ATE103594T1 - Fucosidase-inhibitoren. - Google Patents
Fucosidase-inhibitoren.Info
- Publication number
- ATE103594T1 ATE103594T1 AT90870105T AT90870105T ATE103594T1 AT E103594 T1 ATE103594 T1 AT E103594T1 AT 90870105 T AT90870105 T AT 90870105T AT 90870105 T AT90870105 T AT 90870105T AT E103594 T1 ATE103594 T1 AT E103594T1
- Authority
- AT
- Austria
- Prior art keywords
- fucosidase inhibitors
- inhibitors
- beta
- fucosidase
- homofuconojirimycin
- Prior art date
Links
- 102000012086 alpha-L-Fucosidase Human genes 0.000 title abstract 2
- 108010061314 alpha-L-Fucosidase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- DCVWZPYTNWZZIM-UHFFFAOYSA-N alpha-7-deoxyhomonojirimycin Natural products CC1NC(CO)C(O)CC1O DCVWZPYTNWZZIM-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/371,943 US5100797A (en) | 1989-06-27 | 1989-06-27 | Fucosidase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE103594T1 true ATE103594T1 (de) | 1994-04-15 |
Family
ID=23466049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90870105T ATE103594T1 (de) | 1989-06-27 | 1990-06-26 | Fucosidase-inhibitoren. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5100797A (de) |
| EP (1) | EP0406211B1 (de) |
| JP (1) | JP2927893B2 (de) |
| AT (1) | ATE103594T1 (de) |
| CA (1) | CA2019798C (de) |
| DE (1) | DE69007695T2 (de) |
| DK (1) | DK0406211T3 (de) |
| ES (1) | ES2063329T3 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276120A (en) * | 1991-05-30 | 1994-01-04 | The Scripps Research Institute | Process for forming omega-deuxy-azasugars |
| WO1992021657A1 (en) * | 1991-05-30 | 1992-12-10 | The Scripps Research Institute | Omega-deoxy-azasugars |
| KR100692957B1 (ko) * | 1999-02-02 | 2007-03-12 | 자이단 호진 비세부츠 가가쿠 겐쿠 카이 | 2-ｎ-치환 또는 비치환-2-아미노-5-메틸피페리딘-3,4-디올과 그의 제조방법 |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| ES2302697T3 (es) | 1999-08-10 | 2008-08-01 | The Chancellor, Masters And Scholars Of The University Of Oxford | Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales. |
| US20080138351A1 (en) * | 2006-08-02 | 2008-06-12 | United Therapeutics Corporation | Liposome treatment of viral infections |
| JP2010510171A (ja) * | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| CN102427804A (zh) * | 2009-03-27 | 2012-04-25 | 牛津大学之校长及学者 | 降低胆固醇水平的脂质体 |
| AU2011210756B2 (en) * | 2010-01-28 | 2016-11-03 | Horizon Orphan Llc | Method For Treating Liver Disorders With Receptor Associated Protein (RAP) Peptide-Fucosidase Inhibitor Conjugates |
| EP3328832B1 (de) | 2015-07-30 | 2021-03-03 | Horizon Orphan LLC | Fucosidase-inhibitoren |
| CN112843081B (zh) * | 2021-02-02 | 2022-07-05 | 四川大学 | 一种dna四面体-白藜芦醇复合物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2848117A1 (de) * | 1978-11-06 | 1980-05-14 | Bayer Ag | Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels |
| DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
| US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
| US4861892A (en) * | 1988-02-12 | 1989-08-29 | G. D. Searle & Co. | Method for synthesis of deoxymannojirimycin |
| US4992460A (en) * | 1989-09-08 | 1991-02-12 | Monsanto Company | Bicyclic tetrahydroxylated pyrrolizidines |
| US4996329A (en) * | 1989-10-20 | 1991-02-26 | Monsanto Company | Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process for their preparation |
-
1989
- 1989-06-27 US US07/371,943 patent/US5100797A/en not_active Expired - Lifetime
-
1990
- 1990-06-26 DK DK90870105.5T patent/DK0406211T3/da active
- 1990-06-26 AT AT90870105T patent/ATE103594T1/de not_active IP Right Cessation
- 1990-06-26 JP JP2165886A patent/JP2927893B2/ja not_active Expired - Fee Related
- 1990-06-26 CA CA002019798A patent/CA2019798C/en not_active Expired - Fee Related
- 1990-06-26 DE DE69007695T patent/DE69007695T2/de not_active Expired - Fee Related
- 1990-06-26 EP EP90870105A patent/EP0406211B1/de not_active Expired - Lifetime
- 1990-06-26 ES ES90870105T patent/ES2063329T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0406211A3 (en) | 1991-05-08 |
| JP2927893B2 (ja) | 1999-07-28 |
| DE69007695D1 (de) | 1994-05-05 |
| DK0406211T3 (da) | 1994-05-02 |
| EP0406211A2 (de) | 1991-01-02 |
| DE69007695T2 (de) | 1994-08-11 |
| US5100797A (en) | 1992-03-31 |
| EP0406211B1 (de) | 1994-03-30 |
| JPH0331260A (ja) | 1991-02-12 |
| CA2019798A1 (en) | 1990-12-27 |
| CA2019798C (en) | 2001-03-20 |
| ES2063329T3 (es) | 1995-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |