ATE108175T1 - Ester von l-carnitin mit gamma-hydroxybuttersäure und diesen enthaltende pharmazeutische zusammensetzungen zur hemmung neuronaler degeneration und zur behandlung von koma. - Google Patents

Ester von l-carnitin mit gamma-hydroxybuttersäure und diesen enthaltende pharmazeutische zusammensetzungen zur hemmung neuronaler degeneration und zur behandlung von koma.

Info

Publication number: ATE108175T1
Authority: AT; Austria
Prior art keywords: acid; coma; treatment; carnitine; ester
Prior art date: 1989-10-20

Application number

AT90830465T

Other languages

English (en)

Inventor

Maria Ornella Tinti

Domenico Misiti

Claudio Cavazza

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-20

Filing date

1990-10-18

Publication date

1994-07-15

1990-10-18 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE108175T1 publication Critical patent/ATE108175T1/de

Links

SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title abstract 2
206010010071 Coma Diseases 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
230000004770 neurodegeneration Effects 0.000 title abstract 2
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 7
150000003839 salts Chemical class 0.000 abstract 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
-1 L-carnitine ester Chemical class 0.000 abstract 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90830465T 1989-10-20 1990-10-18 Ester von l-carnitin mit gamma-hydroxybuttersäure und diesen enthaltende pharmazeutische zusammensetzungen zur hemmung neuronaler degeneration und zur behandlung von koma. ATE108175T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT04847589A IT1238344B (it)	1989-10-20	1989-10-20	Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma

Publications (1)

Publication Number	Publication Date
ATE108175T1 true ATE108175T1 (de)	1994-07-15

Family

ID=11266785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90830465T ATE108175T1 (de)	1989-10-20	1990-10-18	Ester von l-carnitin mit gamma-hydroxybuttersäure und diesen enthaltende pharmazeutische zusammensetzungen zur hemmung neuronaler degeneration und zur behandlung von koma.

Country Status (8)

Country	Link
US (1)	US5547986A (de)
EP (1)	EP0429403B1 (de)
JP (1)	JP2883187B2 (de)
AT (1)	ATE108175T1 (de)
DE (1)	DE69010459T2 (de)
DK (1)	DK0429403T3 (de)
ES (1)	ES2056432T3 (de)
IT (1)	IT1238344B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1276225B1 (it) *	1995-10-17	1997-10-27	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it)	1995-12-15	1997-10-27	Sigma Tau Ind Farmaceuti	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
DK0951909T4 (da)	1998-03-19	2011-01-24	Sigma Tau Ind Farmaceuti	Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
DE60036863T2 (de)	1999-03-25	2008-07-31	Metabolix, Inc., Cambridge	Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
AU783104B2 (en)	1999-09-14	2005-09-22	Tepha, Inc.	Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
AU2001291173A1 (en) *	2000-09-22	2002-04-02	Orphan Medical, Inc.	Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
EP1638615B1 (de)	2003-05-08	2014-10-29	Tepha, Inc.	Medizinische polyhydroxyalkanoat-textilien und fasern
ES2362217T3 (es)	2004-08-03	2011-06-29	Tepha, Inc.	Suturas de polihidroxialcanoato no rizadas.
US7943683B2 (en)	2006-12-01	2011-05-17	Tepha, Inc.	Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
CA2958747C (en)	2014-08-15	2022-08-16	Tepha, Inc.	Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en)	2014-12-11	2020-04-21	Tepha, Inc.	Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en)	2014-12-11	2017-01-31	Tepha, Inc.	Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
CN108283000B (zh)	2015-09-23	2021-04-13	凯瑞康宁生物工程（武汉）有限公司	γ-羟基丁酸的前药及其组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) *	1980-03-06	1986-11-05	Sigma Tau Ind Farmaceuti	Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) *	1984-06-29	1989-08-30	Magis Farmaceutici	Derivati della l-carnitina o di l-acil carnitina.
IT1231751B (it) *	1989-04-12	1991-12-21	Sigma Tau Ind Farmaceuti	Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina

1989
- 1989-10-20 IT IT04847589A patent/IT1238344B/it active IP Right Grant
1990
- 1990-10-18 ES ES90830465T patent/ES2056432T3/es not_active Expired - Lifetime
- 1990-10-18 DK DK90830465.2T patent/DK0429403T3/da active
- 1990-10-18 DE DE69010459T patent/DE69010459T2/de not_active Expired - Fee Related
- 1990-10-18 AT AT90830465T patent/ATE108175T1/de not_active IP Right Cessation
- 1990-10-18 EP EP90830465A patent/EP0429403B1/de not_active Expired - Lifetime
- 1990-10-19 JP JP2283250A patent/JP2883187B2/ja not_active Expired - Fee Related
1995
- 1995-03-29 US US08/412,858 patent/US5547986A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2056432T3 (es)	1994-10-01
HK1005858A1 (en)	1999-01-29
DK0429403T3 (da)	1994-08-01
JP2883187B2 (ja)	1999-04-19
EP0429403A2 (de)	1991-05-29
DE69010459T2 (de)	1994-10-20
DE69010459D1 (de)	1994-08-11
US5547986A (en)	1996-08-20
JPH03173854A (ja)	1991-07-29
EP0429403A3 (en)	1991-10-02
EP0429403B1 (de)	1994-07-06
IT1238344B (it)	1993-07-13
IT8948475A0 (it)	1989-10-20
IT8948475A1 (it)	1991-04-20

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Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee