ATE102997T1 - Thymosin und tnf-kodierende dna. - Google Patents

Thymosin und tnf-kodierende dna.

Info

Publication number: ATE102997T1
Authority: AT; Austria
Prior art keywords: val; ser; arg; pro; thr
Prior art date: 1988-04-03

Application number

AT89400912T

Other languages

English (en)

Inventor

Den Ichi Mizuno

Gen-Ichiro Soma

Yoshiaki Biotechnology R Tsuji

Sun Sawa-Arashi University

Original Assignee

Den Ichi Mizuno

Soma Genichiro

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-03

Filing date

1989-04-03

Publication date

1994-04-15

1989-04-03 Application filed by Den Ichi Mizuno, Soma Genichiro filed Critical Den Ichi Mizuno

1994-04-15 Application granted granted Critical

1994-04-15 Publication of ATE102997T1 publication Critical patent/ATE102997T1/de

Links

102000007501 Thymosin Human genes 0.000 title 1
108010046075 Thymosin Proteins 0.000 title 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 title 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 4
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Plant Pathology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT89400912T 1988-04-03 1989-04-03 Thymosin und tnf-kodierende dna. ATE102997T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP63081683A JP2828988B2 (ja)	1988-04-03	1988-04-03	新規ｄｎａとその生産方法、それを有する新規プラスミド、新規ポリペプチドとその生産方法、及び該ポリペプチドからなる新規抗腫瘍剤
EP89400912A EP0341100B1 (de)	1988-04-03	1989-04-03	Thymosin und TNF-kodierende DNA

Publications (1)

Publication Number	Publication Date
ATE102997T1 true ATE102997T1 (de)	1994-04-15

Family

ID=13753155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89400912T ATE102997T1 (de)	1988-04-03	1989-04-03	Thymosin und tnf-kodierende dna.

Country Status (5)

Country	Link
EP (1)	EP0341100B1 (de)
JP (1)	JP2828988B2 (de)
AT (1)	ATE102997T1 (de)
CA (1)	CA1340244C (de)
DE (1)	DE68913802T2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH02101019A (ja) *	1988-10-05	1990-04-12	Genichiro Soma	抗エイズ剤
US5795859A (en) *	1991-07-05	1998-08-18	Peptide Technology Limited	Peptide which abrogates TNF and/or LPS toxicity
RU2225443C1 (ru) *	2002-07-25	2004-03-10	Общество с ограниченной ответственностью "Научно-производственное предприятие "Фармаклон"	РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СИНТЕЗ, СПОСОБ ПОЛУЧЕНИЯ И ПРЕПАРАТ РЕКОМБИНАНТНОГО ГИБРИДНОГО БЕЛКА α-ФАКТОР НЕКРОЗА ОПУХОЛЕЙ-ТИМОЗИН-α1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3582183D1 (de) *	1984-03-06	1991-04-25	Dainippon Pharmaceutical Co	Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US5081021A (en) *	1986-02-04	1992-01-14	Mizuno Den Ichi	DNA encoding HTNF variants exhibiting enhanced activity

1988
- 1988-04-03 JP JP63081683A patent/JP2828988B2/ja not_active Expired - Fee Related
1989
- 1989-04-03 DE DE68913802T patent/DE68913802T2/de not_active Expired - Fee Related
- 1989-04-03 CA CA000595536A patent/CA1340244C/en not_active Expired - Fee Related
- 1989-04-03 EP EP89400912A patent/EP0341100B1/de not_active Expired - Lifetime
- 1989-04-03 AT AT89400912T patent/ATE102997T1/de active

Also Published As

Publication number	Publication date
EP0341100A3 (en)	1990-09-12
CA1340244C (en)	1998-12-15
DE68913802D1 (de)	1994-04-21
EP0341100A2 (de)	1989-11-08
JPH01256390A (ja)	1989-10-12
EP0341100B1 (de)	1994-03-16
DE68913802T2 (de)	1994-10-13
JP2828988B2 (ja)	1998-11-25

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