ATE106867T1 - 13-trans-retinsäureester. - Google Patents

13-trans-retinsäureester.

Info

Publication number
ATE106867T1
ATE106867T1 AT88906459T AT88906459T ATE106867T1 AT E106867 T1 ATE106867 T1 AT E106867T1 AT 88906459 T AT88906459 T AT 88906459T AT 88906459 T AT88906459 T AT 88906459T AT E106867 T1 ATE106867 T1 AT E106867T1
Authority
AT
Austria
Prior art keywords
trans
retin
acid ester
acne
amides
Prior art date
Application number
AT88906459T
Other languages
English (en)
Inventor
Harlie A Parish
William P Purcell
Original Assignee
Molecular Design Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Design Int filed Critical Molecular Design Int
Application granted granted Critical
Publication of ATE106867T1 publication Critical patent/ATE106867T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Liquid Crystal Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT88906459T 1987-06-29 1988-06-27 13-trans-retinsäureester. ATE106867T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/067,536 US4885311A (en) 1987-06-29 1987-06-29 Topical transretinoids for treatment of acne and skin diseases

Publications (1)

Publication Number Publication Date
ATE106867T1 true ATE106867T1 (de) 1994-06-15

Family

ID=22076659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88906459T ATE106867T1 (de) 1987-06-29 1988-06-27 13-trans-retinsäureester.

Country Status (7)

Country Link
US (1) US4885311A (de)
EP (1) EP0366713B1 (de)
JP (1) JPH03500643A (de)
AT (1) ATE106867T1 (de)
AU (1) AU607097B2 (de)
DE (1) DE3850109T2 (de)
WO (1) WO1989000157A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124356A (en) * 1987-06-29 1992-06-23 Molecular Design International, Inc. Dermal uses of trans-retinoids for the treatment of photoaging
US4994491A (en) * 1988-12-14 1991-02-19 Molecular Design International Dermal uses of trans-retinoids for the treatment of cancer
US5049584A (en) * 1988-12-14 1991-09-17 Molecular Design International Dermal uses of cis-retinoids for the treatment of cancer
FR2644460A1 (fr) * 1989-03-16 1990-09-21 Oreal Esters retinoiques de d-desosamine, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
FR2644459B1 (fr) * 1989-03-16 1994-10-28 Oreal Esters retinoiques de l-cladinose, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
US5235076A (en) * 1991-05-28 1993-08-10 University Of Hawaii Azulenic retinoid compounds, compositions and methods
JP4001618B2 (ja) * 1991-12-18 2007-10-31 ザ ソールク インスチチュート フォア バイオロジカル スタディズ レチノイド受容体によって仲介される過程の修飾方法およびそれに有用な化合物
US5710176A (en) * 1994-09-16 1998-01-20 Bar-Ilan University Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
US6071923A (en) * 1994-09-16 2000-06-06 Bar-Ilan University Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases
US6040342A (en) * 1994-09-16 2000-03-21 Bar-Ilan University Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
IT1276459B1 (it) 1995-06-30 1997-10-31 Khodor Ammar Composizioni cosmetiche con proprieta' antimicotiche, efficaci contro la psoriasi e la caduta dei capelli e metodo cosmetico per la
WO1998000127A1 (en) * 1996-07-02 1998-01-08 Bar-Ilan University Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases
US6130248A (en) * 1996-12-30 2000-10-10 Bar-Ilan University Tricarboxylic acid-containing oxyalkyl esters and uses thereof
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
US6030961A (en) * 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US6110970A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Nitrogen-containing oxyalkylene esters and uses thereof
US6124495A (en) 1997-03-11 2000-09-26 Beacon Laboratories, Inc. Unsaturated oxyalkylene esters and uses thereof
US6110955A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Metabolically stabilized oxyalkylene esters and uses thereof
AU2002249958B2 (en) 2001-01-16 2007-11-08 Vascular Therapies, Inc. Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
US20020182237A1 (en) 2001-03-22 2002-12-05 The Procter & Gamble Company Skin care compositions containing a sugar amine
US7235249B2 (en) 2002-03-28 2007-06-26 The Procter & Gamble Company Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
JP2005020400A (ja) * 2003-06-26 2005-01-20 Hitachi Communication Technologies Ltd 無線基地局、無線通信システム、無線基地局の通信制御方法、および、無線通信網の構築方法
AU2004205644B2 (en) * 2003-01-17 2011-03-17 Wisconsin Alumni Research Foundation Method of reducing toxicity of retinoids
WO2004064743A2 (en) * 2003-01-17 2004-08-05 Wisconsin Alumni Research Foundation Modified retinoid compounds and their uses
US20040175347A1 (en) 2003-03-04 2004-09-09 The Procter & Gamble Company Regulation of mammalian keratinous tissue using hexamidine compositions
FR2854897B1 (fr) * 2003-05-12 2007-05-04 Sederma Sa Compositions cosmetiques ou dermopharmaceutiques pour reduire les signes du vieillissement cutane.
US20050014729A1 (en) * 2003-07-16 2005-01-20 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
FR2880802B1 (fr) * 2005-01-14 2008-12-19 Sederma Soc Par Actions Simpli Composition cosmetique ou dermopharmaceutique contenant un extrait d'euglene
US9616011B2 (en) 2005-04-27 2017-04-11 The Procter & Gamble Company Personal care compositions
US20080095732A1 (en) * 2005-04-27 2008-04-24 Rosemarie Osborne Personal care compositions
US20070020220A1 (en) 2005-04-27 2007-01-25 Procter & Gamble Personal care compositions
FR2885522B1 (fr) * 2005-05-13 2020-01-10 Sederma Composition cosmetique ou dermopharmaceutique contenant de la teprenone
FR2890310B1 (fr) * 2005-09-06 2009-04-03 Sederma Soc Par Actions Simpli Utilisation des protoberberines comme agents regulant l'activite de l'unite pilosebacee
ES2661728T3 (es) 2005-10-03 2018-04-03 Pinksky, Mark A. Composiciones y métodos para el cuidado mejorado de la piel
US20070202061A1 (en) * 2005-10-31 2007-08-30 Naturalnano, Inc. Cosmetic skincare applications employing mineral-derived tubules for controlled release
WO2007093839A1 (en) * 2006-02-16 2007-08-23 Sederma New polypeptides kxk and their use
FR2900573B1 (fr) * 2006-05-05 2014-05-16 Sederma Sa Nouvelles compositions cosmetiques renfermant au moins un peptide contenant au moins un cycle aromatique bloque
FR2904549B1 (fr) * 2006-08-03 2012-12-14 Sederma Sa Composition comprenant de la sarsasapogenine
CN100475189C (zh) 2006-10-17 2009-04-08 王海龙 一种化妆品组合物及其制备方法和应用
WO2008070116A2 (en) 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
US8299122B2 (en) * 2008-04-14 2012-10-30 Skinvisible Pharmaceuticals, Inc. Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
FR2939799B1 (fr) 2008-12-11 2011-03-11 Sederma Sa Composition cosmetique comprenant des oligoglucuronanes acetyles.
FR2941232B1 (fr) 2009-01-16 2014-08-08 Sederma Sa Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques.
FR2941231B1 (fr) 2009-01-16 2016-04-01 Sederma Sa Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques.
WO2010082177A2 (en) 2009-01-16 2010-07-22 Sederma New compounds, in particular peptides, compositions comprising them and cosmetic and dermopharmaceutical uses
FR2944435B1 (fr) 2009-04-17 2011-05-27 Sederma Sa Composition cosmetique comprenant de l'oridonine
FR2945939B1 (fr) 2009-05-26 2011-07-15 Sederma Sa Utilisation cosmetique du dipeptide tyr-arg pour lutter contre le relachement cutane.
MX2012003820A (es) 2009-10-06 2012-05-17 Basf Se Estabilizacion de productos para el hogar, para el cuidado corporal y alimenticios al usar extractos de planta que contienen benzotropolona y/o derivados de benzotropolona relacionados.
US8425885B2 (en) 2009-11-09 2013-04-23 Conopco, Inc. Substituted 3-(phenoxymethyl) benzyl amines and personal care compositions
US8309064B2 (en) 2009-11-09 2012-11-13 Conopco, Inc. Skin care compositions comprising phenoxyalkyl amines
