ATE107629T1 - Tetrahydronaphthalenderivate und verfahren zu ihrer herstellung. - Google Patents
Tetrahydronaphthalenderivate und verfahren zu ihrer herstellung.Info
- Publication number
- ATE107629T1 ATE107629T1 AT90312155T AT90312155T ATE107629T1 AT E107629 T1 ATE107629 T1 AT E107629T1 AT 90312155 T AT90312155 T AT 90312155T AT 90312155 T AT90312155 T AT 90312155T AT E107629 T1 ATE107629 T1 AT E107629T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- lower alkyl
- alkyl group
- carboxy
- chem
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000005189 Embolism Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 carboxy-phenyl group Chemical group 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000002464 muscle smooth vascular Anatomy 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29787889 | 1989-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE107629T1 true ATE107629T1 (de) | 1994-07-15 |
Family
ID=17852288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90312155T ATE107629T1 (de) | 1989-11-16 | 1990-11-06 | Tetrahydronaphthalenderivate und verfahren zu ihrer herstellung. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5206428A (de) |
| EP (1) | EP0430459B1 (de) |
| JP (1) | JPH0649677B2 (de) |
| KR (1) | KR910009649A (de) |
| CN (1) | CN1023938C (de) |
| AT (1) | ATE107629T1 (de) |
| AU (1) | AU631023B2 (de) |
| CA (1) | CA2030004A1 (de) |
| DE (1) | DE69010158T2 (de) |
| DK (1) | DK0430459T3 (de) |
| ES (1) | ES2058817T3 (de) |
| FI (1) | FI95368C (de) |
| HU (1) | HUT56340A (de) |
| IE (1) | IE64515B1 (de) |
| IL (1) | IL96198A0 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206428A (en) * | 1989-11-16 | 1993-04-27 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthalene derivatives and preparation thereof |
| EP0499755A1 (de) * | 1991-02-18 | 1992-08-26 | MIDY S.p.A. | Phenylethanolaminotetraline, Verfahren zu deren Herstellung, Zwischenprodukte davon und diese enthaltende pharmazeutische Zusammensetzungen |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicyclic compounds and pharmaceutical compositions containing them |
| US6448269B1 (en) | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| US6137002A (en) | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| FR2711139B1 (fr) * | 1993-10-15 | 1995-12-01 | Adir | Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US6653331B2 (en) * | 1996-07-03 | 2003-11-25 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
| EP1667958A2 (de) | 2003-10-01 | 2006-06-14 | The Procter & Gamble Company | Antagonisten des melaninkonzentrierenden hormons |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623941A1 (de) * | 1986-07-16 | 1988-01-28 | Bayer Ag | Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel |
| DE3623944A1 (de) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3642105A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte aminomethyl-5,6,7,8-tetrahydronaphtyl-oxyessigsaeuren, neue zwischenprodukte, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| IL88314A (en) * | 1987-11-18 | 1994-05-30 | Tanabe Seiyaku Co | Sulphonylamino indane derivatives, their preparation and pharmaceutical compositions containing them |
| JPH02231464A (ja) * | 1988-02-26 | 1990-09-13 | Tanabe Seiyaku Co Ltd | インダンオキシ酢酸誘導体 |
| US5206428A (en) * | 1989-11-16 | 1993-04-27 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthalene derivatives and preparation thereof |
-
1990
- 1990-10-30 US US07/605,433 patent/US5206428A/en not_active Expired - Fee Related
- 1990-10-31 IL IL96198A patent/IL96198A0/xx unknown
- 1990-11-02 AU AU65727/90A patent/AU631023B2/en not_active Ceased
- 1990-11-06 DE DE69010158T patent/DE69010158T2/de not_active Expired - Fee Related
- 1990-11-06 DK DK90312155.6T patent/DK0430459T3/da active
- 1990-11-06 AT AT90312155T patent/ATE107629T1/de not_active IP Right Cessation
- 1990-11-06 EP EP90312155A patent/EP0430459B1/de not_active Expired - Lifetime
- 1990-11-06 ES ES90312155T patent/ES2058817T3/es not_active Expired - Lifetime
- 1990-11-14 CA CA002030004A patent/CA2030004A1/en not_active Abandoned
- 1990-11-15 IE IE413390A patent/IE64515B1/en not_active IP Right Cessation
- 1990-11-15 JP JP2310926A patent/JPH0649677B2/ja not_active Expired - Lifetime
- 1990-11-15 FI FI905655A patent/FI95368C/fi not_active IP Right Cessation
- 1990-11-16 KR KR1019900018603A patent/KR910009649A/ko not_active Ceased
- 1990-11-16 CN CN90109301A patent/CN1023938C/zh not_active Expired - Fee Related
- 1990-11-16 HU HU907177A patent/HUT56340A/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0430459A1 (de) | 1991-06-05 |
| IE904133A1 (en) | 1991-05-22 |
| AU631023B2 (en) | 1992-11-12 |
| AU6572790A (en) | 1991-06-20 |
| CN1023938C (zh) | 1994-03-09 |
| FI905655A0 (fi) | 1990-11-15 |
| HUT56340A (en) | 1991-08-28 |
| JPH03218346A (ja) | 1991-09-25 |
| IL96198A0 (en) | 1991-07-18 |
| CA2030004A1 (en) | 1991-05-17 |
| ES2058817T3 (es) | 1994-11-01 |
| DK0430459T3 (da) | 1994-07-25 |
| JPH0649677B2 (ja) | 1994-06-29 |
| KR910009649A (ko) | 1991-06-28 |
| DE69010158T2 (de) | 1994-10-06 |
| FI95368B (fi) | 1995-10-13 |
| FI95368C (fi) | 1996-01-25 |
| FI905655A7 (fi) | 1991-05-17 |
| HU907177D0 (en) | 1991-05-28 |
| IE64515B1 (en) | 1995-08-09 |
| CN1052112A (zh) | 1991-06-12 |
| DE69010158D1 (de) | 1994-07-28 |
| EP0430459B1 (de) | 1994-06-22 |
| US5206428A (en) | 1993-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |