ATE100447T1 - 19-nor-vitamin-d-derivate. - Google Patents

19-nor-vitamin-d-derivate.

Info

Publication number: ATE100447T1
Authority: AT; Austria
Prior art keywords: vitamin; undifferentiated cells; cells; malignant; treatment
Prior art date: 1989-03-09

Application number

AT90302521T

Other languages

English (en)

Inventor

Hector F Deluca

Heinrich K Schnoes

Kato L Perlman

Rafal R Sicinski

Jean Martin Prahl

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-09

Filing date

1990-03-09

Publication date

1994-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26982778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE100447(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-16 Priority claimed from US07/481,354 external-priority patent/US5237110A/en

1990-03-09 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1994-02-15 Application granted granted Critical

1994-02-15 Publication of ATE100447T1 publication Critical patent/ATE100447T1/de

Links

PKFBWEUIKKCWEW-WEZTXPJVSA-N (1r,3r)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1C[C@@H](O)C[C@H](O)C1 PKFBWEUIKKCWEW-WEZTXPJVSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000003211 malignant effect Effects 0.000 abstract 2
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000007429 general method Methods 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90302521T 1989-03-09 1990-03-09 19-nor-vitamin-d-derivate. ATE100447T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32103089A	1989-03-09	1989-03-09
US07/481,354 US5237110A (en)	1989-03-09	1990-02-16	19-nor-vitamin d compounds

Publications (1)

Publication Number	Publication Date
ATE100447T1 true ATE100447T1 (de)	1994-02-15

Family

ID=26982778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90302521T ATE100447T1 (de)	1989-03-09	1990-03-09	19-nor-vitamin-d-derivate.

Country Status (8)

Country	Link
EP (1)	EP0387077B1 (de)
CN (1)	CN1033857C (de)
AT (1)	ATE100447T1 (de)
DE (3)	DE69006052T2 (de)
ES (1)	ES2062334T3 (de)
IE (1)	IE64526B1 (de)
NL (1)	NL300228I1 (de)
NZ (1)	NZ232734A (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2229921B (en) *	1989-04-05	1992-12-16	Chugai Pharmaceutical Co Ltd	Treatment for hyperparathyroidism with use of vitamin d derivatives
AU649057B2 (en) *	1990-08-24	1994-05-12	Wisconsin Alumni Research Foundation	Methods and compositions containing vitamin D compounds for improvement of skin conditions
US5459136A (en) *	1990-08-24	1995-10-17	Wisconsin Alumni Research Foundation	Methods using vitamin D compounds for improvement of skin conditions
ATE173401T1 (de) *	1990-09-07	1998-12-15	Wisconsin Alumni Res Found	Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis
US5086191A (en) *	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
AU650751B2 (en) *	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
DE69213844T2 (de) *	1991-07-05	1997-04-10	Duphar Int Res	Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür
DE69318142T2 (de) *	1992-01-29	1998-09-17	Bone Care Int Inc	1 alpha-HYDROXY-24-(EPI)-VITAMIN D4
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) *	1992-08-07	1996-02-15	Wisconsin Alumni Research Foundation	Preparation of 19-nor-vitamin D compounds
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (de) *	1992-11-20	1996-01-01	Hoffmann La Roche
JP2898882B2 (ja) *	1993-04-05	1999-06-02	ウイスコンシンアラムナイリサーチフオンデーシヨン	２−位に置換基を有する１９−ノル−ビタミンｄ３化合物
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
AU699200B2 (en) *	1993-07-09	1998-11-26	Roger Bouillon	Novel structural analogues of vitamin D
DE69503394T2 (de) *	1994-01-20	1999-03-11	Duphar International Research B.V., Weesp	Vitamin-D-Derivate und Verfahren zu deren Herstellung
JPH10509715A (ja) *	1994-11-21	1998-09-22	ウィスコンシン・アルムニ・リサーチ・ファウンデーション	１８，１９−ジノル−ビタミンｄ化合物
ATE178596T1 (de) *	1994-12-14	1999-04-15	Duphar Int Res	Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen
US5597815A (en) *	1995-07-13	1997-01-28	Wisconsin Alumni Research Foundation	Prevention of hyperphosphatemia in kidney disorder patients
ATE290869T1 (de)	1995-12-28	2005-04-15	Chugai Pharmaceutical Co Ltd	Verwendung von vitamin d derivaten zur herstellung eines medikaments zur behandlung von bösartigen tumormetastase
US6869940B2 (en)	1995-12-28	2005-03-22	Chugai Seiyaku Kabushiki Kaisha	Malignant tumor metastasis inhibitors
US5891865A (en) *	1996-10-04	1999-04-06	Wisconsin Alumni Research Foundation	Treatment of arthritic disease induced by infectious agents
US5843928A (en) *	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) *	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
US6316642B1 (en)	1997-03-17	2001-11-13	Wisconsin Alumni Research Foundation	26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6392071B1 (en)	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
AU7653998A (en) *	1997-05-23	1998-12-11	F. Hoffmann-La Roche Ag	Cyclohexanediol derivatives
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US6114317A (en)	1998-05-21	2000-09-05	Wisconsin Alumni Research Foundation	Method of locking 1α-OH of vitamin D compounds in axial orientation
ES2309069T3 (es)	2000-05-31	2008-12-16	Wisconsin Alumni Research Foundation	Compuestos de 2-etil y 2-etiliden-19-nor-vitamina d.
KR20050120787A (ko)	2003-04-10	2005-12-23	위스콘신 얼럼나이 리서어치 화운데이션	2-프로필리덴-19-노르-비타민 ｄ 화합물
US6894037B2 (en)	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en)	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
CN101223135A (zh) *	2005-07-18	2008-07-16	特瓦制药工业有限公司	帕立骨化醇的制备
EP2010483A2 (de)	2006-04-05	2009-01-07	Wisconsin Alumni Research Foundation	1.alpha.-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen sowie verfahren zu ihrer herstellung und verwendung
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
US7491712B1 (en)	2007-12-10	2009-02-17	Formosa Laboratories, Inc.	Process for preparation of paricalcitol and intermediates thereof
US9212136B2 (en)	2008-07-22	2015-12-15	Azad Pharmaceuticals Ingredients Ag	Methods for producing paricalcitol
PL216135B1 (pl)	2009-08-07	2014-03-31	Inst Farmaceutyczny	Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
EP2545940A1 (de)	2011-07-14	2013-01-16	hameln rds gmbh	Parenterale Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4448726A (en) *	1983-05-11	1984-05-15	Wisconsin Alumni Research Foundation	Ring A- and triene-modified vitamin D compounds
NL8520009A (nl) *	1984-01-30	1985-12-02	Wisconsin Alumni Res Found	1alfa.25-dihydroxy-22z-dehydrovitamine d verbinding.
US4555364A (en) *	1984-11-01	1985-11-26	Wisconsin Alumni Research Foundation	Method for preparing 1-hydroxyvitamin D compounds
CA1314872C (en) *	1986-04-25	1993-03-23	Toshio Nishizawa	Fluorine derivatives of vitamin d _and process for producing the same

1990
- 1990-02-28 NZ NZ232734A patent/NZ232734A/xx unknown
- 1990-03-09 EP EP90302521A patent/EP0387077B1/de not_active Expired - Lifetime
- 1990-03-09 CN CN90101777.9A patent/CN1033857C/zh not_active Expired - Lifetime
- 1990-03-09 IE IE84090A patent/IE64526B1/en not_active IP Right Cessation
- 1990-03-09 ES ES90302521T patent/ES2062334T3/es not_active Expired - Lifetime
- 1990-03-09 DE DE90302521T patent/DE69006052T2/de not_active Expired - Lifetime
- 1990-03-09 AT AT90302521T patent/ATE100447T1/de not_active IP Right Cessation
- 1990-03-09 DE DE1990606052 patent/DE122006000018I1/de active Pending
- 1990-03-09 DE DE122006000018C patent/DE122006000018I2/de active Active
2006
- 2006-04-07 NL NL300228C patent/NL300228I1/nl unknown

Also Published As

Publication number	Publication date
EP0387077B1 (de)	1994-01-19
EP0387077A1 (de)	1990-09-12
DE69006052D1 (de)	1994-03-03
DE69006052T2 (de)	1994-05-05
IE64526B1 (en)	1995-08-09
CN1033857C (zh)	1997-01-22
DE122006000018I2 (de)	2008-05-08
CN1046155A (zh)	1990-10-17
DE122006000018I1 (de)	2006-06-29
NZ232734A (en)	1991-11-26
ES2062334T3 (es)	1994-12-16
IE900840L (en)	1990-09-09
NL300228I1 (nl)	2006-06-01

Legal Events

Date	Code	Title	Description
1994-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE122006000018I2 (de)	2008-05-08	19-Nor-Vitamin-D-Derivate.
HU896762D0 (en)	1990-03-28	Process for preparation of pyrimidine-derivatives and for manufacturing of pharmaceutical compositions containing these compounds
YU29099A (sh)	2002-06-19	Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
GR3019450T3 (en)	1996-06-30	Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system
FI920856A7 (fi)	1992-02-26	Bioerodoituvia polymeerejä, jotka soveltuvat terapeuttisten aineiden s äädeltyyn vapauttamiseen
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
BG104729A (en)	2001-04-30	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
ATE90342T1 (de)	1993-06-15	1-hydroxyvitamin d2-epimer und dessen derivate.
DE3779053D1 (de)	1992-06-17
DK0412554T3 (da)	1994-12-12	Sustained-release-præparat til administration i hjernen
TR199700711T1 (xx)	1998-01-21	Ciltten ge�erek v�cuda giren form�lasyon.
IL68456A (en)	1989-09-28	Pharmaceutical compositions comprising perfluoro-substituted compounds as vehicles
ES2123505T3 (es)	1999-01-16	Nuevo uso de compuestos de 19-nor-vitamina d 1alfa-hidroxilada para tratar la psoriasis.
IL83775A0 (en)	1988-02-29	Fumaramide derivatives and pharmaceutical compositions containing them for treating skin diseases
DE3681581D1 (de)	1991-10-24	4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamine und 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamine.
ATE528279T1 (de)	2011-10-15	3-butenyl-1-aminederivate und ihre verwendung als ih modulatoren von therapie für psychiatrische erkrankungen
ES545194A0 (es)	1986-04-01	Un procedimiento para preparar derivados de purina
IL111580A (en)	1999-10-28	Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
ATE239470T1 (de)	2003-05-15	Melatonin-derivate zur verwendung in der behandlung von desynchronisierungs-erkankungen
ES2113020T3 (es)	1998-04-16	Analogos de vitamina d3.
DE68903019D1 (de)	1992-11-05	4,5,6,7-tetrahydroisothiazolo (4,5-c)pyridin-derivate und isomere.
DK0486586T3 (da)	1994-10-24	Kynurensyrederivater, fremstilling deraf og farmaceutiske præparater, der indeholder dem
IT8349055A0 (it)	1983-09-28	B-osso-l-carbammoil-pirrolpropionitrile, procedimento per la loro produzione, preparati farmaceutici con tenenti questi composti, nonche' il loro impiego terapeutico
ZA873928B (en)	1988-02-24	Topical methotrexate preparation for the treatment of hyperproliferative epithelial disease
EP0301449A3 (en)	1990-03-21	Enantiomers of propafenone-containing therapeutic agents