WO2012006107A2 (en) 2010-06-28 2012-01-12 Stemtide, Inc. Skin care compositions
US8293218B2 (en) 2010-07-29 2012-10-23 Conopco, Inc. Skin care compositions comprising substituted monoamines
US8476251B2 (en) 2010-07-29 2013-07-02 Conopco, Inc. Skin care compositions comprising substituted diamines
US9205284B2 (en) 2010-08-09 2015-12-08 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
US9737472B2 (en) 2010-08-09 2017-08-22 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
US10842728B2 (en) 2010-08-09 2020-11-24 Allele Biotechnology & Pharmaceuticals, Inc. Light-absorbing compositions and methods of use
MX343424B (es) 2010-11-11 2016-11-04 Unilever Nv Composiciones acondicionadoras de la piel no solidas, que se dejan puestas, conteniendo acido 12-hidroxiestearico.
US20120122936A1 (en) 2010-11-11 2012-05-17 Conopco, Inc., D/B/A Unilever Leave-on nonsolid skin conditioning compositions containing 12-[(12-hydroxyoctadecanoyl)oxy] octadecanoic acid
US8613939B2 (en) 2010-12-15 2013-12-24 Conopco, Inc. Leave-on nonsolid skin conditioning compositions containing 12-hydroxystearic acid and ethoxylated hydrogenated castor oil
US20120214871A1 (en) 2011-02-17 2012-08-23 Conopco, Inc., D/B/A Unilever Leave-on nonsolid oil-continuous skin conditioning compositions containing 12-hydroxystearic acid
WO2012116081A2 (en) 2011-02-22 2012-08-30 The Procter & Gamble Company Methods for identifying cosmetic agents for skin care compositions
EP2691539B1 (de) 2011-03-31 2018-04-25 The Procter and Gamble Company Verfahren zur identifizierung und evaluierung von haut-wirkstoffen wirksam bei der behandlung von schuppen
EP2717967A2 (de) 2011-06-13 2014-04-16 The Procter & Gamble Company Körperpflegezusammensetzungen mit ph-abstimmbarem geliermittel und verwendungsverfahren
CN103930167A (zh) 2011-06-13 2014-07-16 宝洁公司 包含二酰氨基胶凝剂的个人护理组合物和使用方法
JP5902810B2 (ja) 2011-06-20 2016-04-13 ザ プロクター アンド ギャンブル カンパニー 成形研磨粒子を含むパーソナルケア組成物
WO2013091894A2 (en) 2011-12-21 2013-06-27 Flavin Dana Topical compositions
JP6209169B2 (ja) 2012-02-20 2017-10-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ポリマーを用いた殺生物剤の抗微生物活性の増強
US10418127B2 (en) 2012-03-30 2019-09-17 The Procter & Gamble Company Method of formulating a skin-lightening composition
WO2013184908A2 (en) 2012-06-06 2013-12-12 The Procter & Gamble Company Systems and methods for identifying cosmetic agents for hair/scalp care compositions
US9271912B2 (en) 2012-06-13 2016-03-01 The Procter & Gamble Company Personal care compositions comprising a pH tuneable gellant and methods of using
WO2014028569A1 (en) 2012-08-15 2014-02-20 The Procter & Gamble Company Systems, models and methods for identifying and evaluating skin-active agents effective for treating an array of skin disorders
WO2014028734A1 (en) 2012-08-15 2014-02-20 The Procter & Gamble Company Human ex vivo skin model and use in methods of identifying modulators of skin inflammation
MX352873B (es) 2013-03-13 2017-12-13 Unilever Nv Composiciones fotoprotectoras con triciclodecano amidas.
ITMI20130995A1 (it) * 2013-06-17 2014-12-18 Chemelectiva S R L Derivati dell'acido retinoico e processo per la loro preparazione
CN106715463B (zh) 2013-12-10 2020-10-16 苏塞克斯研究实验室 糖化肽组合物及其用途
US20160000682A1 (en) 2014-07-02 2016-01-07 Geoffrey Brooks Consultants Llc Peptide-Based Compositions and Methods of Use
WO2016173817A1 (en) 2015-04-28 2016-11-03 Unilever Plc N-aralkylcarbonyl-piperazine and -homopiperazine compounds and personal care compositions comprising the same
US10307355B2 (en) 2015-04-28 2019-06-04 Conopco, Inc. N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same
EP3373899B1 (de) 2015-11-10 2019-09-18 Unilever Plc. Körperpflegezusammensetzungen mit cyclocarbonsäure
EP3490524B1 (de) 2016-07-27 2021-10-13 Unilever IP Holdings B.V. Körperpflegezusammensetzungen mit fettsäureamidderivaten
US11083683B2 (en) 2016-10-28 2021-08-10 Coty Inc. Topical composition
PH12019501354B1 (en) 2016-12-21 2023-04-19 Unilever Ip Holdings B V Personal care compositions with cystine
EP3558243B1 (de) 2016-12-21 2022-10-05 Unilever IP Holdings B.V. Körperpflegezusammensetzungen mit schwerlöslichen verbindungen
WO2018154145A2 (en) * 2018-03-29 2018-08-30 Symrise Ag Compounds for skin improvement / treatment
GB201811312D0 (en) 2018-07-10 2018-08-29 Nuchido Ltd Compositions
US20230157939A1 (en) 2020-04-28 2023-05-25 Conopco, Inc., D/B/A Unilever Personal care compositions with enhanced solubility actives
WO2022008732A1 (en) 2020-07-10 2022-01-13 Basf Se Enhancing the activity of antimicrobial preservatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2917523A (en) * 1959-12-15 Production of compounds of the
US2424994A (en) * 1944-06-20 1947-08-05 Research Corp Vitamin a acid and its esters and method of making them
US2576103A (en) * 1946-12-24 1951-11-27 Eastman Kodak Co Synthesis of vitamin a active compounds containing repeated isoprene units
US2951853A (en) * 1957-06-08 1960-09-06 Sumitomo Chemical Co Method for preparing polyenecarboxylic acid derivatives
BE752927A (fr) * 1969-07-04 1971-01-04 Hoffmann La Roche Utilisation de composes polyeniques
ZA71145B (en) * 1970-02-02 1971-10-27 Hoffmann La Roche Use of vitamin a-acid
DE2050658A1 (en) * 1970-10-15 1972-05-25 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Vitamin a acid isopropyl ester - active against skin diseases
JPS5921863B2 (ja) * 1973-11-07 1984-05-22 日清製粉 （株） 新規なビタミンａ酸エステルの製造法
JPS5827266B2 (ja) * 1973-11-07 1983-06-08 ニツシンセイフン カブシキガイシヤ シンキナビタミン ａ サンエステル ノ セイゾウホウ
US3984544A (en) * 1975-02-28 1976-10-05 Schering Corporation Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
US4055659A (en) * 1975-11-03 1977-10-25 Johnson & Johnson Retinoic acid derivatives
US4216224A (en) * 1978-09-22 1980-08-05 Scott Eugene J Van Methods and compositions for treating psoriasis with retinoyl compounds
GB2097783B (en) * 1981-04-23 1984-12-12 Dermal Lab Ltd Imidazoles
US4529600A (en) * 1982-09-09 1985-07-16 Sri International Pentadeuterioretinoids
US4677120A (en) * 1985-07-31 1987-06-30 Molecular Design International Topical prodrugs for treatment of acne and skin diseases
DK498487A (da) * 1986-10-06 1988-04-07 Hoffmann La Roche Hidtil ukendte retinoider
DE3784738T2 (de) * 1987-06-12 1993-07-08 Molecular Design Int Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten.

Also Published As

Publication number Publication date
WO1989000157A1 (en) 1989-01-12
AU607097B2 (en) 1991-02-21
US4885311A (en) 1989-12-05
EP0366713A1 (de) 1990-05-09
DE3850109D1 (de) 1994-07-14
AU2080988A (en) 1989-01-30
EP0366713B1 (de) 1994-06-08
JPH03500643A (ja) 1991-02-14
DE3850109T2 (de) 1994-10-06

Similar Documents

Publication Publication Date Title
ATE106867T1 (de) 13-trans-retinsäureester.
NO940035D0 (no) Kolesterolester, samt anvendelse av slike estere
FI912703A7 (fi) Oleellinen rasvahappokäsittely
NL7904144A (nl) Vetzuurpreparaten ter behandeling en voorkomen van thrombo-embolie.
NO894296L (no) Fremgangsmaate for behandling av leddgikt og betennelsessykdommer.
KR920700634A (ko) 좌창 또는 건선 피부병을 치료하는 방법 및 여기에 사용되는 조성물
FI940874A7 (fi) Menetelmä maitohapon ja maitohappoestereiden valmistamiseksi
DK90888A (da) Maaleapparat til vaevsmetabolisme
IE871203L (en) Formulations containing unsaturated fatty acids
ITRM920761A0 (it) Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
NO885601D0 (no) Eventuelt kvataererte fettsyreestre av oxalkylerte alkyl-alkylendiaminer.
SE7902742L (sv) Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav
IT1098980B (it) Procedimento per la produzione di acidi carbossilici e/o di loro esteri
ATE84716T1 (de) 4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelialgewebekrankheiten.
IL83775A0 (en) Fumaramide derivatives and pharmaceutical compositions containing them for treating skin diseases
GB8710780D0 (en) Opthalmological application of eicosapentaenoic acid
IT7820979A0 (it) Acidi procedimento per la preparazione di di-alogenovinilciclopropan-carbossi lici e di loro esteri.
FI881959L (fi) Karboksyylihappoestereiden pelkistys
IT8721115A0 (it) Fitopreparato per la cura di affezioni cutanee.
GR3006674T3 (de)
DE3784738D1 (de) Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten.
SE8102161L (sv) "3,7,11,15-tetrametyl-2,4,6,10,14-hexadekapentaensyra
IT8847622A0 (it) Zi procedimento ed apparecchio per il trattamento elettrochimico di pez-
GR75239B (de)
ES2063056T3 (es) Esteres poliaromaticos de antibioticos macrolidicos y lincosamidicos, su procedimiento de preparacion y composiciones farmaceuticas y cosmeticas que los contienen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee