ATE105283T1 - Synthese von mannojirimycin-derivaten. - Google Patents

Synthese von mannojirimycin-derivaten.

Info

Publication number: ATE105283T1
Authority: AT; Austria
Prior art keywords: homomannojirimycin; mannojirimycin; synthesis; derivatives; epi
Prior art date: 1989-10-11

Application number

AT9090870141T

Other languages

English (en)

Inventor

George William John Fleet

Of Oxford University

Ian Bruce

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-11

Filing date

1990-09-04

Publication date

1994-05-15

1990-09-04 Application filed by Monsanto Co filed Critical Monsanto Co

1994-05-15 Application granted granted Critical

1994-05-15 Publication of ATE105283T1 publication Critical patent/ATE105283T1/de

Links

BGMYHTUCJVZIRP-QTVWNMPRSA-N (3s,4s,5r,6r)-6-(hydroxymethyl)piperidine-2,3,4,5-tetrol Chemical class OC[C@H]1NC(O)[C@@H](O)[C@@H](O)[C@@H]1O BGMYHTUCJVZIRP-QTVWNMPRSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
CLVUFWXGNIFGNC-KVTDHHQDSA-N (2r,3r,5r,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol Chemical compound OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O CLVUFWXGNIFGNC-KVTDHHQDSA-N 0.000 abstract 3
CLVUFWXGNIFGNC-UHFFFAOYSA-N alpha-homonojirimycin Natural products OCC1NC(CO)C(O)C(O)C1O CLVUFWXGNIFGNC-UHFFFAOYSA-N 0.000 abstract 2
BUBVLQDEIIUIQG-UHFFFAOYSA-N 3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-one Chemical compound C=1C=CC=CC=1COC1C(OCC=2C=CC=CC=2)C(OCC=2C=CC=CC=2)C(=O)OC1COCC1=CC=CC=C1 BUBVLQDEIIUIQG-UHFFFAOYSA-N 0.000 abstract 1
QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002009 diols Chemical class 0.000 abstract 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
230000014759 maintenance of location Effects 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
239000003223 protective agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT9090870141T 1989-10-11 1990-09-04 Synthese von mannojirimycin-derivaten. ATE105283T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/419,806 US5011929A (en)	1989-05-15	1989-10-11	Synthesis of mannojirimycin derivatives

Publications (1)

Publication Number	Publication Date
ATE105283T1 true ATE105283T1 (de)	1994-05-15

Family

ID=23663839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT9090870141T ATE105283T1 (de)	1989-10-11	1990-09-04	Synthese von mannojirimycin-derivaten.

Country Status (8)

Country	Link
US (1)	US5011929A (de)
EP (1)	EP0427694B1 (de)
JP (1)	JP2942606B2 (de)
AT (1)	ATE105283T1 (de)
CA (1)	CA2024843C (de)
DE (1)	DE69008668T2 (de)
DK (1)	DK0427694T3 (de)
ES (1)	ES2054327T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5210089A (en) *	1992-02-04	1993-05-11	Monsanto Company	D-rhamnono-1,5-lactone
US5250703A (en) *	1992-09-29	1993-10-05	Monsanto Company	Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
DE60037664T2 (de)	1999-08-10	2008-12-24	The Chancellor, Masters And Scholars Of The University Of Oxford	Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel
US7256005B2 (en)	1999-08-10	2007-08-14	The Chancellor, Masters And Scholars Of The University Of Oxford	Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
KR100665194B1 (ko) *	2005-08-30	2007-01-04	주식회사 한림전자	전자부품 솔더용 고정홀더
CN102727437A (zh)	2006-08-02	2012-10-17	牛津大学院长校长专家委员会	病毒感染的脂质体治疗
CA2666814A1 (en) *	2006-08-21	2008-05-29	United Therapeutics Corporation	Combination therapy for treatment of viral infections
KR20100127842A (ko) *	2008-03-26	2010-12-06	유니버시티 오브 옥스퍼드	소포체 표적화 리포좀
EP2410989A2 (de) *	2009-03-27	2012-02-01	The Chancellor, Masters and Scholars of the University of Oxford	Liposome zur senkung des cholesterinspiegels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3024901A1 (de) *	1980-07-01	1982-01-28	Bayer Ag, 5090 Leverkusen	Herbizide mittel auf basis von piperidin-derivaten
US4357360A (en) *	1980-11-13	1982-11-02	International Flavors & Fragrances Inc.	Use of tricyclic alcohols, ethers and esters for augmenting or enhancing the aroma or taste of foodstuffs
DE3737523A1 (de) *	1987-11-05	1989-05-18	Bayer Ag	Verwendung von substituierten hydroxypiperidinen als antivirale mittel

