PT89992A - Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina - Google Patents

Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina

Info

Publication number: PT89992A
Authority: PT; Portugal
Prior art keywords: preparation; isomers; tetrahydroisotiazole; pyridine; derivatives
Prior art date: 1988-03-14

Application number

PT89992A

Other languages

English (en)

Other versions

PT89992B (pt

Inventor

Henrik Pedersen

Porl Krogsgaard-Larsen

Erik Falch

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-14

Filing date

1989-03-13

Publication date

1989-11-10

1988-03-14 Priority claimed from GB888806013A external-priority patent/GB8806013D0/en

1988-09-26 Priority claimed from GB888822564A external-priority patent/GB8822564D0/en

1989-03-13 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1989-11-10 Publication of PT89992A publication Critical patent/PT89992A/pt

1994-05-31 Publication of PT89992B publication Critical patent/PT89992B/pt

Links

238000000034 method Methods 0.000 title abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
229960004373 acetylcholine Drugs 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001270 agonistic effect Effects 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT89992A 1988-03-14 1989-03-13 Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina PT89992B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888806013A GB8806013D0 (en)	1988-03-14	1988-03-14	Heterocyclic compounds
GB888822564A GB8822564D0 (en)	1988-09-26	1988-09-26	Heterocyclic compounds

Publications (2)

Publication Number	Publication Date
PT89992A true PT89992A (pt)	1989-11-10
PT89992B PT89992B (pt)	1994-05-31

Family

ID=26293631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89992A PT89992B (pt)	1988-03-14	1989-03-13	Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina

Country Status (17)

Country	Link
US (1)	US4923880A (pt)
EP (1)	EP0336555B1 (pt)
JP (1)	JPH01275585A (pt)
AT (1)	ATE81130T1 (pt)
AU (1)	AU630085B2 (pt)
CA (1)	CA1337201C (pt)
DE (1)	DE68903019T2 (pt)
DK (1)	DK169676B1 (pt)
ES (1)	ES2052901T3 (pt)
FI (1)	FI91411C (pt)
GR (1)	GR3006606T3 (pt)
IE (1)	IE62782B1 (pt)
IL (1)	IL89351A0 (pt)
NO (1)	NO177145C (pt)
NZ (1)	NZ228182A (pt)
PT (1)	PT89992B (pt)
ZA (1)	ZA891769B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2645862B1 (fr) *	1989-04-18	1991-07-12	Esteve Labor Dr	Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
US5574028A (en) *	1994-10-31	1996-11-12	Eli Lilly And Company	Method for treating anxiety
NZ324988A (en) *	1995-12-07	1999-08-30	Lilly Co Eli	Composition for treating pain comprising a selected muscarinic compound and an analgesic or nsaid
US20050137222A1 (en) *	2003-12-18	2005-06-23	H. Lundbeck A/S	Treatment of insomnia in human patients
US20110098777A1 (en) *	2009-10-23	2011-04-28	Silverstone Leon M	Method and apparatus for treatment of neurodegenerative diseases including depression, mild cognitive impairment, and dementia
DK3274331T3 (da)	2015-03-24	2020-03-23	H Lundbeck As	Fremstilling af 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol
AU2024259614A1 (en)	2023-04-18	2025-10-02	Vanderbilt University	Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4
EP4698539A1 (en) *	2023-04-18	2026-02-25	Vanderbilt University	Pyrrolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8314391D0 (en) *	1983-05-24	1983-06-29	Kefalas As	Heterocyclic compounds
IL87709A (en) *	1987-09-16	1992-11-15	Pfizer	Process for preparing haloalkyl thiazoles and some such novel haloalkyl thiazoles
DE3820775A1 (de) *	1988-06-20	1989-12-21	Thomae Gmbh Dr K	Neue 4,5,7,8-tetrahydro-6h-thiazolo(5,4,-d)azepine, ihre herstellung und ihre verwendung als arzneimittel
JP3054738B2 (ja) *	1988-07-22	2000-06-19	武田薬品工業株式会社	チアゾロ［５，４―ｂ］アゼピン誘導体

1989
- 1989-02-21 IL IL89351A patent/IL89351A0/xx not_active IP Right Cessation
- 1989-02-28 IE IE64889A patent/IE62782B1/en not_active IP Right Cessation
- 1989-02-28 AT AT89301996T patent/ATE81130T1/de not_active IP Right Cessation
- 1989-02-28 ES ES89301996T patent/ES2052901T3/es not_active Expired - Lifetime
- 1989-02-28 EP EP89301996A patent/EP0336555B1/en not_active Expired - Lifetime
- 1989-02-28 DE DE8989301996T patent/DE68903019T2/de not_active Expired - Fee Related
- 1989-03-01 NZ NZ228182A patent/NZ228182A/xx unknown
- 1989-03-08 ZA ZA891769A patent/ZA891769B/xx unknown
- 1989-03-10 FI FI891155A patent/FI91411C/fi not_active IP Right Cessation
- 1989-03-13 CA CA000593449A patent/CA1337201C/en not_active Expired - Fee Related
- 1989-03-13 NO NO891071A patent/NO177145C/no unknown
- 1989-03-13 PT PT89992A patent/PT89992B/pt not_active IP Right Cessation
- 1989-03-13 US US07/322,632 patent/US4923880A/en not_active Expired - Fee Related
- 1989-03-14 JP JP1059860A patent/JPH01275585A/ja active Pending
- 1989-03-14 AU AU31262/89A patent/AU630085B2/en not_active Ceased
- 1989-03-14 DK DK121789A patent/DK169676B1/da active
1992
- 1992-12-21 GR GR920403014T patent/GR3006606T3/el unknown

Also Published As

Publication number	Publication date
NZ228182A (en)	1990-08-28
FI891155A0 (fi)	1989-03-10
IE62782B1 (en)	1995-02-22
DE68903019T2 (de)	1993-07-08
JPH01275585A (ja)	1989-11-06
NO177145C (no)	1995-07-26
EP0336555A1 (en)	1989-10-11
AU3126289A (en)	1989-09-14
ATE81130T1 (de)	1992-10-15
NO891071L (no)	1989-09-15
FI891155A7 (fi)	1989-09-15
EP0336555B1 (en)	1992-09-30
DE68903019D1 (de)	1992-11-05
AU630085B2 (en)	1992-10-22
CA1337201C (en)	1995-10-03
NO891071D0 (no)	1989-03-13
DK169676B1 (da)	1995-01-09
NO177145B (no)	1995-04-18
PT89992B (pt)	1994-05-31
IE890648L (en)	1989-09-14
IL89351A0 (en)	1989-09-10
FI91411B (fi)	1994-03-15
ES2052901T3 (es)	1994-07-16
GR3006606T3 (pt)	1993-06-30
DK121789D0 (da)	1989-03-14
US4923880A (en)	1990-05-08
DK121789A (da)	1989-09-15
ZA891769B (en)	1989-12-27
FI91411C (fi)	1994-06-27

Legal Events

Date

Code

Title

Description

1994-05-31

FG3A

Patent granted, date of granting

Effective date: 19931118

1999-09-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990531

Publication	Publication Date	Title
ATE71375T1 (de)	1992-01-15	Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
ES2071725T3 (es)	1995-07-01	Diesteres fosfato de acido ascorbico y tocoferilo para la inhibicion de la reaccion de maillard.
HUT47217A (en)	1989-02-28	Process for producing pharmaceutical compositions containing indol derivatives as active components
EP0495982A4 (en)	1994-07-20	Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient
FR2695387B1 (fr)	1994-10-21	Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ATE119885T1 (de)	1995-04-15	1,2,3,4-tetrahydro-9-akridinaminderivate.
MX13270A (es)	1993-06-01	Procedimiento para la preparacion de derivados de 4-aminopiridina
KR100271416B1 (en)	2000-11-15	Carbamate derivatives of 4-amino-3-isoxazolidinones,3-amino-1-hydroxypyrrolidin-2-ones and1-amino-1-cyclopropanecarboxylic acid analogs, aprocess for their preparation and a pharmaceuticalcomposition comprising the same
ATE55981T1 (de)	1990-09-15	Phenylserin-derivate und verfahren zu ihrer herstellung.
FI891155A0 (fi)	1989-03-10	Menetelmä terapeuttisesti käyttökelpoisten 4,5,6,7-tetrahydroisotiatsolo/4,5-c/pyridiini-johdannaisten ja niiden isomeerien ja happoadditiosuolojen valmistamiseksi
NZ232207A (en)	1991-08-27	Dihydrobenz(c)acridine derivatives and pharmaceutical compositions
NO169391C (no)	1992-06-17	Analogifremgangsmaate for fremstilling av et terapeutisk aktivt (-)-cis-quinuklidin og syreaddisjonssalter derav
BR9601989A (pt)	1998-04-07	Indenoilguanidinas processo para sua preparação seus usos e medicamento
HU9401968D0 (en)	1994-09-28	Pharmaceutical compositions and process for producing them
FI915646A0 (fi)	1991-11-29	Menetelmä terapeuttisesti käyttökelpoisten 4,5,6,11-tetrahydrobentso[6,7]syklo-okta[1,2-b]tiofeeni-6,11-imiinien ja 6,11-dihydrobentso[6,7]syklo-okta[1,2-b]tiofeeni-6,11-imiinien valmistamiseksi ja siinä käyttökelpoinen välituoteyhdiste