ATE107634T1 - L-glutamsäure-derivate. - Google Patents

L-glutamsäure-derivate.

Info

Publication number: ATE107634T1
Authority: AT; Austria
Prior art keywords: glutamic acid; acid derivatives; derivatives; hydroxypyrimidin; pyrimidin
Prior art date: 1988-01-19

Application number

AT89300045T

Other languages

English (en)

Inventor

Edward C Taylor

Philip M Harrington

Chuan Shih

Original Assignee

Univ Princeton

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-19

Filing date

1989-01-05

Publication date

1994-07-15

1989-01-05 Application filed by Univ Princeton, Lilly Co Eli filed Critical Univ Princeton

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE107634T1 publication Critical patent/ATE107634T1/de

Links

150000008539 L-glutamic acids Chemical class 0.000 title 1
LNUHUIPUTGDPDG-AWEZNQCLSA-N (2s)-2-[[4-[4-(2,6-diamino-4-oxo-1h-pyrimidin-5-yl)butyl]benzoyl]amino]pentanedioic acid Chemical group N1C(N)=NC(=O)C(CCCCC=2C=CC(=CC=2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=C1N LNUHUIPUTGDPDG-AWEZNQCLSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-Glutamic acid Natural products OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229960002989 glutamic acid Drugs 0.000 abstract 1
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT89300045T 1988-01-19 1989-01-05 L-glutamsäure-derivate. ATE107634T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/144,970 US4871743A (en)	1988-01-19	1988-01-19	L-glutamic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE107634T1 true ATE107634T1 (de)	1994-07-15

Family

ID=22511004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89300045T ATE107634T1 (de)	1988-01-19	1989-01-05	L-glutamsäure-derivate.

Country Status (7)

Country	Link
US (1)	US4871743A (de)
EP (1)	EP0325343B1 (de)
JP (1)	JP2679737B2 (de)
AT (1)	ATE107634T1 (de)
CA (1)	CA1314547C (de)
DE (1)	DE68916268T2 (de)
ES (1)	ES2055024T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5019577A (en) *	1988-04-15	1991-05-28	Burroughs Welcome Co.	Novel compounds and use
US4971973A (en) *	1989-05-17	1990-11-20	Burroughs Wellcome Co.	Glutamic acid derivatives
JP2983254B2 (ja) *	1989-06-14	1999-11-29	武田薬品工業株式会社	ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
US4920125A (en) *	1989-08-29	1990-04-24	The Trustees Of Princeton University	L-glutamic acid derivatives
US4996206A (en) *	1989-12-11	1991-02-26	The Trustees Of Princeton University	N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US5013738A (en) *	1990-04-18	1991-05-07	The Trustees Of Princeton University	L-glutamic acid derivatives
US5045988A (en) *	1990-07-31	1991-09-03	Eaton Corporation	Isolated adjustable frequency AC inverter control
US5217974A (en) *	1991-03-29	1993-06-08	Eli Lilly And Company	Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
PT674516E (pt) *	1992-12-16	2000-05-31	Agouron Pharma	Compostos de 5-tiapirimidinona e 5-selenopirimidinona substituidos antiproliferativos
US5945427A (en) *	1995-06-07	1999-08-31	Agouron Pharmaceuticals, Inc.	Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5594139A (en) *	1993-01-29	1997-01-14	Agouron Pharmaceuticals, Inc.	Processes for preparing antiproliferative garft-inhibiting compounds
US5426110A (en) *	1993-10-06	1995-06-20	Eli Lilly And Company	Pyrimidinyl-glutamic acid derivatives
US5831100A (en) *	1995-06-07	1998-11-03	Agouron Pharmaceuticals, Inc.	Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
JP2002509881A (ja) *	1998-03-27	2002-04-02	ジェネンテク・インコーポレイテッド	Ｃｄ１１／ｃｄ１８接着レセプター媒介疾患の治療用アンタゴニスト
JP2005528397A (ja) *	2002-04-05	2005-09-22	ザスクリプスリサーチインスティテュート	グリシンアミドリボヌクレオチドトランスホルミラーゼの阻害剤
EP1699777B1 (de) *	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Dipeptidylpeptidase-hemmer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4515948A (en) *	1973-09-12	1985-05-07	Hoffmann-La Roche Inc.	2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines

1988
- 1988-01-19 US US07/144,970 patent/US4871743A/en not_active Expired - Fee Related
1989
- 1989-01-05 ES ES89300045T patent/ES2055024T3/es not_active Expired - Lifetime
- 1989-01-05 AT AT89300045T patent/ATE107634T1/de not_active IP Right Cessation
- 1989-01-05 EP EP89300045A patent/EP0325343B1/de not_active Expired - Lifetime
- 1989-01-05 DE DE68916268T patent/DE68916268T2/de not_active Expired - Fee Related
- 1989-01-12 CA CA000588039A patent/CA1314547C/en not_active Expired - Fee Related
- 1989-01-19 JP JP1010979A patent/JP2679737B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0325343A2 (de)	1989-07-26
JP2679737B2 (ja)	1997-11-19
ES2055024T3 (es)	1994-08-16
CA1314547C (en)	1993-03-16
DE68916268D1 (de)	1994-07-28
JPH02781A (ja)	1990-01-05
DE68916268T2 (de)	1994-10-13
US4871743A (en)	1989-10-03
EP0325343A3 (en)	1990-09-05
EP0325343B1 (de)	1994-06-22

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
1998-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68916268D1 (de)	1994-07-28	L-Glutamsäure-Derivate.
DE68929111D1 (de)	2000-01-13	Verwendung von Halogenkohlenwasserstofflösungsmitteln
DK0422937T3 (da)	1994-03-28	Fibrinogenreceptorantagonister
FI955828A0 (fi)	1995-12-04	Uusia peptidijohdannaisia
FI930970A0 (fi)	1993-03-04	Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa
ATE199545T1 (de)	2001-03-15	Inhibitoren retroviraler proteasen
NO932607D0 (no)	1993-07-19	Piperidinderivater og anvendelse av disse
DE69527072D1 (de)	2002-07-18	Endothelin antagoniste
FI911980A0 (fi)	1991-04-24	N-(3-fluor-2-fosfonylmetoxipropyl) -derivat av heterocykliska purin- och pyrimidinbaser, deras framstaellning och anvaendning.
NO944406D0 (no)	1994-11-17	Nye 7 se inhibitorer
ES2061962T3 (es)	1994-12-16	Derivados de pirido (2,3-d) pirimidina.
DE69013750D1 (de)	1994-12-08	Antagonisten von excitatorischen Aminosäuren.
DE59509395D1 (de)	2001-08-16	Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
NO901652D0 (no)	1990-04-11	Angstdempende midler.
DE3561153D1 (de)	1988-01-21	Benzoylurea derivatives
ATE138655T1 (de)	1996-06-15	L-glutamsäure-derivate
FI962768A0 (fi)	1996-07-05	N-(2-ftaali-imidoetyyli)substituoituja transpiperidiini-2,5-dikarboksylaatteja
ATE50257T1 (de)	1990-02-15	Kristalline form von benzothiazindioxydsalz.
DK661388D0 (da)	1988-11-25	Fremgangsmaade til fremstilling af thiophenforbindelser
ATE100710T1 (de)	1994-02-15	Eperisone als hypotonikum.
DE68914950D1 (de)	1994-06-01	Aminsalze von 1,4,2-Oxazaphospholidin-2-alkoxy-2-oxid-4-essigsäuren.
DE58909089D1 (de)	1995-04-13	Verwendung von Myricetin-3-0-beta-D-glucuronid als Arzneimittel.