ES2099865T3 - Ciclopentanoperhidrofenantreno-17beta-(3-furil)-3-derivados y composiciones farmaceuticas que comprenden los mismos para el tratamiento de trastornos cardiovasculares. - Google Patents

Ciclopentanoperhidrofenantreno-17beta-(3-furil)-3-derivados y composiciones farmaceuticas que comprenden los mismos para el tratamiento de trastornos cardiovasculares.

Info

Publication number
ES2099865T3
ES2099865T3 ES93109612T ES93109612T ES2099865T3 ES 2099865 T3 ES2099865 T3 ES 2099865T3 ES 93109612 T ES93109612 T ES 93109612T ES 93109612 T ES93109612 T ES 93109612T ES 2099865 T3 ES2099865 T3 ES 2099865T3
Authority
ES
Spain
Prior art keywords
derivatives
treatment
pharmaceutical compositions
ciclopentanoperhidrofenantreno
furil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93109612T
Other languages
English (en)
Inventor
Luisa Quadri
Luigi Bernardi
Patrizia Ferrari
Mauro Gobbini
Piero Melloni
Loredana Valentino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2099865T3 publication Critical patent/ES2099865T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0021—Oxiranes at position 14(15)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN CICLOPENTANPERHIDROFENANTREN-17(BETA)-(3-FURIL)-DERIVADOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES TALES COMO LOS COLAPSOS Y LA HIPERTENSION.
ES93109612T 1992-07-01 1993-06-16 Ciclopentanoperhidrofenantreno-17beta-(3-furil)-3-derivados y composiciones farmaceuticas que comprenden los mismos para el tratamiento de trastornos cardiovasculares. Expired - Lifetime ES2099865T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4221636A DE4221636C1 (de) 1992-07-01 1992-07-01 Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Publications (1)

Publication Number Publication Date
ES2099865T3 true ES2099865T3 (es) 1997-06-01

Family

ID=6462265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93109612T Expired - Lifetime ES2099865T3 (es) 1992-07-01 1993-06-16 Ciclopentanoperhidrofenantreno-17beta-(3-furil)-3-derivados y composiciones farmaceuticas que comprenden los mismos para el tratamiento de trastornos cardiovasculares.

Country Status (8)

Country Link
US (2) US5432169A (es)
EP (1) EP0576915B1 (es)
JP (1) JPH0665284A (es)
AT (1) ATE151774T1 (es)
DE (2) DE4221636C1 (es)
DK (1) DK0576915T3 (es)
ES (1) ES2099865T3 (es)
GR (1) GR3023310T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate
DE4227616C2 (de) * 1992-08-20 1995-04-13 Sigma Tau Ind Farmaceuti 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
FI961792A0 (fi) * 1993-10-27 1996-04-26 Merrell Pharma Inc Steroidi-C17-20-lyaasiestäjinä käyttökelpoiset delta16-tyydyttymättömät heterosykliset C17-steroidit
IT1282286B1 (it) * 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
JP3875125B2 (ja) * 2001-04-11 2007-01-31 シャープ株式会社 液晶表示装置
US20040064050A1 (en) * 2002-09-20 2004-04-01 Jun Liu System and method for screening tissue
WO2007060206A2 (en) * 2005-11-25 2007-05-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Further crystalline forms of rostafuroxin
DK3599243T3 (da) * 2018-07-26 2023-07-10 Cvie Therapeutics Ltd 17beta-heterocyklyl-digitalis-lignende forbindelser til behandlingen af hjertesvigt
DK3805243T3 (da) 2019-10-09 2024-01-02 Windtree Therapeutics Inc Androstanderivater med aktivitet som rene eller hovedsageligt rene stimulatorer af serca2a til behandling af hjertesvigt

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1227015B (de) * 1963-01-23 1966-10-20 Bayer Ag Verfahren zur Herstellung von 3beta-Hydroxy-(bzw.-Acyloxy)-steroid-20-amidylhydrazonen der Pregnanreihe
GB1081647A (en) * 1965-04-01 1967-08-31 Shionogi & Co Furan compounds
US3436390A (en) * 1966-05-24 1969-04-01 American Home Prod 4,4-dihydroxy-2-butenoic acid lactones
DE1807585C3 (de) * 1968-11-04 1974-11-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen 14,15beta-Epoxycardenolide, Verfahren zu deren Herstellung und diese enthaltende Mittel
DE1812946C3 (de) * 1968-12-05 1978-11-02 Hoechst Ag, 6000 Frankfurt Herzwirksame 14beta, lSbeta Oxidobutatrienolide und Verfahren zu ihrer Herstellung
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
GB8916636D0 (en) * 1989-07-20 1989-09-06 Erba Carlo Spa Steroid ethers
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
HK1005877A1 (en) 1999-01-29
DE69309790D1 (de) 1997-05-22
US5593982A (en) 1997-01-14
DE69309790T2 (de) 1997-09-11
DK0576915T3 (da) 1997-09-01
EP0576915A2 (en) 1994-01-05
GR3023310T3 (en) 1997-08-29
DE4221636C1 (de) 1994-03-31
ATE151774T1 (de) 1997-05-15
EP0576915A3 (en) 1994-07-06
US5432169A (en) 1995-07-11
JPH0665284A (ja) 1994-03-08
EP0576915B1 (en) 1997-04-16

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