ATE104297T1 - Verfahren zur herstellung von kondensierten pyridinverbindungen. - Google Patents

Verfahren zur herstellung von kondensierten pyridinverbindungen.

Info

Publication number
ATE104297T1
ATE104297T1 AT87308921T AT87308921T ATE104297T1 AT E104297 T1 ATE104297 T1 AT E104297T1 AT 87308921 T AT87308921 T AT 87308921T AT 87308921 T AT87308921 T AT 87308921T AT E104297 T1 ATE104297 T1 AT E104297T1
Authority
AT
Austria
Prior art keywords
preparation
hydroxy
amino
pyridine compounds
carboxyphenyl
Prior art date
Application number
AT87308921T
Other languages
English (en)
Inventor
Edward C Taylor
George S K Wong
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Application granted granted Critical
Publication of ATE104297T1 publication Critical patent/ATE104297T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT87308921T 1986-10-20 1987-10-08 Verfahren zur herstellung von kondensierten pyridinverbindungen. ATE104297T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/922,511 US4818819A (en) 1986-10-20 1986-10-20 Process for the preparation of fused pyridine compounds
EP87308921A EP0265126B1 (de) 1986-10-20 1987-10-08 Verfahren zur Herstellung von kondensierten Pyridinverbindungen

Publications (1)

Publication Number Publication Date
ATE104297T1 true ATE104297T1 (de) 1994-04-15

Family

ID=25447136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87308921T ATE104297T1 (de) 1986-10-20 1987-10-08 Verfahren zur herstellung von kondensierten pyridinverbindungen.

Country Status (7)

Country Link
US (1) US4818819A (de)
EP (1) EP0265126B1 (de)
JP (2) JPH07103120B2 (de)
AT (1) ATE104297T1 (de)
CA (1) CA1301157C (de)
DE (1) DE3789599T2 (de)
ES (1) ES2062985T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US5008391A (en) * 1989-07-07 1991-04-16 Eli Lilly And Company Enantioselective synthesis of antifolates
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
DE69618875D1 (de) * 1995-09-08 2002-03-14 Univ Princeton Nicht-klassische Antifolate
WO2003033477A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor
EP1434585A1 (de) 2001-10-12 2004-07-07 Warner-Lambert Company LLC Alkine als inhibitoren von metalloproteinasen
WO2004007469A1 (en) * 2002-07-12 2004-01-22 Warner-Lambert Company Llc New alkynylated quinazolin compounds as mmp-13 inhibitors
US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
WO2003033478A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkynylated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitors
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) * 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) * 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
MXPA05000638A (es) * 2002-07-17 2005-03-31 Warner Lambert Co Combinacion de un inhibidor alquino alosterico de metaloproteinasa-13 de matriz con un inhibidor selectivo de ciclooxigenasa-2 que no es celecoxib o valdecoxib.
BR0312708A (pt) * 2002-07-17 2005-04-26 Warner Lambert Co Combinação de um inibidor alcina alostérico de metaloproteinase-13 de matriz com celecoxib ou valdecoxib
WO2005016926A1 (en) * 2003-08-19 2005-02-24 Warner-Lambert Company Llc Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
GB0428475D0 (en) * 2004-12-30 2005-02-02 4 Aza Bioscience Nv Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
GB0503506D0 (en) * 2005-02-21 2005-03-30 4 Aza Bioscience Nv Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
AU2006261607A1 (en) * 2005-06-24 2006-12-28 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis C.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
TW200840584A (en) * 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
CA1085729A (en) * 1976-03-05 1980-09-16 Joseph I. De Graw Process and composition for treatment of leukemia and other tumors
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4172200A (en) * 1978-06-15 1979-10-23 Southern Research Institute Process for the preparation of 10-deazaaminopterin and related compounds
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
EP0166726B1 (de) * 1983-12-27 1988-11-17 Sri International 10-ethyl-8,10-dideazaminopterine
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives

Also Published As

Publication number Publication date
DE3789599D1 (de) 1994-05-19
JPH08119968A (ja) 1996-05-14
JPH07103120B2 (ja) 1995-11-08
EP0265126A2 (de) 1988-04-27
JP2558086B2 (ja) 1996-11-27
JPS63183580A (ja) 1988-07-28
DE3789599T2 (de) 1994-07-21
US4818819A (en) 1989-04-04
EP0265126B1 (de) 1994-04-13
EP0265126A3 (en) 1989-08-30
ES2062985T3 (es) 1995-01-01
CA1301157C (en) 1992-05-19

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Legal Events

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