ATE100447T1 - 19-nor-vitamin-d-derivate. - Google Patents

19-nor-vitamin-d-derivate.

Info

Publication number: ATE100447T1
Authority: AT; Austria
Prior art keywords: vitamin; undifferentiated cells; cells; malignant; treatment
Prior art date: 1989-03-09

Application number

AT90302521T

Other languages

English (en)

Inventor

Hector F Deluca

Heinrich K Schnoes

Kato L Perlman

Rafal R Sicinski

Jean Martin Prahl

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-09

Filing date

1990-03-09

Publication date

1994-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26982778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE100447(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-16 Priority claimed from US07/481,354 external-priority patent/US5237110A/en

1990-03-09 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1994-02-15 Application granted granted Critical

1994-02-15 Publication of ATE100447T1 publication Critical patent/ATE100447T1/de

Links

PKFBWEUIKKCWEW-WEZTXPJVSA-N (1r,3r)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1C[C@@H](O)C[C@H](O)C1 PKFBWEUIKKCWEW-WEZTXPJVSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000003211 malignant effect Effects 0.000 abstract 2
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000007429 general method Methods 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90302521T 1989-03-09 1990-03-09 19-nor-vitamin-d-derivate. ATE100447T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32103089A	1989-03-09	1989-03-09
US07/481,354 US5237110A (en)	1989-03-09	1990-02-16	19-nor-vitamin d compounds

Publications (1)

Publication Number	Publication Date
ATE100447T1 true ATE100447T1 (de)	1994-02-15

Family

ID=26982778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90302521T ATE100447T1 (de)	1989-03-09	1990-03-09	19-nor-vitamin-d-derivate.

Country Status (8)

Country	Link
EP (1)	EP0387077B1 (de)
CN (1)	CN1033857C (de)
AT (1)	ATE100447T1 (de)
DE (3)	DE69006052T2 (de)
ES (1)	ES2062334T3 (de)
IE (1)	IE64526B1 (de)
NL (1)	NL300228I1 (de)
NZ (1)	NZ232734A (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5063221A (en) *	1989-04-05	1991-11-05	Chugai Seiyaku Kabushiki Kaisha	Treatment for hyperparathyroidism with use of vitamin d derivatives
AU649057B2 (en) *	1990-08-24	1994-05-12	Wisconsin Alumni Research Foundation	Methods and compositions containing vitamin D compounds for improvement of skin conditions
US5459136A (en) *	1990-08-24	1995-10-17	Wisconsin Alumni Research Foundation	Methods using vitamin D compounds for improvement of skin conditions
DE69130497T2 (de) *	1990-09-07	1999-04-22	Wisconsin Alumni Research Foundation, Madison, Wis.	Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
AU650751B2 (en) *	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) *	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
ATE143007T1 (de) *	1991-07-05	1996-10-15	Duphar Int Res	Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
CA2129120A1 (en) *	1992-01-29	1993-08-05	Bone Care International, Inc.	1.alpha.-hydroxy-24-epi-vitamin d4
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) *	1992-08-07	1996-02-15	Wisconsin Alumni Research Foundation	Preparation of 19-nor-vitamin D compounds
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
TW267161B (de) *	1992-11-20	1996-01-01	Hoffmann La Roche
DE69400495T2 (de) *	1993-04-05	1997-04-30	Wisconsin Alumni Res Found	19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
PT972762E (pt) *	1993-07-09	2004-02-27	Theramex	Novos analogos estruturais da vitamina d
DE69503394T2 (de) *	1994-01-20	1999-03-11	Duphar International Research B.V., Weesp	Vitamin-D-Derivate und Verfahren zu deren Herstellung
EP0793649B1 (de) *	1994-11-21	1999-02-03	Wisconsin Alumni Research Foundation	18,19-dinor-vitamin-d-derivate
DK0717034T3 (da) *	1994-12-14	1999-10-18	Duphar Int Res	Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
US5597815A (en) *	1995-07-13	1997-01-28	Wisconsin Alumni Research Foundation	Prevention of hyperphosphatemia in kidney disorder patients
AU1152997A (en) *	1995-12-28	1997-07-28	Chugai Seiyaku Kabushiki Kaisha	Malignant tumor metastasis inhibitors
US6869940B2 (en)	1995-12-28	2005-03-22	Chugai Seiyaku Kabushiki Kaisha	Malignant tumor metastasis inhibitors
US5891865A (en) *	1996-10-04	1999-04-06	Wisconsin Alumni Research Foundation	Treatment of arthritic disease induced by infectious agents
US5945410A (en) *	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
US5843928A (en) *	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en)	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6316642B1 (en)	1997-03-17	2001-11-13	Wisconsin Alumni Research Foundation	26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
ES2173586T3 (es) *	1997-05-23	2002-10-16	Basilea Pharmaceutica Ag	Derivados de ciclohexandiol.
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US6114317A (en)	1998-05-21	2000-09-05	Wisconsin Alumni Research Foundation	Method of locking 1α-OH of vitamin D compounds in axial orientation
US6806262B2 (en)	2000-05-31	2004-10-19	Wisconsin Alumni Research Foundation	2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
BRPI0409194A (pt)	2003-04-10	2006-04-11	Wisconsin Alumni Res Found	compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso
US6894037B2 (en)	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en)	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
EP1922303A2 (de) *	2005-07-18	2008-05-21	Teva Pharmaceutical Industries Ltd	Herstellung von paricalcitol
EP2010483A2 (de)	2006-04-05	2009-01-07	Wisconsin Alumni Research Foundation	1.alpha.-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen sowie verfahren zu ihrer herstellung und verwendung
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
US7491712B1 (en)	2007-12-10	2009-02-17	Formosa Laboratories, Inc.	Process for preparation of paricalcitol and intermediates thereof
US9212136B2 (en)	2008-07-22	2015-12-15	Azad Pharmaceuticals Ingredients Ag	Methods for producing paricalcitol
PL216135B1 (pl)	2009-08-07	2014-03-31	Inst Farmaceutyczny	Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
EP2545940A1 (de)	2011-07-14	2013-01-16	hameln rds gmbh	Parenterale Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4448726A (en) *	1983-05-11	1984-05-15	Wisconsin Alumni Research Foundation	Ring A- and triene-modified vitamin D compounds
DE3590021C2 (de) *	1984-01-30	1992-09-10	Wisconsin Alumni Res Found	1alpha-Hydroxyvitamin D-Derivat und dieses enthaltendes Arzneimittel
US4555364A (en) *	1984-11-01	1985-11-26	Wisconsin Alumni Research Foundation	Method for preparing 1-hydroxyvitamin D compounds
CA1314872C (en) *	1986-04-25	1993-03-23	Toshio Nishizawa	Fluorine derivatives of vitamin d _and process for producing the same

1990
- 1990-02-28 NZ NZ232734A patent/NZ232734A/xx unknown
- 1990-03-09 DE DE90302521T patent/DE69006052T2/de not_active Expired - Lifetime
- 1990-03-09 CN CN90101777.9A patent/CN1033857C/zh not_active Expired - Lifetime
- 1990-03-09 DE DE1990606052 patent/DE122006000018I1/de active Pending
- 1990-03-09 IE IE84090A patent/IE64526B1/en not_active IP Right Cessation
- 1990-03-09 DE DE122006000018C patent/DE122006000018I2/de active Active
- 1990-03-09 AT AT90302521T patent/ATE100447T1/de not_active IP Right Cessation
- 1990-03-09 ES ES90302521T patent/ES2062334T3/es not_active Expired - Lifetime
- 1990-03-09 EP EP90302521A patent/EP0387077B1/de not_active Expired - Lifetime
2006
- 2006-04-07 NL NL300228C patent/NL300228I1/nl unknown

Also Published As

Publication number	Publication date
NL300228I1 (nl)	2006-06-01
IE64526B1 (en)	1995-08-09
CN1046155A (zh)	1990-10-17
EP0387077B1 (de)	1994-01-19
DE69006052T2 (de)	1994-05-05
NZ232734A (en)	1991-11-26
EP0387077A1 (de)	1990-09-12
DE122006000018I2 (de)	2008-05-08
DE122006000018I1 (de)	2006-06-29
CN1033857C (zh)	1997-01-22
IE900840L (en)	1990-09-09
DE69006052D1 (de)	1994-03-03
ES2062334T3 (es)	1994-12-16

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE100447T1 (de)	1994-02-15	19-nor-vitamin-d-derivate.
HU896762D0 (en)	1990-03-28	Process for preparation of pyrimidine-derivatives and for manufacturing of pharmaceutical compositions containing these compounds
AU549481B2 (en)	1986-01-30	Hair growing agent
YU29099A (sh)	2002-06-19	Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
AP2000001881A0 (en)	2000-09-30	2-(Purine-9-YL)-tetrahydrofuran-3,4 4-diol derivatives.
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
BG104729A (en)	2001-04-30	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
ATE90342T1 (de)	1993-06-15	1-hydroxyvitamin d2-epimer und dessen derivate.
DK0412554T3 (da)	1994-12-12	Sustained-release-præparat til administration i hjernen
TR199700711T1 (xx)	1998-01-21	Ciltten ge�erek v�cuda giren form�lasyon.
IL68456A (en)	1989-09-28	Pharmaceutical compositions comprising perfluoro-substituted compounds as vehicles
EP0328634A4 (en)	1991-08-21	Pharmaceutical compositions for the treatment of psoriasis
ATE67495T1 (de)	1991-10-15	4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2thiazolamine und 4-(hexahydro-1-alkyl-3pyridinyl)-2-thiazolamine.
ATE528279T1 (de)	2011-10-15	3-butenyl-1-aminederivate und ihre verwendung als ih modulatoren von therapie für psychiatrische erkrankungen
ES545195A0 (es)	1986-01-16	Un procedimiento para preparar derivados de purina
IL111580A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
ATE239470T1 (de)	2003-05-15	Melatonin-derivate zur verwendung in der behandlung von desynchronisierungs-erkankungen
IE891407L (en)	1989-10-29	Side chain unsaturated 1-ó-hydroxyvitamin d homologs
ATE81130T1 (de)	1992-10-15	4,5,6,7-tetrahydroisothiazolo (4,5-c)pyridinderivate und isomere.
CS318690A3 (en)	1992-11-18	Pharmaceutical composition usable for depression therapy
IT8349055A0 (it)	1983-09-28	B-osso-l-carbammoil-pirrolpropionitrile, procedimento per la loro produzione, preparati farmaceutici con tenenti questi composti, nonche' il loro impiego terapeutico
EP0301449A3 (en)	1990-03-21	Enantiomers of propafenone-containing therapeutic agents
IL87867A (en)	1992-11-15	Preparation of pharmaceutical compositions containing a 2,6-diamino-3-phenyl-azo-pyridine derivative
DK0608648T3 (da)	1997-06-16	Højdoserede vitamin A-præparater
NO170331C (no)	1992-10-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive acyleringsprodukter av bis(2-imidazolin-2-ylhydrazoner)av 9,10-antracen- dikarboksaldehyd