ATE104292T1 - Verbindungen fuer die induktion der in vitround in vivo-erzeugung von cytokinen. - Google Patents

Verbindungen fuer die induktion der in vitround in vivo-erzeugung von cytokinen.

Info

Publication number: ATE104292T1
Authority: AT; Austria
Prior art keywords: carbons; carbon atoms; compounds; halogen; alkyl
Prior art date: 1987-10-09

Application number

AT88116788T

Other languages

English (en)

Inventor

Michael Albeck

Benjamin Sredni

Original Assignee

Michael Albeck

Benjamin Sredni

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-09

Filing date

1988-10-10

Publication date

1994-04-15

1988-10-10 Application filed by Michael Albeck, Benjamin Sredni filed Critical Michael Albeck

1994-04-15 Application granted granted Critical

1994-04-15 Publication of ATE104292T1 publication Critical patent/ATE104292T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 5
102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
238000000338 in vitro Methods 0.000 title 1
230000001939 inductive effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
OFDISMSWWNOGFW-UHFFFAOYSA-N 1-(4-ethoxy-3-fluorophenyl)ethanamine Chemical compound CCOC1=CC=C(C(C)N)C=C1F OFDISMSWWNOGFW-UHFFFAOYSA-N 0.000 abstract 1
208000030507 AIDS Diseases 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005093 alkyl carbonyl alkyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
-1 ammonium halide Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052711 selenium Inorganic materials 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
229910052714 tellurium Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D329/00—Heterocyclic compounds containing rings having oxygen and selenium or oxygen and tellurium atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
- C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
- C07D517/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88116788T 1987-10-09 1988-10-10 Verbindungen fuer die induktion der in vitround in vivo-erzeugung von cytokinen. ATE104292T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/107,131 US4962207A (en)	1985-09-30	1987-10-09	Organic derivatives of tellurium and selenium
EP88116788A EP0311138B1 (de)	1987-10-09	1988-10-10	Verbindungen für die Induktion der in vitro- und in vivo-Erzeugung von Cytokinen

Publications (1)

Publication Number	Publication Date
ATE104292T1 true ATE104292T1 (de)	1994-04-15

Family

ID=22315021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88116788T ATE104292T1 (de)	1987-10-09	1988-10-10	Verbindungen fuer die induktion der in vitround in vivo-erzeugung von cytokinen.

Country Status (6)

Country	Link
US (1)	US4962207A (de)
EP (1)	EP0311138B1 (de)
JP (1)	JP2749596B2 (de)
AT (1)	ATE104292T1 (de)
DE (1)	DE3889057T2 (de)
ES (1)	ES2051814T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4946437A (en) *	1988-12-02	1990-08-07	Bar-Ilan University	Method for the stimulation of bone marrow cells
DE69534535T2 (de) *	1994-12-15	2006-07-06	Baker Norton Pharmaceuticals, Inc., Miami	Verfahren und mittel zur verminderung der tumorentwicklung mittels einer kombination aus einer taxanverbindung und einer tellur und/oder selenverbindung
US6482311B1 (en) *	2000-08-01	2002-11-19	Tda Research, Inc.	Methods for suppression of filamentous coke formation
US7045150B2 (en) *	2001-07-31	2006-05-16	Tellus Biotech Ltd.	Tellurium containing nutrient formulation and process for enhancing the cumulative weight gain or feed efficacy in poultry
AU2004304716B2 (en) *	2003-12-18	2010-05-27	Biomas Ltd.	Tellurium derivatives for prevention and treatment of neurodegenerative processes
DK1715785T3 (da) *	2004-01-22	2014-06-30	Biomas Ltd	Terapeutiske fremgangsmåder og farmaceutiske sammensætninger tilbehandling af vorter med tellurforbindelser
EP1791535B1 (de)	2004-09-17	2008-07-30	BioMAS Ltd.	Neue tellurium-verbindungen und ihre verwendung als immunmodulatoren
CA2580805A1 (en) *	2004-09-17	2006-03-23	Biomas Ltd.	Use of tellurium compounds as adjuvants
WO2007032009A2 (en) *	2005-09-15	2007-03-22	Biomas Ltd.	Use of tellurium compounds for treatment of basal cell carcinoma and/or actinic keratosis
WO2009066300A2 (en) *	2007-11-23	2009-05-28	Biomas Ltd.	Methods and compositions for inhibiting integrins using tellurium-containing compounds
WO2010146585A1 (en)	2009-06-16	2010-12-23	Biomas Ltd.	Tellurium-containing compounds for treating viral infections
US11304976B2 (en)	2015-02-18	2022-04-19	Enlivex Therapeutics Ltd	Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en)	2015-02-18	2022-05-03	Enlivex Therapeutics Ltd	Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en)	2015-02-18	2022-11-15	Enlivex Therapeutics R&D Ltd	Combination immune therapy and cytokine control therapy for cancer treatment
CN109069539A (zh)	2016-02-18	2018-12-21	恩立夫克治疗有限责任公司	用于癌症治疗的联合免疫疗法和细胞因子控制疗法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4239846A (en) *	1978-04-10	1980-12-16	Eastman Kodak Company	Tellurium (IV) compounds and compositions
US4508662A (en) *	1983-03-24	1985-04-02	The United States Of America As Represented By The Secretary Of The Air Force	Pentafluorotelluriumoxide fluorocarbons
US4761490A (en) *	1985-03-15	1988-08-02	Bar-Ilan University	Organic derivatives of tellurium and selenium and their use to stimulate cytokine production

1987
- 1987-10-09 US US07/107,131 patent/US4962207A/en not_active Expired - Lifetime
1988
- 1988-10-10 DE DE3889057T patent/DE3889057T2/de not_active Expired - Fee Related
- 1988-10-10 AT AT88116788T patent/ATE104292T1/de not_active IP Right Cessation
- 1988-10-10 ES ES88116788T patent/ES2051814T3/es not_active Expired - Lifetime
- 1988-10-10 EP EP88116788A patent/EP0311138B1/de not_active Expired - Lifetime
- 1988-10-11 JP JP63255760A patent/JP2749596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2051814T3 (es)	1994-07-01
EP0311138A2 (de)	1989-04-12
DE3889057D1 (de)	1994-05-19
EP0311138A3 (en)	1990-07-18
JPH01238580A (ja)	1989-09-22
JP2749596B2 (ja)	1998-05-13
DE3889057T2 (de)	1994-08-11
EP0311138B1 (de)	1994-04-13
US4962207A (en)	1990-10-09

Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
2003-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE104292T1 (de)	1994-04-15	Verbindungen fuer die induktion der in vitround in vivo-erzeugung von cytokinen.
RU92004336A (ru)	1995-08-20	Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
DE3272792D1 (en)	1986-10-02	Process for the preparation of 2-penem compounds
PL317726A1 (en)	1997-04-28	Novel compounds, methods of obtaining them and antineoplastic agents
TW429255B (en)	2001-04-11	Pyrazine compounds having treatment of central nervous system diseases and disorders
IL69882A (en)	1986-11-30	Analgesia-effecting 5-hydroxytryptophan derivatives and pharmaceutical compositions comprising them
PT83845B (en)	1989-01-03	Process for preparing antihypertensive pharmaceutical combination products containing a dihydropyridine and a pyridazodiazepine
ATE37533T1 (de)	1988-10-15	Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten.
HUT39448A (en)	1986-09-29	Process for producing 1,6-naphtiridine derivatives and pharmaceutical compositions containing them
DE3174132D1 (en)	1986-04-24	New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof
ES8407059A1 (es)	1984-09-01	Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado
IL85253A0 (en)	1988-07-31	Ergoline derivatives,their preparation and pharmaceutical compositions containing them
SE8901060D0 (sv)	1989-03-28	New compounds
DE3267291D1 (en)	1985-12-12	Heteroarylpropanol amines, process for preparing them and medicines containing these compounds
HUT34478A (en)	1985-03-28	Process for producing hexahydro-pyrrolo/2.1-a/isoquinoline derivatives and pharmaceutical compositions containing them
GB1032377A (en)	1966-06-08	Asymmetrical pyridoxolyl disulphides and their preparation
HUT53638A (en)	1990-11-28	Process for producing 15-amino-substituted 20,21-dinoreburnamenie derivatives and pharmaceutical compositions containing them
ES8505656A1 (es)	1985-06-01	Procedimiento para la preparacion de quinolinonas-4
ZA826183B (en)	1984-04-25	Derivatives of propan-2-ols,process for preparing these compounds,and pharmaceutical compositions thereof