1989
- 1989-10-11 US US07/419,806 patent/US5011929A/en not_active Expired - Lifetime
1990
- 1990-09-04 AT AT9090870141T patent/ATE105283T1/de not_active IP Right Cessation
- 1990-09-04 DE DE69008668T patent/DE69008668T2/de not_active Expired - Fee Related
- 1990-09-04 EP EP90870141A patent/EP0427694B1/de not_active Expired - Lifetime
- 1990-09-04 DK DK90870141.0T patent/DK0427694T3/da active
- 1990-09-04 ES ES90870141T patent/ES2054327T3/es not_active Expired - Lifetime
- 1990-09-07 JP JP2238863A patent/JP2942606B2/ja not_active Expired - Fee Related
- 1990-09-07 CA CA002024843A patent/CA2024843C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2942606B2 (ja)	1999-08-30
DE69008668T2 (de)	1994-11-24
JPH03127775A (ja)	1991-05-30
DE69008668D1 (de)	1994-06-09
DK0427694T3 (da)	1994-06-13
EP0427694B1 (de)	1994-05-04
US5011929A (en)	1991-04-30
CA2024843A1 (en)	1991-04-12
EP0427694A1 (de)	1991-05-15
ES2054327T3 (es)	1994-08-01
CA2024843C (en)	2001-11-20

Similar Documents

Publication	Publication Date	Title
IL89921A0 (en)	1989-12-15	1,3-dioxolane derivatives and pharmaceutical compositions containing the same
DE69010139D1 (de)	1994-07-28	Haarkräftigungsmittel.
FI891176A0 (fi)	1989-03-13	Peptidfoereningar, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
NZ240230A (en)	1993-01-27	Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
ES2077138T3 (es)	1995-11-16	Derivados de aminocumarano, su produccion y su uso.
ES2091212T3 (es)	1996-11-01	Compuestos de xantina.
FI855117A0 (fi)	1985-12-20	Segmenttipolyestereitä ja niiden kaltaisia yhdisteitä käytettäviksi lianirrotusaineina pesuainekoostumuksissa
NO302755B1 (no)	1998-04-20	Morfinan-derivater
UA26427A (uk)	1999-08-30	Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу
DE68903031D1 (de)	1992-11-05	N-acetyl-3-fluoroneuraminsaeure als antivirales arzneimittel.
NO902394L (no)	1990-12-03	Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
DE3851179D1 (de)	1994-09-29	Oxetanocin.
NO303783B1 (no)	1998-08-31	Substituerte aminofosfonatderivater og farmas°ytiske preparater derav
PT98658A (pt)	1992-06-30	Processo de obtencao de uma preparacao sob a forma de pulverizacao contendo nitroglicerina
DE69008668D1 (de)	1994-06-09	Synthese von Mannojirimycin-Derivaten.
RU93053038A (ru)	1996-09-20	Аналоги 15-деоксипергуалина, способ их получения и фармацевтическая композиция на их основе и промежуточные соединения синтеза
DK0487973T3 (da)	1996-07-29	Topisk lotion indeholdende niclosamid
FI884345A0 (fi)	1988-09-21	Sackaridderivat.
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
FI875729A0 (fi)	1987-12-28	Cytostatiska platinafoereningar.
FI901277A0 (fi)	1990-03-14	2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
FR2378518A1 (fr)	1978-08-25	Nouveaux medicaments a base de derives de tetrahydrodibenzopyranne
ES2123728T3 (es)	1999-01-16	Derivados de pirrolo-pirazina de actividad 5-ht3.
ES2064652T3 (es)	1995-02-01	Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato.
HUT73786A (en)	1996-09-30	Nitroxyalkylamide derivatives, process for producing them and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2007-06-15	REN	Ceased due to non-payment of the annual fee