ATE106388T1 - Verbesserte methode zur herstellung von einem zwischenprodukt zur bereitung von bambuterol. - Google Patents

Verbesserte methode zur herstellung von einem zwischenprodukt zur bereitung von bambuterol.

Info

Publication number: ATE106388T1
Authority: AT; Austria
Prior art keywords: pct; preparation; bambuterol; improved method; dimethylcarbamoyloxy
Prior art date: 1989-12-01

Application number

AT91900394T

Other languages

English (en)

Inventor

Peter Jaksch

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-01

Filing date

1990-11-29

Publication date

1994-06-15

1990-11-29 Application filed by Astra Ab filed Critical Astra Ab

1994-06-15 Application granted granted Critical

1994-06-15 Publication of ATE106388T1 publication Critical patent/ATE106388T1/de

Links

ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 title abstract 2
229960003060 bambuterol Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 abstract 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 2
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
WQXWIKCZNIGMAP-UHFFFAOYSA-N 3',5'-Dihydroxyacetophenone Chemical compound CC(=O)C1=CC(O)=CC(O)=C1 WQXWIKCZNIGMAP-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 1
YIIMEMSDCNDGTB-UHFFFAOYSA-N Dimethylcarbamoyl chloride Chemical compound CN(C)C(Cl)=O YIIMEMSDCNDGTB-UHFFFAOYSA-N 0.000 abstract 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229940043232 butyl acetate Drugs 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
229940093499 ethyl acetate Drugs 0.000 abstract 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 abstract 1
229940011051 isopropyl acetate Drugs 0.000 abstract 1
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
238000010791 quenching Methods 0.000 abstract 1
230000000171 quenching effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Fats And Perfumes (AREA)

AT91900394T 1989-12-01 1990-11-29 Verbesserte methode zur herstellung von einem zwischenprodukt zur bereitung von bambuterol. ATE106388T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8904064A SE8904064D0 (sv)	1989-12-01	1989-12-01	Improved method of preparing an intermediate for the manufacture of bambuterol

Publications (1)

Publication Number	Publication Date
ATE106388T1 true ATE106388T1 (de)	1994-06-15

Family

ID=20377664

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91900394T ATE106388T1 (de)	1989-12-01	1990-11-29	Verbesserte methode zur herstellung von einem zwischenprodukt zur bereitung von bambuterol.

Country Status (14)

Country	Link
US (1)	US5200551A (de)
EP (1)	EP0456799B1 (de)
JP (1)	JPH04503218A (de)
AT (1)	ATE106388T1 (de)
AU (1)	AU630013B2 (de)
CA (1)	CA2045554A1 (de)
DE (1)	DE69009461T2 (de)
DK (1)	DK0456799T3 (de)
ES (1)	ES2054483T3 (de)
IE (1)	IE65994B1 (de)
NO (1)	NO174804B (de)
PT (1)	PT96051B (de)
SE (1)	SE8904064D0 (de)
WO (1)	WO1991008197A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1856036B1 (de) *	2004-11-08	2016-12-14	Emcure Pharmaceuticals Limited	Effizientes verfahren zur herstellung von (s)-3-[(1-dimethylamino)ethyl]-phenyl-n-ethyl-n-methylcarbamat
ES2301439B1 (es) *	2005-08-31	2009-05-01	Universidad De Malaga	Uso de aminoacido tipo micosporina (m-gly) como antioxidante o aditivo en productos alimentarios.
KR100701743B1 (ko)	2005-10-05	2007-03-29	주식회사 라이트팜텍	밤부테롤의 신규한 제조 방법
CN102617404A (zh) *	2012-04-06	2012-08-01	张长利	盐酸班布特罗及其中间体的制备工艺
CN104262202B (zh) *	2014-09-12	2016-12-07	广东东阳光药业有限公司	班布特罗中间体的制备工艺
CN106187820B (zh) *	2016-07-02	2017-09-19	深圳市康立生生物科技有限公司	一种班布特罗杂质b的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3404975A (en) *	1964-12-18	1968-10-08	Fmc Corp	m-(carbamoyloxy)-carbanilates as herbicides
CY1273A (en) *	1980-07-09	1985-03-08	Draco Ab	1-(dihydroxyphenyl)-2-amino-ethanol derivatives;preparation,compositions and intermediates
DE3441108A1 (de) *	1984-11-10	1986-05-15	Basf Ag, 6700 Ludwigshafen	Verfahren zur herstellung von o-(1-methoxy-2-chlor)-ethoxyphenyl-n-methylcarbamat
US4925971A (en) *	1987-12-08	1990-05-15	Asahi Kasei Kogyo Kabushiki Kaisha	Method for producing aliphatic o-arylurethanes

1989
- 1989-12-01 SE SE8904064A patent/SE8904064D0/xx unknown
1990
- 1990-11-20 US US07/741,424 patent/US5200551A/en not_active Expired - Fee Related
- 1990-11-26 IE IE424790A patent/IE65994B1/en not_active IP Right Cessation
- 1990-11-29 DE DE69009461T patent/DE69009461T2/de not_active Expired - Fee Related
- 1990-11-29 CA CA002045554A patent/CA2045554A1/en not_active Abandoned
- 1990-11-29 AU AU68981/91A patent/AU630013B2/en not_active Ceased
- 1990-11-29 EP EP91900394A patent/EP0456799B1/de not_active Expired - Lifetime
- 1990-11-29 WO PCT/SE1990/000792 patent/WO1991008197A1/en not_active Ceased
- 1990-11-29 AT AT91900394T patent/ATE106388T1/de not_active IP Right Cessation
- 1990-11-29 JP JP3501014A patent/JPH04503218A/ja active Pending
- 1990-11-29 ES ES91900394T patent/ES2054483T3/es not_active Expired - Lifetime
- 1990-11-29 DK DK91900394.7T patent/DK0456799T3/da active
- 1990-11-30 PT PT96051A patent/PT96051B/pt not_active IP Right Cessation
1991
- 1991-07-19 NO NO912853A patent/NO174804B/no unknown

Also Published As

Publication number	Publication date
EP0456799A1 (de)	1991-11-21
PT96051B (pt)	1998-02-27
DE69009461D1 (de)	1994-07-07
NO174804C (de)	1994-07-13
WO1991008197A1 (en)	1991-06-13
ES2054483T3 (es)	1994-08-01
NO174804B (no)	1994-04-05
SE8904064D0 (sv)	1989-12-01
IE65994B1 (en)	1995-11-29
CA2045554A1 (en)	1991-06-02
EP0456799B1 (de)	1994-06-01
DK0456799T3 (da)	1994-10-03
JPH04503218A (ja)	1992-06-11
NO912853L (no)	1991-07-19
DE69009461T2 (de)	1994-10-13
IE904247A1 (en)	1991-06-05
NO912853D0 (no)	1991-07-19
US5200551A (en)	1993-04-06
AU6898191A (en)	1991-06-26
PT96051A (pt)	1991-09-13
AU630013B2 (en)	1992-10-15

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
1998-08-15	REN	Ceased due to non-payment of the annual fee