ATE98243T1 - Pyrido(2,3-d>pyrimidinderivate. - Google Patents

Pyrido(2,3-d>pyrimidinderivate.

Info

Publication number
ATE98243T1
ATE98243T1 AT89300046T AT89300046T ATE98243T1 AT E98243 T1 ATE98243 T1 AT E98243T1 AT 89300046 T AT89300046 T AT 89300046T AT 89300046 T AT89300046 T AT 89300046T AT E98243 T1 ATE98243 T1 AT E98243T1
Authority
AT
Austria
Prior art keywords
derivatives
pyrimidi
pyrido
tetrahydropyrido
benzoyl
Prior art date
Application number
AT89300046T
Other languages
English (en)
Inventor
Edward C Taylor
Chuan Shih
Original Assignee
Univ Princeton
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton, Lilly Co Eli filed Critical Univ Princeton
Application granted granted Critical
Publication of ATE98243T1 publication Critical patent/ATE98243T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT89300046T 1988-02-05 1989-01-05 Pyrido(2,3-d>pyrimidinderivate. ATE98243T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/156,908 US4889859A (en) 1988-02-05 1988-02-05 Pyrido[2,3-d]pyrimidine derivatives
EP89300046A EP0327190B1 (de) 1988-02-05 1989-01-05 Pyrido[2,3-d]pyrimidinderivate

Publications (1)

Publication Number Publication Date
ATE98243T1 true ATE98243T1 (de) 1993-12-15

Family

ID=22561620

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89300046T ATE98243T1 (de) 1988-02-05 1989-01-05 Pyrido(2,3-d>pyrimidinderivate.

Country Status (7)

Country Link
US (1) US4889859A (de)
EP (1) EP0327190B1 (de)
JP (1) JP2848839B2 (de)
AT (1) ATE98243T1 (de)
CA (1) CA1340792C (de)
DE (1) DE68911159T2 (de)
ES (1) ES2061962T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins
US5030634A (en) * 1990-03-29 1991-07-09 Krumdieck Carlos L 10-deazaaminopterin: a new arthritis remittive drug
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
DE69618875D1 (de) * 1995-09-08 2002-03-14 Univ Princeton Nicht-klassische Antifolate
WO1997049705A1 (en) * 1996-06-25 1997-12-31 The Trustees Of Princeton University 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN114478345B (zh) * 2022-02-10 2024-06-14 中瀚(齐河县)生物医药科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60307A (en) * 1979-06-14 1984-02-29 Wellcome Found 2,4-diamino-6-(dimethoxybenzyl)-5-methylpyrido-(2,3-d)pyrimidines,their preparation and pharmaceutical compositions containing them
US4460591A (en) 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0327190B1 (de) 1993-12-08
EP0327190A1 (de) 1989-08-09
US4889859A (en) 1989-12-26
JP2848839B2 (ja) 1999-01-20
DE68911159D1 (de) 1994-01-20
DE68911159T2 (de) 1994-04-07
JPH01226886A (ja) 1989-09-11
ES2061962T3 (es) 1994-12-16
CA1340792C (en) 1999-10-19

Similar Documents

Publication Publication Date Title
ATE98243T1 (de) Pyrido(2,3-d>pyrimidinderivate.
CA2031890A1 (en) N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
FI914928A0 (fi) Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
FI955828A0 (fi) Uusia peptidijohdannaisia
DK472186D0 (da) Pyrido (2,3-d) pyrimidin derivater
DK232989D0 (da) Antiviralt praeparat
ATE172975T1 (de) Benzimidezolderivate mit antidiabetischer und anti-plättchenklumpungswirkung
EP0325343A3 (en) L-glutamic acid derivatives
AU1835988A (en) New derivatives of substituted pyridine-3-carboxylic acid and use thereof
FI893426A0 (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten BU-3608-johdannaisten ja niiden suolojen valmistamiseksi
ES2003828A6 (es) Mejoras introducidas en el objeto de la patente principal n 552684 por un procedimiento para la obtencion de derivados 4 1 (5,6,7,8-tetrahidropirido(2,3-d)pirimidin-6-il-alquil-2 benzoil de acido l-glutamico
EP0378824A3 (en) Use of omega-3-fatty acids as anticachexia agents
ATE138655T1 (de) L-glutamsäure-derivate
ES2113851T3 (es) Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato.
ES476837A1 (es) Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno.
IL86752A (en) Thiophene derivatives and their preparation and their use as intermediates in the preparation of n-(2,4-dimethylthien-3-yl) -n-(1-methoxyprop-2-yl) - chloroacetamide
ES2093051T3 (es) Purinil- y pirimidil-tetrahidrofuranos.
ATE100710T1 (de) Eperisone als hypotonikum.
FI882388A0 (fi) 4-substituerad 10-cyanmetylenpyrrolo /4,3-e/benzoazepin.
DK92787D0 (da) 3-(1h-tetrazol-5-yl)thienooe2,3-daapyrimidin-4(3h)-oner samt fremstilling deraf
BR1101036A (pt) Derivados de n-(pirrolo(2,3-d)pirimidin-3-ilacil)-ácido glutâmico
BR1101026A (pt) Derivados de ácido n-(5,6,7,8-tetraidropirido[2,3-d]pirimidin-6-iletil-tienil e furilcarbonil) glutâmico
FI931574A7 (fi) 4-substituerade pyrazolo/3,4-d/pyrimidinderivat

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee