ATE107287T1 - 1-acyl-2,3-dihydro-4(1h)-chinolon-4-oxim- derivate, verfahren zu ihrer herstellung und verwendung davon. - Google Patents
1-acyl-2,3-dihydro-4(1h)-chinolon-4-oxim- derivate, verfahren zu ihrer herstellung und verwendung davon.Info
- Publication number
- ATE107287T1 ATE107287T1 AT88118167T AT88118167T ATE107287T1 AT E107287 T1 ATE107287 T1 AT E107287T1 AT 88118167 T AT88118167 T AT 88118167T AT 88118167 T AT88118167 T AT 88118167T AT E107287 T1 ATE107287 T1 AT E107287T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- dihydro
- acyl
- present
- oxime
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 206010003445 Ascites Diseases 0.000 abstract 2
- 230000001882 diuretic effect Effects 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000004880 Polyuria Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62276474A JP2602037B2 (ja) | 1987-10-31 | 1987-10-31 | １−アシル−２，３−ジヒドロ−４（１ｈ）−キノリノン−４−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE107287T1 true ATE107287T1 (de) | 1994-07-15 |
Family
ID=17569953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88118167T ATE107287T1 (de) | 1987-10-31 | 1988-10-31 | 1-acyl-2,3-dihydro-4(1h)-chinolon-4-oxim- derivate, verfahren zu ihrer herstellung und verwendung davon. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4968680A (de) |
| EP (1) | EP0315115B1 (de) |
| JP (1) | JP2602037B2 (de) |
| AT (1) | ATE107287T1 (de) |
| AU (1) | AU612422B2 (de) |
| CA (1) | CA1339663C (de) |
| DE (1) | DE3850215T2 (de) |
| ES (1) | ES2056873T3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW234124B (de) * | 1992-07-15 | 1994-11-11 | Sumitomo Chemical Co | |
| US7553967B2 (en) * | 2004-03-12 | 2009-06-30 | Wyeth | 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4013662A (en) * | 1974-12-19 | 1977-03-22 | Pfizer Inc. | Alkyl and benzyl 6,7-dialkoxy-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylates |
| US3976650A (en) * | 1975-11-04 | 1976-08-24 | Pfizer Inc. | Process for preparing optically active 6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid ester analgesics |
| US4260764A (en) * | 1976-12-22 | 1981-04-07 | Pfizer Inc. | 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefor |
| US4421919A (en) * | 1980-07-28 | 1983-12-20 | Hodogaya Chemical Co., Ltd. | 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives |
| US4440770A (en) * | 1980-07-28 | 1984-04-03 | Mochida Seiyaku Kabushiki Kaisha | Diuretic, hypotensive and antiedemic quinoline oximes |
| GB2081091B (en) * | 1980-07-28 | 1984-03-07 | Mochida Pharm Co Ltd | Hypotensive diuretic pharmaceutical compositions containing tetrahydroquinoline derivatives |
| GB2092130B (en) * | 1980-07-28 | 1984-05-10 | Hodogaya Chemical Co Ltd | 4-oximino-1,2,3,4-tetrahydroquinoline derivatives |
| US4521607A (en) * | 1981-02-27 | 1985-06-04 | Takeda Chemical Industries, Ltd. | Chromanyl glycines |
| DE3416695A1 (de) * | 1984-05-05 | 1985-11-07 | Bayer Ag, 5090 Leverkusen | Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| PH21213A (en) * | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
| DE3660255D1 (en) * | 1985-04-12 | 1988-07-07 | Ciba Geigy Ag | Oxime sulphonates containing reactive groups |
| US4839368A (en) * | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
| JPH0446951A (ja) * | 1990-06-14 | 1992-02-17 | Matsushita Electric Works Ltd | フエノール樹脂成形材料 |
-
1987
- 1987-10-31 JP JP62276474A patent/JP2602037B2/ja not_active Expired - Lifetime
-
1988
- 1988-10-28 CA CA000581642A patent/CA1339663C/en not_active Expired - Fee Related
- 1988-10-28 US US07/264,017 patent/US4968680A/en not_active Expired - Fee Related
- 1988-10-31 ES ES88118167T patent/ES2056873T3/es not_active Expired - Lifetime
- 1988-10-31 AT AT88118167T patent/ATE107287T1/de active
- 1988-10-31 EP EP88118167A patent/EP0315115B1/de not_active Expired - Lifetime
- 1988-10-31 AU AU24549/88A patent/AU612422B2/en not_active Ceased
- 1988-10-31 DE DE3850215T patent/DE3850215T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0315115B1 (de) | 1994-06-15 |
| US4968680A (en) | 1990-11-06 |
| ES2056873T3 (es) | 1994-10-16 |
| CA1339663C (en) | 1998-02-10 |
| DE3850215D1 (de) | 1994-07-21 |
| AU2454988A (en) | 1989-05-04 |
| DE3850215T2 (de) | 1994-11-24 |
| JP2602037B2 (ja) | 1997-04-23 |
| EP0315115A2 (de) | 1989-05-10 |
| AU612422B2 (en) | 1991-07-11 |
| EP0315115A3 (de) | 1991-02-27 |
| JPH01121269A (ja) | 1989-05-12 |
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