ES2062334T3 - Compuestos de 19-nor-vitamina d. - Google Patents

Compuestos de 19-nor-vitamina d.

Info

Publication number
ES2062334T3
ES2062334T3 ES90302521T ES90302521T ES2062334T3 ES 2062334 T3 ES2062334 T3 ES 2062334T3 ES 90302521 T ES90302521 T ES 90302521T ES 90302521 T ES90302521 T ES 90302521T ES 2062334 T3 ES2062334 T3 ES 2062334T3
Authority
ES
Spain
Prior art keywords
vitamin
cells
treatment
compounds
malignant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302521T
Other languages
English (en)
Inventor
Hector F Deluca
Heinrich K Schnoes
Kato L Perlman
Rafal R Sicinski
Jean Martin Prahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26982778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2062334(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/481,354 external-priority patent/US5237110A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2062334T3 publication Critical patent/ES2062334T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTE INVENTO PROVEE UNA CLASE DE COMPONENTES RELACIONADOS DE VITAMINA D, A SABER LOS ANALOGOS VITAMINA D-NOR-19-HIDROXI-1A, COMO TAMBIEN UN METODO GENERAL PARA SU SINTESIS QUIMICA. LOS COMPONENTES EXHIBEN ACTIVIDAD PRONUNCIADA EN ARRESTAR LA PROLIFERACION DE CELULAS INDIFERENCIADAS, INCLUYENDO CELULAS MALIGNAS, Y EN INDUCIR SU DIFERENCIACION, Y ASI REPRESENTA NUEVOS AGENTES TERAPEUTICOS PARA EL TRATAMIENTO DE MALIGNOS Y OTRAS ENFERMEDADES CARACTERIZADAS POR EL CRECIMIENTO PROLIFERATIVO DE CELULAS INDIFERENCIADAS. TAMBIEN SON PROVISTOS LAS FORMULAS PARA USO TERAPEUTICO Y METODOS DE TRATAMIENTO.
ES90302521T 1989-03-09 1990-03-09 Compuestos de 19-nor-vitamina d. Expired - Lifetime ES2062334T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32103089A 1989-03-09 1989-03-09
US07/481,354 US5237110A (en) 1989-03-09 1990-02-16 19-nor-vitamin d compounds

Publications (1)

Publication Number Publication Date
ES2062334T3 true ES2062334T3 (es) 1994-12-16

Family

ID=26982778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302521T Expired - Lifetime ES2062334T3 (es) 1989-03-09 1990-03-09 Compuestos de 19-nor-vitamina d.

Country Status (8)

Country Link
EP (1) EP0387077B1 (es)
CN (1) CN1033857C (es)
AT (1) ATE100447T1 (es)
DE (3) DE69006052T2 (es)
ES (1) ES2062334T3 (es)
IE (1) IE64526B1 (es)
NL (1) NL300228I1 (es)
NZ (1) NZ232734A (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5063221A (en) * 1989-04-05 1991-11-05 Chugai Seiyaku Kabushiki Kaisha Treatment for hyperparathyroidism with use of vitamin d derivatives
AU649057B2 (en) * 1990-08-24 1994-05-12 Wisconsin Alumni Research Foundation Methods and compositions containing vitamin D compounds for improvement of skin conditions
US5459136A (en) * 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
DE69130497T2 (de) * 1990-09-07 1999-04-22 Wisconsin Alumni Research Foundation, Madison, Wis. Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
CA2129120A1 (en) * 1992-01-29 1993-08-05 Bone Care International, Inc. 1.alpha.-hydroxy-24-epi-vitamin d4
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (es) * 1992-11-20 1996-01-01 Hoffmann La Roche
DE69400495T2 (de) * 1993-04-05 1997-04-30 Wisconsin Alumni Res Found 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
PT972762E (pt) * 1993-07-09 2004-02-27 Theramex Novos analogos estruturais da vitamina d
DE69503394T2 (de) * 1994-01-20 1999-03-11 Duphar International Research B.V., Weesp Vitamin-D-Derivate und Verfahren zu deren Herstellung
EP0793649B1 (en) * 1994-11-21 1999-02-03 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
DK0717034T3 (da) * 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
US5597815A (en) * 1995-07-13 1997-01-28 Wisconsin Alumni Research Foundation Prevention of hyperphosphatemia in kidney disorder patients
AU1152997A (en) * 1995-12-28 1997-07-28 Chugai Seiyaku Kabushiki Kaisha Malignant tumor metastasis inhibitors
US6869940B2 (en) 1995-12-28 2005-03-22 Chugai Seiyaku Kabushiki Kaisha Malignant tumor metastasis inhibitors
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
ES2173586T3 (es) * 1997-05-23 2002-10-16 Basilea Pharmaceutica Ag Derivados de ciclohexandiol.
US5939406A (en) * 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US6806262B2 (en) 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
BRPI0409194A (pt) 2003-04-10 2006-04-11 Wisconsin Alumni Res Found compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso
US6894037B2 (en) 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en) 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
EP1922303A2 (en) * 2005-07-18 2008-05-21 Teva Pharmaceutical Industries Ltd Purification of paricalcitol
EP2010483A2 (en) 2006-04-05 2009-01-07 Wisconsin Alumni Research Foundation 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US7491712B1 (en) 2007-12-10 2009-02-17 Formosa Laboratories, Inc. Process for preparation of paricalcitol and intermediates thereof
US9212136B2 (en) 2008-07-22 2015-12-15 Azad Pharmaceuticals Ingredients Ag Methods for producing paricalcitol
PL216135B1 (pl) 2009-08-07 2014-03-31 Inst Farmaceutyczny Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
EP2545940A1 (de) 2011-07-14 2013-01-16 hameln rds gmbh Parenterale Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
DE3590021C2 (de) * 1984-01-30 1992-09-10 Wisconsin Alumni Res Found 1alpha-Hydroxyvitamin D-Derivat und dieses enthaltendes Arzneimittel
US4555364A (en) * 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
CA1314872C (en) * 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same

Also Published As

Publication number Publication date
NL300228I1 (nl) 2006-06-01
IE64526B1 (en) 1995-08-09
CN1046155A (zh) 1990-10-17
EP0387077B1 (en) 1994-01-19
DE69006052T2 (de) 1994-05-05
NZ232734A (en) 1991-11-26
EP0387077A1 (en) 1990-09-12
ATE100447T1 (de) 1994-02-15
DE122006000018I2 (de) 2008-05-08
DE122006000018I1 (de) 2006-06-29
CN1033857C (zh) 1997-01-22
IE900840L (en) 1990-09-09
DE69006052D1 (de) 1994-03-03

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