ATA856974A - Verfahren zur gewinnung der dimeren indolalkaloide vincristin, des-n-methylvinblastin und vinblastin - Google Patents

Verfahren zur gewinnung der dimeren indolalkaloide vincristin, des-n-methylvinblastin und vinblastin

Info

Publication number: ATA856974A
Authority: AT; Austria
Prior art keywords: methylvinblastin; calcoids; indolal; vincristin; vinblastin
Prior art date: 1973-10-24

Application number

AT856974A

Other languages

English (en)

Other versions

AT342215B (de

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-10-24

Filing date

1974-10-24

Publication date

1977-07-15

1974-10-24 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1977-07-15 Publication of ATA856974A publication Critical patent/ATA856974A/de

1978-03-28 Application granted granted Critical

1978-03-28 Publication of AT342215B publication Critical patent/AT342215B/de

Links

SBNOTUDDIXOFSN-UHFFFAOYSA-N 1h-indole-2-carbaldehyde Chemical compound C1=CC=C2NC(C=O)=CC2=C1 SBNOTUDDIXOFSN-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011084 recovery Methods 0.000 title 1
JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
229960003048 vinblastine Drugs 0.000 title 1
229960004528 vincristine Drugs 0.000 title 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT856974A 1973-10-24 1974-10-24 Verfahren zur gewinnung der dimeren indolalkaloide vincristin, des-n-methylvinblastin und vinblastin AT342215B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/409,225 US3932417A (en)	1973-10-24	1973-10-24	Dimeric indole alkaloid purification process

Publications (2)

Publication Number	Publication Date
ATA856974A true ATA856974A (de)	1977-07-15
AT342215B AT342215B (de)	1978-03-28

Family

ID=23619578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT856974A AT342215B (de)	1973-10-24	1974-10-24	Verfahren zur gewinnung der dimeren indolalkaloide vincristin, des-n-methylvinblastin und vinblastin

Country Status (25)

Country	Link
US (1)	US3932417A (de)
JP (1)	JPS5649919B2 (de)
AR (1)	AR200542A1 (de)
AT (1)	AT342215B (de)
BE (1)	BE819663A (de)
BG (1)	BG40316A3 (de)
CA (1)	CA1030963A (de)
CH (1)	CH606022A5 (de)
CS (1)	CS177884B2 (de)
DD (1)	DD115675A5 (de)
DE (1)	DE2442245A1 (de)
DK (1)	DK138541B (de)
ES (1)	ES431340A1 (de)
FR (1)	FR2249090B1 (de)
GB (1)	GB1479512A (de)
HU (1)	HU170134B (de)
IE (1)	IE39669B1 (de)
IL (1)	IL45553A (de)
NL (1)	NL184110C (de)
PH (1)	PH10811A (de)
PL (1)	PL95570B1 (de)
SE (1)	SE418185B (de)
SU (2)	SU884573A3 (de)
YU (1)	YU36610B (de)
ZA (1)	ZA745355B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU178084B (en) *	1977-05-31	1982-03-28	Richter Gedeon Vegyeszet	New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
US4749787A (en) *	1986-10-23	1988-06-07	Harbor Branch Oceanographic Institution, Inc.	Process of isolating vinblastine from the plant catharanthis roseus
HK1049787B (en)	1999-10-01	2014-07-25	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN100336817C (zh) *	2005-07-12	2007-09-12	东北林业大学	一种连续中压柱层析制备高纯度硫酸长春碱的方法
CN115124505B (zh) *	2022-08-01	2023-07-18	云南中烟工业有限责任公司	一种吲哚生物碱类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3225030A (en) *	1965-02-15	1965-12-21	Lilly Co Eli	Method of preparing leurosine and vincaleukoblastine
US3354163A (en) *	1966-12-15	1967-11-21	Eli Lillty And Company	Nu-desmethylvinblastine
DE2124023C3 (de) *	1970-05-27	1980-07-10	Richter Gedeon Vegyeszeti Gyar R.T., Budapest	Verfahren zur selektiven Gewinnung von Vinblastin, Vinleurosin und Vincristin oder von deren Sulfaten
BE793336A (fr) *	1972-12-05	1973-04-16	Richter Gedeon Vegyeszet	Procede pour augmenter le rendement en vincristine lors de l'isolement de la vincristine de parties de la plante vinca rosea l.

