ATE107634T1 - L-glutamsäure-derivate. - Google Patents
L-glutamsäure-derivate.Info
- Publication number
- ATE107634T1 ATE107634T1 AT89300045T AT89300045T ATE107634T1 AT E107634 T1 ATE107634 T1 AT E107634T1 AT 89300045 T AT89300045 T AT 89300045T AT 89300045 T AT89300045 T AT 89300045T AT E107634 T1 ATE107634 T1 AT E107634T1
- Authority
- AT
- Austria
- Prior art keywords
- glutamic acid
- acid derivatives
- derivatives
- hydroxypyrimidin
- pyrimidin
- Prior art date
Links
- 150000008539 L-glutamic acids Chemical class 0.000 title 1
- LNUHUIPUTGDPDG-AWEZNQCLSA-N (2s)-2-[[4-[4-(2,6-diamino-4-oxo-1h-pyrimidin-5-yl)butyl]benzoyl]amino]pentanedioic acid Chemical group N1C(N)=NC(=O)C(CCCCC=2C=CC(=CC=2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=C1N LNUHUIPUTGDPDG-AWEZNQCLSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-Glutamic acid Natural products OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/144,970 US4871743A (en) | 1988-01-19 | 1988-01-19 | L-glutamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE107634T1 true ATE107634T1 (de) | 1994-07-15 |
Family
ID=22511004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89300045T ATE107634T1 (de) | 1988-01-19 | 1989-01-05 | L-glutamsäure-derivate. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4871743A (de) |
| EP (1) | EP0325343B1 (de) |
| JP (1) | JP2679737B2 (de) |
| AT (1) | ATE107634T1 (de) |
| CA (1) | CA1314547C (de) |
| DE (1) | DE68916268T2 (de) |
| ES (1) | ES2055024T3 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019577A (en) * | 1988-04-15 | 1991-05-28 | Burroughs Welcome Co. | Novel compounds and use |
| US4971973A (en) * | 1989-05-17 | 1990-11-20 | Burroughs Wellcome Co. | Glutamic acid derivatives |
| JP2983254B2 (ja) * | 1989-06-14 | 1999-11-29 | 武田薬品工業株式会社 | ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体 |
| US4920125A (en) * | 1989-08-29 | 1990-04-24 | The Trustees Of Princeton University | L-glutamic acid derivatives |
| US5028608A (en) * | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
| US5013738A (en) * | 1990-04-18 | 1991-05-07 | The Trustees Of Princeton University | L-glutamic acid derivatives |
| US5045988A (en) * | 1990-07-31 | 1991-09-03 | Eaton Corporation | Isolated adjustable frequency AC inverter control |
| US5217974A (en) * | 1991-03-29 | 1993-06-08 | Eli Lilly And Company | Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity |
| JPH08504765A (ja) * | 1992-12-16 | 1996-05-21 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | 抗増殖性の置換５−チアピリミジノンおよび５−セレノピリミジノン化合物 |
| US5945427A (en) * | 1995-06-07 | 1999-08-31 | Agouron Pharmaceuticals, Inc. | Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds |
| US5594139A (en) * | 1993-01-29 | 1997-01-14 | Agouron Pharmaceuticals, Inc. | Processes for preparing antiproliferative garft-inhibiting compounds |
| US5426110A (en) * | 1993-10-06 | 1995-06-20 | Eli Lilly And Company | Pyrimidinyl-glutamic acid derivatives |
| US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
| CA2325986A1 (en) * | 1998-03-27 | 1999-10-07 | Genentech, Inc. | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| WO2003087065A1 (en) * | 2002-04-05 | 2003-10-23 | The Scripps Research Institute | Inhibitors of glycinamide ribonucleotide transformylase |
| WO2005026148A1 (en) * | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
-
1988
- 1988-01-19 US US07/144,970 patent/US4871743A/en not_active Expired - Fee Related
-
1989
- 1989-01-05 DE DE68916268T patent/DE68916268T2/de not_active Expired - Fee Related
- 1989-01-05 ES ES89300045T patent/ES2055024T3/es not_active Expired - Lifetime
- 1989-01-05 EP EP89300045A patent/EP0325343B1/de not_active Expired - Lifetime
- 1989-01-05 AT AT89300045T patent/ATE107634T1/de not_active IP Right Cessation
- 1989-01-12 CA CA000588039A patent/CA1314547C/en not_active Expired - Fee Related
- 1989-01-19 JP JP1010979A patent/JP2679737B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE68916268D1 (de) | 1994-07-28 |
| JP2679737B2 (ja) | 1997-11-19 |
| CA1314547C (en) | 1993-03-16 |
| EP0325343A3 (en) | 1990-09-05 |
| US4871743A (en) | 1989-10-03 |
| DE68916268T2 (de) | 1994-10-13 |
| JPH02781A (ja) | 1990-01-05 |
| EP0325343A2 (de) | 1989-07-26 |
| ES2055024T3 (es) | 1994-08-16 |
| EP0325343B1 (de) | 1994-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |