ATE106867T1 - 13-trans-retinsäureester. - Google Patents

13-trans-retinsäureester.

Info

Publication number
ATE106867T1
ATE106867T1 AT88906459T AT88906459T ATE106867T1 AT E106867 T1 ATE106867 T1 AT E106867T1 AT 88906459 T AT88906459 T AT 88906459T AT 88906459 T AT88906459 T AT 88906459T AT E106867 T1 ATE106867 T1 AT E106867T1
Authority
AT
Austria
Prior art keywords
trans
retin
acid ester
acne
amides
Prior art date
Application number
AT88906459T
Other languages
English (en)
Inventor
Harlie A Parish
William P Purcell
Original Assignee
Molecular Design Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Design Int filed Critical Molecular Design Int
Application granted granted Critical
Publication of ATE106867T1 publication Critical patent/ATE106867T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Liquid Crystal Substances (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88906459T 1987-06-29 1988-06-27 13-trans-retinsäureester. ATE106867T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/067,536 US4885311A (en) 1987-06-29 1987-06-29 Topical transretinoids for treatment of acne and skin diseases

Publications (1)

Publication Number Publication Date
ATE106867T1 true ATE106867T1 (de) 1994-06-15

Family

ID=22076659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88906459T ATE106867T1 (de) 1987-06-29 1988-06-27 13-trans-retinsäureester.

Country Status (7)

Country Link
US (1) US4885311A (de)
EP (1) EP0366713B1 (de)
JP (1) JPH03500643A (de)
AT (1) ATE106867T1 (de)
AU (1) AU607097B2 (de)
DE (1) DE3850109T2 (de)
WO (1) WO1989000157A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124356A (en) * 1987-06-29 1992-06-23 Molecular Design International, Inc. Dermal uses of trans-retinoids for the treatment of photoaging
US4994491A (en) * 1988-12-14 1991-02-19 Molecular Design International Dermal uses of trans-retinoids for the treatment of cancer
US5049584A (en) * 1988-12-14 1991-09-17 Molecular Design International Dermal uses of cis-retinoids for the treatment of cancer
FR2644459B1 (fr) * 1989-03-16 1994-10-28 Oreal Esters retinoiques de l-cladinose, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
FR2644460A1 (fr) * 1989-03-16 1990-09-21 Oreal Esters retinoiques de d-desosamine, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
US5235076A (en) * 1991-05-28 1993-08-10 University Of Hawaii Azulenic retinoid compounds, compositions and methods
EP0617614B1 (de) * 1991-12-18 1998-03-04 The Salk Institute For Biological Studies Mitteln zur modulierung von verfahren durch retinoid rezeptoren und dafür nützliche verbindungen
US6040342A (en) * 1994-09-16 2000-03-21 Bar-Ilan University Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
US6071923A (en) * 1994-09-16 2000-06-06 Bar-Ilan University Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases
US5710176A (en) * 1994-09-16 1998-01-20 Bar-Ilan University Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
IT1276459B1 (it) * 1995-06-30 1997-10-31 Khodor Ammar Composizioni cosmetiche con proprieta' antimicotiche, efficaci contro la psoriasi e la caduta dei capelli e metodo cosmetico per la
CA2258593A1 (en) * 1996-07-02 1998-01-08 Abraham Nudelman Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases
US6130248A (en) * 1996-12-30 2000-10-10 Bar-Ilan University Tricarboxylic acid-containing oxyalkyl esters and uses thereof
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US6124495A (en) 1997-03-11 2000-09-26 Beacon Laboratories, Inc. Unsaturated oxyalkylene esters and uses thereof
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
US6110970A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Nitrogen-containing oxyalkylene esters and uses thereof
US6030961A (en) * 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
AU2002249958B2 (en) 2001-01-16 2007-11-08 Vascular Therapies, Inc. Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
US20020182237A1 (en) 2001-03-22 2002-12-05 The Procter & Gamble Company Skin care compositions containing a sugar amine
US7235249B2 (en) 2002-03-28 2007-06-26 The Procter & Gamble Company Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
JP2005020400A (ja) * 2003-06-26 2005-01-20 Hitachi Communication Technologies Ltd 無線基地局、無線通信システム、無線基地局の通信制御方法、および、無線通信網の構築方法
JP4699347B2 (ja) * 2003-01-17 2011-06-08 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 改質されたレチノイド化合物及びその使用
CA2513586A1 (en) * 2003-01-17 2004-08-05 Wisconsin Alumni Research Foundation Method of reducing toxicity of retinoids
US20040175347A1 (en) 2003-03-04 2004-09-09 The Procter & Gamble Company Regulation of mammalian keratinous tissue using hexamidine compositions
FR2854897B1 (fr) * 2003-05-12 2007-05-04 Sederma Sa Compositions cosmetiques ou dermopharmaceutiques pour reduire les signes du vieillissement cutane.
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
FR2880802B1 (fr) * 2005-01-14 2008-12-19 Sederma Soc Par Actions Simpli Composition cosmetique ou dermopharmaceutique contenant un extrait d'euglene
US20080095732A1 (en) * 2005-04-27 2008-04-24 Rosemarie Osborne Personal care compositions
US20070020220A1 (en) * 2005-04-27 2007-01-25 Procter & Gamble Personal care compositions
US9616011B2 (en) 2005-04-27 2017-04-11 The Procter & Gamble Company Personal care compositions
FR2885522B1 (fr) * 2005-05-13 2020-01-10 Sederma Composition cosmetique ou dermopharmaceutique contenant de la teprenone
FR2890310B1 (fr) * 2005-09-06 2009-04-03 Sederma Soc Par Actions Simpli Utilisation des protoberberines comme agents regulant l'activite de l'unite pilosebacee
EP3015101B1 (de) 2005-10-03 2019-08-21 PINSKY, Mark A. Non-phospholipid liposomen enthaltend hyaluronsäure
US20070202061A1 (en) * 2005-10-31 2007-08-30 Naturalnano, Inc. Cosmetic skincare applications employing mineral-derived tubules for controlled release
US8404648B2 (en) * 2006-02-16 2013-03-26 Sederma Polypeptides KXK and their use
FR2900573B1 (fr) 2006-05-05 2014-05-16 Sederma Sa Nouvelles compositions cosmetiques renfermant au moins un peptide contenant au moins un cycle aromatique bloque
FR2904549B1 (fr) * 2006-08-03 2012-12-14 Sederma Sa Composition comprenant de la sarsasapogenine
CN100475189C (zh) 2006-10-17 2009-04-08 王海龙 一种化妆品组合物及其制备方法和应用
US20080139518A1 (en) * 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
US8299122B2 (en) * 2008-04-14 2012-10-30 Skinvisible Pharmaceuticals, Inc. Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
FR2939799B1 (fr) 2008-12-11 2011-03-11 Sederma Sa Composition cosmetique comprenant des oligoglucuronanes acetyles.
FR2941232B1 (fr) 2009-01-16 2014-08-08 Sederma Sa Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques.
EP3744729B1 (de) 2009-01-16 2023-03-01 Sederma Peptide, zusammensetzungen damit und kosmetische und dermopharmazeutische verwendungen
FR2941231B1 (fr) 2009-01-16 2016-04-01 Sederma Sa Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques.
FR2944435B1 (fr) 2009-04-17 2011-05-27 Sederma Sa Composition cosmetique comprenant de l'oridonine
FR2945939B1 (fr) 2009-05-26 2011-07-15 Sederma Sa Utilisation cosmetique du dipeptide tyr-arg pour lutter contre le relachement cutane.
KR101701548B1 (ko) 2009-10-06 2017-02-01 바스프 에스이 벤조트로폴론을 함유하는 식물 추출물 및/또는 관련 벤조트로폴론 유도체의 사용에 의한 가정용 제품, 바디-관리 제품 및 식품의 안정화
US8425885B2 (en) 2009-11-09 2013-04-23 Conopco, Inc. Substituted 3-(phenoxymethyl) benzyl amines and personal care compositions
US8309064B2 (en) 2009-11-09 2012-11-13 Conopco, Inc. Skin care compositions comprising phenoxyalkyl amines
WO2012006107A2 (en) 2010-06-28 2012-01-12 Stemtide, Inc. Skin care compositions
US8476251B2 (en) 2010-07-29 2013-07-02 Conopco, Inc. Skin care compositions comprising substituted diamines
US8293218B2 (en) 2010-07-29 2012-10-23 Conopco, Inc. Skin care compositions comprising substituted monoamines
US9737472B2 (en) 2010-08-09 2017-08-22 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
US10842728B2 (en) 2010-08-09 2020-11-24 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
US9205284B2 (en) 2010-08-09 2015-12-08 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
US20120122936A1 (en) 2010-11-11 2012-05-17 Conopco, Inc., D/B/A Unilever Leave-on nonsolid skin conditioning compositions containing 12-[(12-hydroxyoctadecanoyl)oxy] octadecanoic acid
EP2637636B1 (de) 2010-11-11 2019-02-20 Unilever PLC Auf der haut verbleibende nichtfeste hautpflegezusammensetzungen mit 12-hydroxystearinsäure
US8613939B2 (en) 2010-12-15 2013-12-24 Conopco, Inc. Leave-on nonsolid skin conditioning compositions containing 12-hydroxystearic acid and ethoxylated hydrogenated castor oil
US20120214871A1 (en) 2011-02-17 2012-08-23 Conopco, Inc., D/B/A Unilever Leave-on nonsolid oil-continuous skin conditioning compositions containing 12-hydroxystearic acid
US20120283112A1 (en) 2011-02-22 2012-11-08 The Procter & Gamble Company Systems and Methods for Identifying Cosmetic Agents for Skin Care Compositions
WO2012135651A1 (en) 2011-03-31 2012-10-04 The Procter & Gamble Company Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis
EP2717967A2 (de) 2011-06-13 2014-04-16 The Procter & Gamble Company Körperpflegezusammensetzungen mit ph-abstimmbarem geliermittel und verwendungsverfahren
EP2717966A2 (de) 2011-06-13 2014-04-16 The Procter and Gamble Company Körperpflegezusammensetzungen mit einem di-amid-geliermittel und verwendungsverfahren
WO2012177757A2 (en) 2011-06-20 2012-12-27 The Procter & Gamble Company Personal care compositions comprising shaped abrasive particles
US20140328952A1 (en) 2011-12-21 2014-11-06 Dana FLAVIN Topical compositions
JP6209169B2 (ja) 2012-02-20 2017-10-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ポリマーを用いた殺生物剤の抗微生物活性の増強
US10418127B2 (en) 2012-03-30 2019-09-17 The Procter & Gamble Company Method of formulating a skin-lightening composition
JP2015527630A (ja) 2012-06-06 2015-09-17 ザ プロクター アンド ギャンブルカンパニー ヘア／頭皮ケア組成物向け化粧剤の同定システム及び方法
US9271912B2 (en) 2012-06-13 2016-03-01 The Procter & Gamble Company Personal care compositions comprising a pH tuneable gellant and methods of using
EP2885637B1 (de) 2012-08-15 2016-11-30 The Procter & Gamble Company Verwendung eines menschliches ex-vivo-hautmodells bei der identifizierung von modulatoren von hautentzündungen
JP2015531127A (ja) 2012-08-15 2015-10-29 ザ プロクター アンド ギャンブルカンパニー 皮膚疾患の配列の治療に有効な皮膚活性剤を特定及び評価するためのシステム、モデル、及び方法
US9682028B2 (en) 2013-03-13 2017-06-20 Conopco, Inc. Personal care photoprotective compositions with tricyclodecane amides
ITMI20130995A1 (it) * 2013-06-17 2014-12-18 Chemelectiva S R L Derivati dell'acido retinoico e processo per la loro preparazione
EP3080142B1 (de) 2013-12-10 2018-01-31 Sussex Research Laboratories Inc. Glycopeptidzusammensetzungen und verwendungen davon
US20160000682A1 (en) 2014-07-02 2016-01-07 Geoffrey Brooks Consultants Llc Peptide-Based Compositions and Methods of Use
EP3288926B1 (de) 2015-04-28 2021-01-20 Unilever PLC Aralkylcarboxamido-piperazin- und -homopiperazin-verbindungen und körperpflegezusammensetzungen diese enthaltend
CN107548387B (zh) 2015-04-28 2020-08-25 荷兰联合利华有限公司 N-芳烷基羰基二胺化合物以及包含它们的个人护理组合物
WO2017080758A1 (en) 2015-11-10 2017-05-18 Unilever Plc Cyclocarboxylic acid containing personal care compositions
CN109562043B (zh) 2016-07-27 2022-04-08 联合利华知识产权控股有限公司 包含脂肪酸酰胺衍生物的个人护理组合物
WO2018081591A1 (en) 2016-10-28 2018-05-03 Coty Inc. Topical composition
JP7084924B2 (ja) 2016-12-21 2022-06-15 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ 難溶性化合物を含むパーソナルケア組成物
EA201991185A1 (ru) 2016-12-21 2020-01-13 Юнилевер Н.В. Композиции для личной гигиены, содержащие цистин
WO2018154145A2 (en) * 2018-03-29 2018-08-30 Symrise Ag Compounds for skin improvement / treatment
GB201811312D0 (en) 2018-07-10 2018-08-29 Nuchido Ltd Compositions
US20230157939A1 (en) 2020-04-28 2023-05-25 Conopco, Inc., D/B/A Unilever Personal care compositions with enhanced solubility actives
WO2022008732A1 (en) 2020-07-10 2022-01-13 Basf Se Enhancing the activity of antimicrobial preservatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2917523A (en) * 1959-12-15 Production of compounds of the
US2424994A (en) * 1944-06-20 1947-08-05 Research Corp Vitamin a acid and its esters and method of making them
US2576103A (en) * 1946-12-24 1951-11-27 Eastman Kodak Co Synthesis of vitamin a active compounds containing repeated isoprene units
US2951853A (en) * 1957-06-08 1960-09-06 Sumitomo Chemical Co Method for preparing polyenecarboxylic acid derivatives
FR2059478A1 (en) * 1969-07-04 1971-06-04 Hoffmann La Roche Anticarcinogenic compns contng vitamin a - acids
ZA71145B (en) * 1970-02-02 1971-10-27 Hoffmann La Roche Use of vitamin a-acid
DE2050658A1 (en) * 1970-10-15 1972-05-25 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Vitamin a acid isopropyl ester - active against skin diseases
JPS5921863B2 (ja) * 1973-11-07 1984-05-22 日清製粉 （株） 新規なビタミンａ酸エステルの製造法
JPS5827266B2 (ja) * 1973-11-07 1983-06-08 ニツシンセイフン カブシキガイシヤ シンキナビタミン ａ サンエステル ノ セイゾウホウ
US3984544A (en) * 1975-02-28 1976-10-05 Schering Corporation Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
US4055659A (en) * 1975-11-03 1977-10-25 Johnson & Johnson Retinoic acid derivatives
US4216224A (en) * 1978-09-22 1980-08-05 Scott Eugene J Van Methods and compositions for treating psoriasis with retinoyl compounds
GB2097783B (en) * 1981-04-23 1984-12-12 Dermal Lab Ltd Imidazoles
US4529600A (en) * 1982-09-09 1985-07-16 Sri International Pentadeuterioretinoids
US4677120A (en) * 1985-07-31 1987-06-30 Molecular Design International Topical prodrugs for treatment of acne and skin diseases
WO1988009788A1 (en) * 1987-06-12 1988-12-15 Molecular Design International, Inc. Topical prodrugs for treatment of acne and skin diseases
DK498487A (da) * 1986-10-06 1988-04-07 Hoffmann La Roche Hidtil ukendte retinoider

Also Published As

Publication number Publication date
EP0366713A1 (de) 1990-05-09
DE3850109T2 (de) 1994-10-06
DE3850109D1 (de) 1994-07-14
WO1989000157A1 (en) 1989-01-12
US4885311A (en) 1989-12-05
AU607097B2 (en) 1991-02-21
AU2080988A (en) 1989-01-30
JPH03500643A (ja) 1991-02-14
EP0366713B1 (de) 1994-06-08

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