ATE102827T1 - Phenolische thioaether, sulfoxide und disulfide als hemmstoffe der 5-lipoxigenase. - Google Patents

Phenolische thioaether, sulfoxide und disulfide als hemmstoffe der 5-lipoxigenase.

Info

Publication number
ATE102827T1
ATE102827T1 AT88108874T AT88108874T ATE102827T1 AT E102827 T1 ATE102827 T1 AT E102827T1 AT 88108874 T AT88108874 T AT 88108874T AT 88108874 T AT88108874 T AT 88108874T AT E102827 T1 ATE102827 T1 AT E102827T1
Authority
AT
Austria
Prior art keywords
sulfoxides
thioaethers
disulphides
phenolic
lipoxigenase inhibitors
Prior art date
Application number
AT88108874T
Other languages
English (en)
Inventor
Richard August Mueller
Richard Allen Partis
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE102827T1 publication Critical patent/ATE102827T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
AT88108874T 1987-06-05 1988-06-03 Phenolische thioaether, sulfoxide und disulfide als hemmstoffe der 5-lipoxigenase. ATE102827T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5845787A 1987-06-05 1987-06-05
EP88108874A EP0293900B1 (de) 1987-06-05 1988-06-03 Phenolische Thioäther, Sulfoxide und Disulfide als Hemmstoffe der 5-Lipoxigenase

Publications (1)

Publication Number Publication Date
ATE102827T1 true ATE102827T1 (de) 1994-04-15

Family

ID=22016921

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88108874T ATE102827T1 (de) 1987-06-05 1988-06-03 Phenolische thioaether, sulfoxide und disulfide als hemmstoffe der 5-lipoxigenase.

Country Status (6)

Country Link
EP (1) EP0293900B1 (de)
JP (1) JPS63310821A (de)
AT (1) ATE102827T1 (de)
CA (1) CA1327050C (de)
DE (1) DE3888394T2 (de)
ES (1) ES2061561T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2754039B2 (ja) * 1988-06-24 1998-05-20 塩野義製薬株式会社 ジ―ｔｅｒｔ―ブチルヒドロキシフェニルチオ誘導体
US5147893A (en) * 1991-05-09 1992-09-15 G. D. Searle & Co. Cyclic phenolic thioethers
US5250567A (en) * 1991-05-09 1993-10-05 G. D. Searle & Co. Cyclic phenolic thioethers
US5272178A (en) * 1991-11-18 1993-12-21 G. D. Searle & Co. Compounds of cyclic phenolic thioethers which are useful in stimulating and inhibiting superoxide generation
US5420343A (en) * 1994-08-31 1995-05-30 G. D. Searle & Co. Derivatives of aromatic cyclic alkylethers
CN106939075B (zh) 2015-12-31 2019-09-17 银谷制药有限责任公司 一种亲水性聚酯及其嵌段共聚物
CN108299263B (zh) * 2018-01-30 2020-12-01 北京德默高科医药技术有限公司 一种普罗布考衍生物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
AU584669B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
CA1332057C (en) * 1985-02-04 1994-09-20 Richard August Mueller Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides
US4663333A (en) * 1985-02-04 1987-05-05 G. D. Searle & Co. Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions
CA1316932C (en) * 1985-05-20 1993-04-27 Richard A. Mueller Methods and compositions for inhibiting lipoxygenase
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
EP0293900A3 (de) 1991-01-30
EP0293900A2 (de) 1988-12-07
JPS63310821A (ja) 1988-12-19
DE3888394D1 (de) 1994-04-21
DE3888394T2 (de) 1994-07-28
ES2061561T3 (es) 1994-12-16
EP0293900B1 (de) 1994-03-16
CA1327050C (en) 1994-02-15

Similar Documents

Publication Publication Date Title
DK50487D0 (da) Phenoliske thioethere og farmaceutisk acceptable salte deraf samt dens anvendelse som lipoxygenaseinhibitorer
IS2241B (is) Píperasín afleiður og notkun þeirra sem bólgueyðandi miðlar
SE7903186L (sv) Cerebralverksamt medel
DE3882572D1 (de) Terpen-derivate von 2,5-dimercapto-1,3,4-thiadiazolen und diese enthaltende schmiermittel.
ATE138060T1 (de) N-substituierte thioakylphenothiazine
GR1000118B (el) Συνθεσις 1,2-διοξετανων & ενδιαμεσαι ουσιαι δι αυτην.
DK157787D0 (da) Zwitterioniske, bicykliske forbindelser og deres salte, solvater, hydrater og estere
ATE102827T1 (de) Phenolische thioaether, sulfoxide und disulfide als hemmstoffe der 5-lipoxigenase.
DE3067072D1 (en) Novel substituted arylene compounds and processes for their production
ES2059438T3 (es) Tioalquilamidas fenolicas inhibidoras de 5-lipoxigenasa.
ATE58900T1 (de) Diaryldiazolylmethane.
FI891986A0 (fi) Farmaceutiska sammansaettningar foer behandling av psoriasis.
PT796618E (pt) Tratamento e profilaxia da pancreatite
ES450601A1 (es) Un procedimiento para la preparacion de nuevos derivados de 4,5-diaril-2-(tiosustituido) michazol.
ATE17480T1 (de) Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene.
ES2099865T3 (es) Ciclopentanoperhidrofenantreno-17beta-(3-furil)-3-derivados y composiciones farmaceuticas que comprenden los mismos para el tratamiento de trastornos cardiovasculares.
IL70128A0 (en) Polyene compounds,their manufacture and pharmaceutical compositions containing them
DE3571976D1 (de) Pyrazole compounds
DE3582935D1 (de) Mittel zur behandlung von erkrankungen der venen und des analbereichs.
DE3576689D1 (de) Oxa- und thiadiazolylderivate und ihre verwendung.
FI844645L (fi) 1,7-difenyl-3-metylaza-7-cyan-8 -metyl-nonan foer anvaendning vid bekaempning av sjukdomar.
ATE86983T1 (de) Acyl-derivate von hydroxy-pyrimidinen.
DE59403835D1 (de) Oxidation von Polyarylensulfiden
ES2061775T3 (es) Derivados de estrobirulina, su obtencion y empleo.
DE3853126D1 (de) Derivate der fluorierten Arachidonsäure.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee