ATE106087T1 - Synthetische inhibitoren von säugetier- collagenase. - Google Patents

Synthetische inhibitoren von säugetier- collagenase.

Info

Publication number: ATE106087T1
Authority: AT; Austria
Prior art keywords: carbon atoms; alkyl; hydrogen; amino acid; synthetic inhibitors
Prior art date: 1987-03-17

Application number

AT88903584T

Other languages

English (en)

Inventor

Robert D Gray

Arno F Spatola

Robert B Miller

Original Assignee

Res Corp Technologies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-17

Filing date

1988-03-17

Publication date

1994-06-15

1988-03-17 Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc

1994-06-15 Application granted granted Critical

1994-06-15 Publication of ATE106087T1 publication Critical patent/ATE106087T1/de

Links

102000029816 Collagenase Human genes 0.000 title 1
108060005980 Collagenase Proteins 0.000 title 1
229960002424 collagenase Drugs 0.000 title 1
239000012622 synthetic inhibitor Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 3
229940024606 amino acid Drugs 0.000 abstract 3
235000001014 amino acid Nutrition 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
NTOKKQYUXMUQQD-GDZDFWBTSA-N (2s,3s)-2-amino-3-methylpentanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound CC[C@H](C)[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 NTOKKQYUXMUQQD-GDZDFWBTSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88903584T 1987-03-17 1988-03-17 Synthetische inhibitoren von säugetier- collagenase. ATE106087T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2693387A	1987-03-17	1987-03-17

Publications (1)

Publication Number	Publication Date
ATE106087T1 true ATE106087T1 (de)	1994-06-15

Family

ID=21834639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88903584T ATE106087T1 (de)	1987-03-17	1988-03-17	Synthetische inhibitoren von säugetier- collagenase.

Country Status (5)

Country	Link
EP (1)	EP0358660B1 (de)
JP (1)	JP2586942B2 (de)
AT (1)	ATE106087T1 (de)
DE (1)	DE3889726T2 (de)
WO (1)	WO1988006890A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814813D0 (en) *	1988-06-22	1988-07-27	Beecham Group Plc	Novel compounds
US5268384A (en) *	1990-11-21	1993-12-07	Galardy Richard E	Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5239078A (en) *	1990-11-21	1993-08-24	Glycomed Incorporated	Matrix metalloprotease inhibitors
US5189178A (en) *	1990-11-21	1993-02-23	Galardy Richard E	Matrix metalloprotease inhibitors
US5594106A (en) *	1993-08-23	1997-01-14	Immunex Corporation	Inhibitors of TNF-α secretion
US5470834A (en) *	1993-10-06	1995-11-28	Florida State University	Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
GB9323165D0 (en) *	1993-11-10	1994-01-05	Chiros Ltd	Compounds
CZ288436B6 (en) *	1994-10-05	2001-06-13	Darwin Discovery Ltd	Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised
US5840698A (en) *	1994-10-27	1998-11-24	Affymax Technologies N.V.	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) *	1994-10-27	1998-11-03	Affymax Technologies N.V.	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
AU692102B2 (en) *	1995-05-10	1998-05-28	Darwin Discovery Limited	Peptidyl compounds and their therapeutic use
AU710502B2 (en) *	1995-05-10	1999-09-23	Darwin Discovery Limited	Peptidyl compounds which inhibit metalloproteinase and TNF liberation and their therapeutic use
EP0824543A1 (de) *	1995-05-10	1998-02-25	Chiroscience Limited	Peptide, die metalloproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
EP0826000B1 (de) *	1995-05-10	2002-10-23	Darwin Discovery Limited	Peptide, die metallproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
WO1997012902A1 (en) *	1995-10-05	1997-04-10	Darwin Discovery Limited	Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation
US5932579A (en)	1996-06-18	1999-08-03	Affymax Technologies N.V.	Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
ATE229034T1 (de) *	1996-09-19	2002-12-15	Aventis Pharma Inc	3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen
EP1150951A1 (de) *	1998-12-31	2001-11-07	Aventis Pharmaceuticals Inc.	3-substituierte pyrrolidine und ihre verwendung als matrixmetalloproteinase-hemmer
US6486193B2 (en)	1998-12-31	2002-11-26	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4113715A (en) *	1977-01-17	1978-09-12	E. R. Squibb & Sons, Inc.	Amino acid derivatives
US4611002A (en) *	1977-07-14	1986-09-09	E. R. Squibb And Sons, Inc.	Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
US4297275A (en) *	1979-06-25	1981-10-27	E. R. Squibb & Sons, Inc.	Inhibitors of mammalian collagenase
US4382081A (en) *	1981-06-12	1983-05-03	E. R. Squibb & Sons, Inc.	Inhibitors of mammalian collagenase
US4371466A (en) *	1981-10-07	1983-02-01	American Home Products Corporation	Mammalian collagenase inhibitors
US4371465A (en) *	1981-10-07	1983-02-01	American Home Products Corporation	Mammalian collagenase inhibitors
DE3243370A1 (de) *	1982-11-24	1984-05-24	Basf Ag, 6700 Ludwigshafen	Benzoylthioverbindungen, ihre herstellung und verwendung als arzneimittel
US4560506A (en) *	1984-05-25	1985-12-24	E. R. Squibb & Sons, Inc.	Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
US4595700A (en) *	1984-12-21	1986-06-17	G. D. Searle & Co.	Thiol based collagenase inhibitors
US4681966A (en) *	1985-02-21	1987-07-21	G. D. Searle & Co.	Intermediate for thiol based collagenase inhibitors

1988
- 1988-03-17 AT AT88903584T patent/ATE106087T1/de active
- 1988-03-17 EP EP88903584A patent/EP0358660B1/de not_active Expired - Lifetime
- 1988-03-17 JP JP63503218A patent/JP2586942B2/ja not_active Expired - Lifetime
- 1988-03-17 DE DE3889726T patent/DE3889726T2/de not_active Expired - Fee Related
- 1988-03-17 WO PCT/US1988/000879 patent/WO1988006890A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0358660A1 (de)	1990-03-21
EP0358660B1 (de)	1994-05-25
JPH02502537A (ja)	1990-08-16
DE3889726D1 (de)	1994-06-30
WO1988006890A1 (en)	1988-09-22
EP0358660A4 (en)	1991-01-09
JP2586942B2 (ja)	1997-03-05
DE3889726T2 (de)	1994-10-13

Publication	Publication Date	Title
ATE106087T1 (de)	1994-06-15	Synthetische inhibitoren von säugetier- collagenase.
IE801251L (en)	1980-12-25	Inhibitors of mammalian collagenase
GR3023130T3 (en)	1997-07-30	Phosphotriester-type biologically active compounds.
ES8705366A1 (es)	1987-05-01	Procedimiento para la obtencion de derivados de 5-amino-4- hidroxivalerilo
DE3270583D1 (en)	1986-05-22	Inhibitors of mammalian collagenase
ATE90107T1 (de)	1993-06-15	Peptide mit collagenase hemmender wirkung.
NO911787L (no)	1991-11-11	Peptidaminer samt fremgangsmaate for fremstilling derav ogmidler som inneholder disse som fibrin/-trombin-koaguleringsinhibitorer
ES8606394A1 (es)	1986-04-01	Procedimiento para la obtencion de tetrapeptidos sustituidos
NZ326238A (en)	1999-11-29	Compositons and methods for inhibiting nonenzymatic cross-linking and glycosylation (protein aging) using N-acylaminoalkylhydrazine carboximidamides
HUP9900390A2 (hu)	1999-06-28	Szerin-proteáz-inhibitorok és ezeket tartalmazó gyógyszerkészítmények
AU568578B2 (en)	1988-01-07	Corrosion inhibitors
ES2034324T3 (es)	1993-04-01	Procedimiento de sintesis industrial de alfa amino diacidos n alquilados o de esteres de ellos.
IL69292A (en)	1987-03-31	Muramyl peptides substituted by 1,2-diacylated-sn-glycero-3-hydroxyphosphoryl,their manufacture and pharmaceutical compositions containing them
NO983691D0 (no)	1998-08-12	Forbindelser tilhörende amidiniumfamilien, farmasöytiske preparater inneholdende disse samt anvendelse derav
ATE50558T1 (de)	1990-03-15	Verfahren zur optischen auftrennung racemischer gemische von alpha-naphthylpropionsaeuren.
EA200001107A1 (ru)	2001-04-23	ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
DE3462327D1 (en)	1987-03-12	Ureum fertilizer containing urease inhibitors
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.
ES8704896A1 (es)	1987-04-16	Procedimiento para la obtencion de azacicloalcanos y azaci- cloalquenos 1,3,4-trisustituidos
EP0331756A4 (en)	1990-12-12	Agents for prophylaxis and treatment of thrombopenia
ZA9610804B (en)	1997-06-30	4-Imidazolidinone compound process for its preparation and the pharmaceutical compositions which contain it