틸의 제조방법

1999
- 1999-05-05 AT AT0079999A patent/AT408226B/de not_active IP Right Cessation
2000
- 2000-05-03 AU AU58077/00A patent/AU5807700A/en not_active Abandoned
- 2000-05-03 EP EP00943708A patent/EP1173444B1/de not_active Expired - Lifetime
- 2000-05-03 DE DE60026845T patent/DE60026845T2/de not_active Expired - Lifetime
- 2000-05-03 AT AT00943708T patent/ATE321054T1/de not_active IP Right Cessation
- 2000-05-03 KR KR1020017014064A patent/KR100698443B1/ko not_active Expired - Fee Related
- 2000-05-03 HK HK02104642.2A patent/HK1044759B/en not_active IP Right Cessation
- 2000-05-03 CN CN2006100925756A patent/CN1915998B/zh not_active Expired - Fee Related
- 2000-05-03 WO PCT/EP2000/003941 patent/WO2000066594A1/en not_active Ceased
- 2000-05-03 CN CN00807217A patent/CN1349539A/zh active Pending
- 2000-05-03 JP JP2000615624A patent/JP5047418B2/ja not_active Expired - Fee Related
2001
- 2001-10-31 US US10/001,544 patent/US6949641B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2002543207A (ja)	2002-12-17
ATA79999A (de)	2001-02-15
DE60026845D1 (de)	2006-05-11
DE60026845T2 (de)	2006-08-17
WO2000066594A1 (en)	2000-11-09
CN1349539A (zh)	2002-05-15
JP5047418B2 (ja)	2012-10-10
CN1915998A (zh)	2007-02-21
HK1044759B (en)	2007-01-05
AU5807700A (en)	2000-11-17
KR100698443B1 (ko)	2007-03-23
EP1173444B1 (de)	2006-03-22
US20020065262A1 (en)	2002-05-30
CN1915998B (zh)	2012-09-05
HK1044759A1 (en)	2002-11-01
AT408226B (de)	2001-09-25
KR20020033616A (ko)	2002-05-07
US6949641B2 (en)	2005-09-27
EP1173444A1 (de)	2002-01-23

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Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties