ATE105547T1 - Labile keto-derivate von 3-substituierten 1alkylamino-2-propanolen und deren verwendung als beta-adrenergische blocker. - Google Patents
Labile keto-derivate von 3-substituierten 1alkylamino-2-propanolen und deren verwendung als beta-adrenergische blocker.Info
- Publication number
- ATE105547T1 ATE105547T1 AT8888301615T AT88301615T ATE105547T1 AT E105547 T1 ATE105547 T1 AT E105547T1 AT 8888301615 T AT8888301615 T AT 8888301615T AT 88301615 T AT88301615 T AT 88301615T AT E105547 T1 ATE105547 T1 AT E105547T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- propanols
- blockers
- substitute
- labor
- Prior art date
Links
- KJDGFQJCHFJTRH-YONAWACDSA-N 16-Ketoestradiol Chemical class OC1=CC=C2[C@H]3CC[C@](C)([C@H](C(=O)C4)O)[C@@H]4[C@@H]3CCC2=C1 KJDGFQJCHFJTRH-YONAWACDSA-N 0.000 title 1
- 229930194542 Keto Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2600287A | 1987-03-16 | 1987-03-16 | |
| EP88301615A EP0283147B1 (de) | 1987-03-16 | 1988-02-25 | Labile Keto-Derivate von 3-substituierten 1-Alkylamino-2-propanolen und deren Verwendung als beta-adrenergische Blocker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE105547T1 true ATE105547T1 (de) | 1994-05-15 |
Family
ID=21829283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT8888301615T ATE105547T1 (de) | 1987-03-16 | 1988-02-25 | Labile keto-derivate von 3-substituierten 1alkylamino-2-propanolen und deren verwendung als beta-adrenergische blocker. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0283147B1 (de) |
| JP (2) | JPH01501797A (de) |
| KR (1) | KR960008766B1 (de) |
| AT (1) | ATE105547T1 (de) |
| AU (1) | AU609788B2 (de) |
| CA (1) | CA1335286C (de) |
| DE (2) | DE3889486T4 (de) |
| DK (1) | DK626588A (de) |
| ES (1) | ES2051831T3 (de) |
| FI (1) | FI94337C (de) |
| IE (1) | IE62828B1 (de) |
| NO (1) | NO171312C (de) |
| WO (1) | WO1988007036A1 (de) |
| ZA (1) | ZA881226B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU609788B2 (en) * | 1987-03-16 | 1991-05-09 | University Of Florida | Labile ketone derivatives of 3-substituted-1-alkylamino- 2-propanols and their use as beta-adrenergic blockers |
| US5177064A (en) * | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3619370A (en) * | 1969-04-21 | 1971-11-09 | Frosst & Co Charles E | Microbial reduction of thiadiazoles |
| DE2645710C2 (de) * | 1976-10-09 | 1985-06-27 | Merck Patent Gmbh, 6100 Darmstadt | Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung |
| JPS563862A (en) * | 1979-06-26 | 1981-01-16 | Nippon Denso Co | Refrigeration device |
| IL65541A0 (en) * | 1981-05-06 | 1982-07-30 | Haessle Ab | Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same |
| US4521414A (en) * | 1981-06-18 | 1985-06-04 | The Texas A&M University System | Ophthalmic compositions and their use for treating elevated intraocular pressure and glaucoma |
| EP0085286B1 (de) * | 1981-12-17 | 1986-04-30 | Aktiebolaget Hässle | Para-substituierte 3-Phenoxy-1-carbonylaminoalkylaminopropan-2-ole mit blockierenden Wirkungen bei Betarezeptoren |
| US4616022A (en) * | 1984-08-17 | 1986-10-07 | Warner-Lambert Company | Procaterol stabilization |
| AU609788B2 (en) * | 1987-03-16 | 1991-05-09 | University Of Florida | Labile ketone derivatives of 3-substituted-1-alkylamino- 2-propanols and their use as beta-adrenergic blockers |
-
1988
- 1988-02-16 AU AU13459/88A patent/AU609788B2/en not_active Expired
- 1988-02-16 WO PCT/US1988/000386 patent/WO1988007036A1/en not_active Ceased
- 1988-02-16 JP JP63501931A patent/JPH01501797A/ja active Granted
- 1988-02-22 IE IE47588A patent/IE62828B1/en not_active IP Right Cessation
- 1988-02-22 ZA ZA881226A patent/ZA881226B/xx unknown
- 1988-02-25 EP EP88301615A patent/EP0283147B1/de not_active Expired - Lifetime
- 1988-02-25 DE DE3889486T patent/DE3889486T4/de not_active Expired - Lifetime
- 1988-02-25 AT AT8888301615T patent/ATE105547T1/de not_active IP Right Cessation
- 1988-02-25 DE DE3889486A patent/DE3889486D1/de not_active Expired - Lifetime
- 1988-02-25 ES ES88301615T patent/ES2051831T3/es not_active Expired - Lifetime
- 1988-02-26 CA CA000560031A patent/CA1335286C/en not_active Expired - Fee Related
- 1988-11-10 DK DK626588A patent/DK626588A/da not_active Application Discontinuation
- 1988-11-15 FI FI885271A patent/FI94337C/fi active IP Right Grant
- 1988-11-15 NO NO885081A patent/NO171312C/no not_active IP Right Cessation
- 1988-12-16 KR KR1019880701483A patent/KR960008766B1/ko not_active Expired - Fee Related
-
1992
- 1992-10-19 JP JP4306006A patent/JPH06122624A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1988007036A1 (en) | 1988-09-22 |
| EP0283147B1 (de) | 1994-05-11 |
| NO885081D0 (no) | 1988-11-15 |
| AU609788B2 (en) | 1991-05-09 |
| NO171312B (no) | 1992-11-16 |
| JPH0518820B2 (de) | 1993-03-15 |
| DE3889486T2 (de) | 1994-09-01 |
| FI885271A0 (fi) | 1988-11-15 |
| JPH01501797A (ja) | 1989-06-22 |
| DE3889486D1 (de) | 1994-06-16 |
| NO171312C (no) | 1993-02-24 |
| KR890700573A (ko) | 1989-04-25 |
| ES2051831T3 (es) | 1994-07-01 |
| FI885271L (fi) | 1988-11-15 |
| ZA881226B (en) | 1988-08-17 |
| DK626588A (da) | 1988-12-08 |
| FI94337C (fi) | 1995-08-25 |
| AU1345988A (en) | 1988-10-10 |
| FI94337B (fi) | 1995-05-15 |
| JPH06122624A (ja) | 1994-05-06 |
| IE62828B1 (en) | 1995-03-08 |
| DK626588D0 (da) | 1988-11-10 |
| KR960008766B1 (ko) | 1996-07-03 |
| DE3889486T4 (de) | 1994-12-01 |
| CA1335286C (en) | 1995-04-18 |
| NO885081L (no) | 1989-01-13 |
| IE880475L (en) | 1988-09-16 |
| EP0283147A1 (de) | 1988-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |