ES2054327T3 - Sintesis de derivados de manojirimicina. - Google Patents

Sintesis de derivados de manojirimicina.

Info

Publication number
ES2054327T3
ES2054327T3 ES90870141T ES90870141T ES2054327T3 ES 2054327 T3 ES2054327 T3 ES 2054327T3 ES 90870141 T ES90870141 T ES 90870141T ES 90870141 T ES90870141 T ES 90870141T ES 2054327 T3 ES2054327 T3 ES 2054327T3
Authority
ES
Spain
Prior art keywords
homomannojirimycin
epi
configuration
alpha
manojirimicina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90870141T
Other languages
English (en)
Inventor
George William John Fleet
Ian Bruce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2054327T3 publication Critical patent/ES2054327T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

(ALFA)-HOMOMANOJIRIMICINA (1) Y 6-EPI-HOMOMANOJIRIMICINA (2) SON CADA UNA SINTETIZADAS DEL 2-AZIDO-2-DEOXI-3,4:6,7-DI-O-ISOPROPILIDENO-D-GLICERO-DTALO-HEPTONO-1,5-LACTONA (3) EN LA CUAL LA CADENA DE ACETONIDA LATERAL SE HIDROLIZA PARA DAR EL DIOL CORRESPONDIENTE QUE SERA ENTONCES PROTEGIDO CON UN AGENTE PROTECTOR SILIL PARA FORMAR UN ETER SILIL. EL ULTIMO COMPUESTO SE UTILIZA COMO UN INTERMEDIARIO DIVERGENTE EN EL QUE SE FORMA EL ANILLO DE PIPERIDINA UNIENDO LA FUNCION DEL NITROGENO CON C-02 A C-6 (A) CON INVERSION DE LA CONFIGURACION EN C-6 PARA FORMAR 6-EPI-HOMOMANOJIRIMICINA O (B) CON RETENCION DE LA CONFIGURACION EN C-6 PARA FORMAR (ALFA)HOMOMANOJIRIMICINA.
ES90870141T 1989-10-11 1990-09-04 Sintesis de derivados de manojirimicina. Expired - Lifetime ES2054327T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/419,806 US5011929A (en) 1989-05-15 1989-10-11 Synthesis of mannojirimycin derivatives

Publications (1)

Publication Number Publication Date
ES2054327T3 true ES2054327T3 (es) 1994-08-01

Family

ID=23663839

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90870141T Expired - Lifetime ES2054327T3 (es) 1989-10-11 1990-09-04 Sintesis de derivados de manojirimicina.

Country Status (8)

Country Link
US (1) US5011929A (es)
EP (1) EP0427694B1 (es)
JP (1) JP2942606B2 (es)
AT (1) ATE105283T1 (es)
CA (1) CA2024843C (es)
DE (1) DE69008668T2 (es)
DK (1) DK0427694T3 (es)
ES (1) ES2054327T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210089A (en) * 1992-02-04 1993-05-11 Monsanto Company D-rhamnono-1,5-lactone
US5250703A (en) * 1992-09-29 1993-10-05 Monsanto Company Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
AU1840101A (en) 1999-08-10 2001-03-05 Chancellor, Masters And Scholars Of The University Of Oxford, The Long chain n-alkyl compounds and oxo-derivatives thereof
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
KR100665194B1 (ko) * 2005-08-30 2007-01-04 주식회사 한림전자 전자부품 솔더용 고정홀더
JP2009545621A (ja) 2006-08-02 2009-12-24 ユナイテッド セラピューティクス コーポレーション ウィルス感染症のリポソーム処置
US20080131398A1 (en) * 2006-08-21 2008-06-05 United Therapeutics Corporation Combination therapy for treatment of viral infections
US20090252785A1 (en) * 2008-03-26 2009-10-08 University Of Oxford Endoplasmic reticulum targeting liposomes
KR20120059447A (ko) * 2009-03-27 2012-06-08 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 콜레스테롤 수준 저하 리포좀

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3024901A1 (de) * 1980-07-01 1982-01-28 Bayer Ag, 5090 Leverkusen Herbizide mittel auf basis von piperidin-derivaten
US4357360A (en) * 1980-11-13 1982-11-02 International Flavors & Fragrances Inc. Use of tricyclic alcohols, ethers and esters for augmenting or enhancing the aroma or taste of foodstuffs
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel

Also Published As

Publication number Publication date
JP2942606B2 (ja) 1999-08-30
CA2024843A1 (en) 1991-04-12
DE69008668D1 (de) 1994-06-09
DK0427694T3 (da) 1994-06-13
EP0427694B1 (en) 1994-05-04
DE69008668T2 (de) 1994-11-24
EP0427694A1 (en) 1991-05-15
CA2024843C (en) 2001-11-20
JPH03127775A (ja) 1991-05-30
ATE105283T1 (de) 1994-05-15
US5011929A (en) 1991-04-30

Similar Documents

Publication Publication Date Title
IL89921A0 (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
DE69010139D1 (de) Haarkräftigungsmittel.
ES2077138T3 (es) Derivados de aminocumarano, su produccion y su uso.
DE69027235D1 (de) Xanthinderivate
NO2011026I2 (no) Eribulin eller et farmasøytisk akseptabelt salt derav
ES2054327T3 (es) Sintesis de derivados de manojirimicina.
FI913882A0 (fi) Nitroglyserinhaltig, hydrofilisk, vattenhaltig pumpspray.
ATE86866T1 (de) Antikrebs-zusammensetzung.
FI892222A0 (fi) Peptidalkoholer med antikoagulantverkan.
DE69023559D1 (de) Derivate von Muramyldipeptid.
DE3888066D1 (de) Saccharid-Derivate.
MX9101270A (es) Compuesto,preparacion y uso
ATE90685T1 (de) Disaccharidderivate.
DK638787D0 (da) Anthracyclinderivater, deres fremstilling og anvendelse
FI901277A0 (fi) 2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
FR2378518A1 (fr) Nouveaux medicaments a base de derives de tetrahydrodibenzopyranne
ES2064652T3 (es) Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato.
ATE85056T1 (de) Tetracyclische indolderivate.
DE68909025D1 (de) Mittel zur Verhinderung von Zahnbelagbildung.
HU9401399D0 (en) Nitroxyalkylamide derivatives, process for producing them and pharmaceutical compositions containing them
ITNA920060V0 (it) Dispositivo antinfortunistico per cacciavite atto ad impedire la fuoriuscita della punta dallo spacco, portato dalla testa delle viti, durante ol lavoro,
FI905922A0 (fi) Antagonister foer a-adrenerga receptorer.
TH5978A (th) อนุพันธ์ไดแซ็กคาไรด์
IT8648750A0 (it) Camente accettabili,composizioni derivati xantinici 7-dialchilaminofarmaceutiche ad attivita' antibronetil sostituiti,loro sali fisiologi cospastica e relativo procedimentodi preparazione

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 427694

Country of ref document: ES