1973
- 1973-10-24 US US05/409,225 patent/US3932417A/en not_active Expired - Lifetime
1974
- 1974-08-19 IE IE1723/74A patent/IE39669B1/xx unknown
- 1974-08-20 ZA ZA00745355A patent/ZA745355B/xx unknown
- 1974-08-23 PH PH16202A patent/PH10811A/en unknown
- 1974-08-27 IL IL45553A patent/IL45553A/xx unknown
- 1974-08-29 CA CA208,126A patent/CA1030963A/en not_active Expired
- 1974-09-04 DE DE2442245A patent/DE2442245A1/de not_active Withdrawn
- 1974-09-06 YU YU2405/74A patent/YU36610B/xx unknown
- 1974-09-06 FR FR7430292A patent/FR2249090B1/fr not_active Expired
- 1974-09-09 BE BE1006167A patent/BE819663A/xx not_active IP Right Cessation
- 1974-09-12 DD DD181067A patent/DD115675A5/xx unknown
- 1974-09-12 CH CH1243174A patent/CH606022A5/xx not_active IP Right Cessation
- 1974-09-19 AR AR255655A patent/AR200542A1/es active
- 1974-09-24 SU SU742062709A patent/SU884573A3/ru active
- 1974-10-02 BG BG027829A patent/BG40316A3/xx unknown
- 1974-10-18 NL NLAANVRAGE7413724,A patent/NL184110C/xx not_active IP Right Cessation
- 1974-10-22 PL PL1974175028A patent/PL95570B1/pl unknown
- 1974-10-23 DK DK555374AA patent/DK138541B/da not_active IP Right Cessation
- 1974-10-23 SE SE7413357A patent/SE418185B/xx not_active IP Right Cessation
- 1974-10-23 GB GB45910/74A patent/GB1479512A/en not_active Expired
- 1974-10-24 CS CS7285A patent/CS177884B2/cs unknown
- 1974-10-24 AT AT856974A patent/AT342215B/de not_active IP Right Cessation
- 1974-10-24 HU HUEI569A patent/HU170134B/hu unknown
- 1974-10-24 JP JP12329574A patent/JPS5649919B2/ja not_active Expired
- 1974-10-24 ES ES431340A patent/ES431340A1/es not_active Expired
1979
- 1979-10-19 SU SU792833053A patent/SU1207396A3/ru active

Also Published As

Publication number	Publication date
SU1207396A3 (ru)	1986-01-23
DK138541C (de)	1979-02-26
SE7413357L (de)	1975-04-25
ZA745355B (en)	1976-03-31
PH10811A (en)	1977-09-07
PL95570B1 (pl)	1977-10-31
NL184110B (nl)	1988-11-16
FR2249090B1 (de)	1979-01-05
BG40316A3 (en)	1986-11-14
HU170134B (de)	1977-04-28
FR2249090A1 (de)	1975-05-23
JPS5070400A (de)	1975-06-11
DD115675A5 (de)	1975-10-12
AT342215B (de)	1978-03-28
IL45553A (en)	1979-01-31
SE418185B (sv)	1981-05-11
DK138541B (da)	1978-09-25
DK555374A (de)	1975-06-16
BE819663A (fr)	1975-03-10
CH606022A5 (de)	1978-10-13
ES431340A1 (es)	1976-11-01
GB1479512A (en)	1977-07-13
YU36610B (en)	1984-08-31
AU7262774A (en)	1976-02-26
NL7413724A (nl)	1975-04-28
AR200542A1 (es)	1974-11-15
JPS5649919B2 (de)	1981-11-25
IL45553A0 (en)	1974-11-29
IE39669L (en)	1975-04-24
US3932417A (en)	1976-01-13
NL184110C (nl)	1989-04-17
SU884573A3 (ru)	1981-11-23
DE2442245A1 (de)	1975-04-30
IE39669B1 (en)	1978-12-06
CS177884B2 (de)	1977-08-31
CA1030963A (en)	1978-05-09
YU240574A (en)	1982-02-25

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Legal Events

Date	Code	Title	Description
1995-10-15	ELA	Expired due to lapse of time