ES2099436T3 - Compuestos biologicamente activos de tipo fosfotriesteres. - Google Patents

Compuestos biologicamente activos de tipo fosfotriesteres.

Info

Publication number
ES2099436T3
ES2099436T3 ES93910147T ES93910147T ES2099436T3 ES 2099436 T3 ES2099436 T3 ES 2099436T3 ES 93910147 T ES93910147 T ES 93910147T ES 93910147 T ES93910147 T ES 93910147T ES 2099436 T3 ES2099436 T3 ES 2099436T3
Authority
ES
Spain
Prior art keywords
biologically active
active compounds
phosphotriester
type
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93910147T
Other languages
English (en)
Inventor
Gilles Gosselin
Jean-Louis Imbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206383A external-priority patent/FR2691463A1/fr
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Application granted granted Critical
Publication of ES2099436T3 publication Critical patent/ES2099436T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

EL PRESENTE INVENTO TIENE POR OBJETO UN COMPUESTO FOSFOTRIESTER QUE RESPONDE A LA FORMULA GENERAL (I) EN LA CUAL: R ES UN RADICAL S ARILO U OXIDICO, EVENTUALMENTE SUSTITUIDO EN ESPECIAL POR UN GRUPO OH, SH O NH2 Y, N ES IGUAL A ENTRE 1 A 4 PREFERENTEMENTE 1 O 2 Y NU ES UN RADICAL QUE CONSISTE EN UN RESTO BIOLOGICAMENTE ACTIVO O EL RESTO DE FOSFORILADO DE UN COMPUESTO QUE ES BIOLOGICAMENTE ACTIVO CUANDO LLEVA UN GRUPO FOSFATO O FOSFONATO.
ES93910147T 1992-05-25 1993-05-24 Compuestos biologicamente activos de tipo fosfotriesteres. Expired - Lifetime ES2099436T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9206383A FR2691463A1 (fr) 1992-05-25 1992-05-25 Dérivés nucléotidiques, leur préparation et leur application en thérapeutique.
FR9304117A FR2692265B1 (fr) 1992-05-25 1993-04-07 Composes biologiquement actifs de type phosphotriesters.

Publications (1)

Publication Number Publication Date
ES2099436T3 true ES2099436T3 (es) 1997-05-16

Family

ID=26229484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93910147T Expired - Lifetime ES2099436T3 (es) 1992-05-25 1993-05-24 Compuestos biologicamente activos de tipo fosfotriesteres.

Country Status (11)

Country Link
US (2) US6399589B1 (es)
EP (1) EP0642528B1 (es)
JP (1) JP3628324B2 (es)
AT (1) ATE147750T1 (es)
CA (1) CA2136622C (es)
DE (1) DE69307506T2 (es)
DK (1) DK0642528T3 (es)
ES (1) ES2099436T3 (es)
FR (1) FR2692265B1 (es)
GR (1) GR3023130T3 (es)
WO (1) WO1993024510A1 (es)

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FR2692265B1 (fr) 1996-11-08
GR3023130T3 (en) 1997-07-30
DE69307506D1 (de) 1997-02-27
JP3628324B2 (ja) 2005-03-09
US6399589B1 (en) 2002-06-04
WO1993024510A1 (fr) 1993-12-09
DK0642528T3 (da) 1997-07-21
CA2136622C (fr) 2006-01-03
DE69307506T2 (de) 1997-07-03
EP0642528A1 (fr) 1995-03-15
US20020037873A1 (en) 2002-03-28
US6555676B2 (en) 2003-04-29
JPH07507068A (ja) 1995-08-03
FR2692265A1 (fr) 1993-12-17
EP0642528B1 (fr) 1997-01-15
CA2136622A1 (fr) 1993-12-09
ATE147750T1 (de) 1997-02-15

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