ATE102823T1 - Magnetisierbare kern-schale-mikrokugeln, bestehend aus vernetztem organopolysiloxan, verfahren zu ihrer herstellung und ihre verwendung in der biologie. - Google Patents
Magnetisierbare kern-schale-mikrokugeln, bestehend aus vernetztem organopolysiloxan, verfahren zu ihrer herstellung und ihre verwendung in der biologie.Info
- Publication number
- ATE102823T1 ATE102823T1 AT90420556T AT90420556T ATE102823T1 AT E102823 T1 ATE102823 T1 AT E102823T1 AT 90420556 T AT90420556 T AT 90420556T AT 90420556 T AT90420556 T AT 90420556T AT E102823 T1 ATE102823 T1 AT E102823T1
- Authority
- AT
- Austria
- Prior art keywords
- shell
- magnetisable
- microballs
- biology
- production
- Prior art date
Links
- 229920001296 polysiloxane Polymers 0.000 title abstract 3
- 239000011258 core-shell material Substances 0.000 title abstract 2
- 239000011806 microball Substances 0.000 title 1
- 239000000945 filler Substances 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
- G01N2446/64—Magnetic material dispersed in oil drop
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
- G01N2446/66—Magnetic material dispersed in surfactant
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
- Y10T428/2995—Silane, siloxane or silicone coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Silicon Polymers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Soft Magnetic Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8917232A FR2656318B1 (fr) | 1989-12-27 | 1989-12-27 | Microspheres "core-shell" magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE102823T1 true ATE102823T1 (de) | 1994-04-15 |
Family
ID=9388997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90420556T ATE102823T1 (de) | 1989-12-27 | 1990-12-20 | Magnetisierbare kern-schale-mikrokugeln, bestehend aus vernetztem organopolysiloxan, verfahren zu ihrer herstellung und ihre verwendung in der biologie. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5232782A (de) |
| EP (1) | EP0436450B1 (de) |
| JP (1) | JPH0737572B2 (de) |
| AT (1) | ATE102823T1 (de) |
| AU (1) | AU6849490A (de) |
| CA (1) | CA2033145A1 (de) |
| DE (1) | DE69007456T2 (de) |
| DK (1) | DK0436450T3 (de) |
| ES (1) | ES2052224T3 (de) |
| FI (1) | FI906383A7 (de) |
| FR (1) | FR2656318B1 (de) |
| IE (1) | IE904372A1 (de) |
| NO (1) | NO178549C (de) |
| PT (1) | PT96327A (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0699721B1 (de) * | 1994-09-01 | 2002-05-15 | Toda Kogyo Corporation | Mit modifizierten Polysiloxan beschichtete anorganische Teilchen |
| US5684130A (en) * | 1995-06-05 | 1997-11-04 | Solid Phase Sciences Corporation | Process for synthesis of organic compounds using magnetic particles |
| US5834121A (en) * | 1996-01-16 | 1998-11-10 | Solid Phase Sciences Corp. | Composite magnetic beads |
| WO2001001145A1 (fr) * | 1998-12-28 | 2001-01-04 | Kyowa Medex Co., Ltd. | Supports d'immunoessai et phases solides d'immunoessai utilisant ces supports |
| US6423410B1 (en) | 1998-09-04 | 2002-07-23 | Mds Proteomics, Inc. | Ultrasonically generated paramagnetic polymer particles |
| US5973138A (en) | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
| GB2355012B (en) * | 1999-10-05 | 2004-01-14 | Solid Phase Sciences Corp | Paramagnetic polymer practice |
| AU2001266979A1 (en) * | 2000-06-19 | 2002-01-02 | The University Of Iowa Research Foundation | New magnetic materials, metallic particles and method of making same |
| DE10044635A1 (de) * | 2000-09-08 | 2002-04-04 | Henkel Kgaa | Transparente Wirkstoffkapseln |
| AU2003215388A1 (en) | 2002-02-22 | 2003-09-09 | Purdue Research Foundation | Magnetic nanomaterials and methods for detection of biological materials |
| EP1532274A4 (de) * | 2002-06-28 | 2006-09-27 | Purdue Research Foundation | Magnetische nanomaterialien und verfahren zum nachweis biologischer materialien |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| CN100439515C (zh) * | 2003-03-03 | 2008-12-03 | 清华大学 | 一种核酸分析芯片实验室系统与应用 |
| CN1280428C (zh) * | 2003-05-19 | 2006-10-18 | 清华大学 | 一种基于微小颗粒的生物芯片系统及其应用 |
| CN100494399C (zh) * | 2003-06-30 | 2009-06-03 | 清华大学 | 一种基于dna芯片的基因分型方法及其应用 |
| GB0414159D0 (en) * | 2004-06-23 | 2004-07-28 | Smith Adrian | Process for manufacture of microbeads |
| JP4811565B2 (ja) * | 2005-03-31 | 2011-11-09 | Ｊｓｒ株式会社 | 多孔質表面を有する磁性粒子およびその製造方法、生化学用担体、ならびにビオチン類結合用粒子 |
| WO2008048271A2 (en) | 2005-10-24 | 2008-04-24 | Magsense Life Sciences, Inc. | Polymer coated microparticles |
| FR2910284B1 (fr) * | 2006-12-20 | 2009-04-17 | Oreal | Produit cosmetique comprenant des composes silicones et un polymere amphiphile |
| FR2910345A1 (fr) * | 2006-12-20 | 2008-06-27 | Oreal | Particules coeur/ecorce a base de composes silicones |
| DE102007031689A1 (de) * | 2007-07-06 | 2009-01-08 | Evonik Goldschmidt Gmbh | Enzympräparate |
| WO2013030240A1 (en) * | 2011-08-29 | 2013-03-07 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Phase transfer reactions |
| CN103933903B (zh) * | 2014-03-31 | 2017-01-04 | 清华大学 | 制备空心结构纳米有机硅微球的方法 |
| JP6182520B2 (ja) * | 2014-12-01 | 2017-08-16 | 三洋化成工業株式会社 | 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬 |
| JP6994021B2 (ja) | 2016-08-26 | 2022-01-14 | ジュノー セラピューティクス インコーポレイテッド | 細胞組成物中に存在する粒子を計数する方法 |
| SG11202000606TA (en) | 2017-07-29 | 2020-02-27 | Juno Therapeutics Inc | Reagents for expanding cells expressing recombinant receptors |
| MA52114A (fr) | 2018-02-28 | 2021-01-06 | Juno Therapeutics Inc | Procédés de détection de particules présentes dans une composition cellulaire |
| US20200041518A1 (en) | 2018-08-03 | 2020-02-06 | CellMax Life, Inc. | Lipid vesicle-coated magnetic beads and uses of the same |
| CN117321200A (zh) | 2021-03-22 | 2023-12-29 | 朱诺治疗学股份有限公司 | 评估病毒载体颗粒效力的方法 |
| AU2022241654A1 (en) | 2021-03-22 | 2023-09-28 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1313846A (fr) * | 1960-11-07 | 1963-01-04 | Ici Ltd | Fabrication de composés d'organosilicium |
| US3220972A (en) * | 1962-07-02 | 1965-11-30 | Gen Electric | Organosilicon process using a chloroplatinic acid reaction product as the catalyst |
| US3159601A (en) * | 1962-07-02 | 1964-12-01 | Gen Electric | Platinum-olefin complex catalyzed addition of hydrogen- and alkenyl-substituted siloxanes |
| US3159662A (en) * | 1962-07-02 | 1964-12-01 | Gen Electric | Addition reaction |
| US3296291A (en) * | 1962-07-02 | 1967-01-03 | Gen Electric | Reaction of silanes with unsaturated olefinic compounds |
| US3480555A (en) * | 1964-05-11 | 1969-11-25 | Diamond Shamrock Corp | Sols of gamma ferric oxide and their preparation |
| FR88676E (fr) * | 1964-08-05 | 1967-03-10 | Ici Ltd | Fabrication de composés d'organosilicium |
| FR1480409A (fr) * | 1965-05-17 | 1967-05-12 | Dow Corning | Nouveaux types de catalyseurs pour la réaction de groupes hydrogénés de silicium contenant trois liaisons, avec des composés organiques contenant une liaison non saturée aliphatique |
| US3436366A (en) * | 1965-12-17 | 1969-04-01 | Gen Electric | Silicone potting compositions comprising mixtures of organopolysiloxanes containing vinyl groups |
| US3344111A (en) * | 1966-09-28 | 1967-09-26 | Gen Electric | Preparation of stable copolymerizable organosilicon compositions containing a platinum catalyst and an acrylonitrile type compound |
| US3814730A (en) * | 1970-08-06 | 1974-06-04 | Gen Electric | Platinum complexes of unsaturated siloxanes and platinum containing organopolysiloxanes |
| US3715334A (en) * | 1970-11-27 | 1973-02-06 | Gen Electric | Platinum-vinylsiloxanes |
| US3775452A (en) * | 1971-04-28 | 1973-11-27 | Gen Electric | Platinum complexes of unsaturated siloxanes and platinum containing organopolysiloxanes |
| GB1476314A (en) * | 1973-06-23 | 1977-06-10 | Dow Corning Ltd | Coating process |
| US4094804A (en) * | 1974-08-19 | 1978-06-13 | Junzo Shimoiizaka | Method for preparing a water base magnetic fluid and product |
| US4177317A (en) * | 1975-12-15 | 1979-12-04 | Basf Aktiengesellschaft | Stabilization of chromium dioxide magnetic pigments |
| US4272601A (en) * | 1978-06-06 | 1981-06-09 | Konishiroku Photo Industry Co., Ltd. | Coated developer carrier for electrophotography |
| DE3002477A1 (de) * | 1979-02-02 | 1980-08-07 | Walker Scient Inc | Praeparat zur behandlung des magendarmkanals |
| NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4695392A (en) * | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4677003A (en) * | 1985-04-30 | 1987-06-30 | Rohm And Haas Company | Microsuspension process for preparing solvent core sequential polymer dispersion |
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| FR2618084B1 (fr) * | 1987-07-15 | 1989-11-10 | Rhone Poulenc Chimie | Microspheres magnetisables a base de polysiloxane, leur procede de preparation et leur application en biologie |
| JP2618663B2 (ja) * | 1987-11-30 | 1997-06-11 | 東レ・ダウコーニング・シリコーン株式会社 | 磁性シリコーンゴム粉状物の製造方法 |
| FR2624873B1 (fr) * | 1987-12-18 | 1992-01-10 | Rhone Poulenc Chimie | Particules composites magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie |
-
1989
- 1989-12-27 FR FR8917232A patent/FR2656318B1/fr not_active Expired - Fee Related
-
1990
- 1990-12-04 IE IE437290A patent/IE904372A1/en unknown
- 1990-12-20 ES ES90420556T patent/ES2052224T3/es not_active Expired - Lifetime
- 1990-12-20 NO NO905503A patent/NO178549C/no not_active IP Right Cessation
- 1990-12-20 AT AT90420556T patent/ATE102823T1/de not_active IP Right Cessation
- 1990-12-20 DE DE69007456T patent/DE69007456T2/de not_active Expired - Fee Related
- 1990-12-20 DK DK90420556.4T patent/DK0436450T3/da active
- 1990-12-20 EP EP90420556A patent/EP0436450B1/de not_active Expired - Lifetime
- 1990-12-21 AU AU68494/90A patent/AU6849490A/en not_active Abandoned
- 1990-12-21 PT PT96327A patent/PT96327A/pt not_active Application Discontinuation
- 1990-12-21 FI FI906383A patent/FI906383A7/fi not_active Application Discontinuation
- 1990-12-24 CA CA002033145A patent/CA2033145A1/fr not_active Abandoned
- 1990-12-26 JP JP2413980A patent/JPH0737572B2/ja not_active Expired - Fee Related
- 1990-12-27 US US07/634,910 patent/US5232782A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2656318B1 (fr) | 1994-02-04 |
| ES2052224T3 (es) | 1994-07-01 |
| DK0436450T3 (da) | 1994-07-18 |
| JPH04279664A (ja) | 1992-10-05 |
| NO905503D0 (no) | 1990-12-20 |
| IE904372A1 (en) | 1991-07-03 |
| FI906383A0 (fi) | 1990-12-21 |
| NO905503L (no) | 1991-06-28 |
| EP0436450B1 (de) | 1994-03-16 |
| NO178549C (no) | 1996-04-17 |
| FI906383L (fi) | 1991-06-28 |
| AU6849490A (en) | 1991-07-04 |
| FI906383A7 (fi) | 1991-06-28 |
| NO178549B (no) | 1996-01-08 |
| EP0436450A1 (de) | 1991-07-10 |
| DE69007456D1 (de) | 1994-04-21 |
| US5232782A (en) | 1993-08-03 |
| DE69007456T2 (de) | 1994-10-20 |
| CA2033145A1 (fr) | 1991-06-28 |
| PT96327A (pt) | 1991-09-30 |
| FR2656318A1 (fr) | 1991-06-28 |
| JPH0737572B2 (ja) | 1995-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |