DK0429403T3 - Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma - Google Patents

Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma

Info

Publication number: DK0429403T3
Authority: DK; Denmark
Prior art keywords: acid; coma; gamma; treatment; carnitine
Prior art date: 1989-10-20

Application number

DK90830465.2T

Other languages

English (en)

Inventor

Domenico Misiti

Maria Ornella Tinti

Claudio Cavazza

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-20

Filing date

1990-10-18

Publication date

1994-08-01

1990-10-18 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1994-08-01 Application granted granted Critical

1994-08-01 Publication of DK0429403T3 publication Critical patent/DK0429403T3/da

Links

SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title abstract 2
206010010071 Coma Diseases 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
230000004770 neurodegeneration Effects 0.000 title abstract 2
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 7
150000003839 salts Chemical class 0.000 abstract 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
-1 L-carnitine ester Chemical class 0.000 abstract 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90830465.2T 1989-10-20 1990-10-18 Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma DK0429403T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT04847589A IT1238344B (it)	1989-10-20	1989-10-20	Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma

Publications (1)

Publication Number	Publication Date
DK0429403T3 true DK0429403T3 (da)	1994-08-01

Family

ID=11266785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90830465.2T DK0429403T3 (da)	1989-10-20	1990-10-18	Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma

Country Status (8)

Country	Link
US (1)	US5547986A (da)
EP (1)	EP0429403B1 (da)
JP (1)	JP2883187B2 (da)
AT (1)	ATE108175T1 (da)
DE (1)	DE69010459T2 (da)
DK (1)	DK0429403T3 (da)
ES (1)	ES2056432T3 (da)
IT (1)	IT1238344B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1276225B1 (it) *	1995-10-17	1997-10-27	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it)	1995-12-15	1997-10-27	Sigma Tau Ind Farmaceuti	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
DK0951909T4 (da)	1998-03-19	2011-01-24	Sigma Tau Ind Farmaceuti	Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
DE60036863T2 (de)	1999-03-25	2008-07-31	Metabolix, Inc., Cambridge	Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
AU783104B2 (en)	1999-09-14	2005-09-22	Tepha, Inc.	Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
AU2001291173A1 (en) *	2000-09-22	2002-04-02	Orphan Medical, Inc.	Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
EP1638615B1 (en)	2003-05-08	2014-10-29	Tepha, Inc.	Polyhydroxyalkanoate medical textiles and fibers
ES2362217T3 (es)	2004-08-03	2011-06-29	Tepha, Inc.	Suturas de polihidroxialcanoato no rizadas.
US7943683B2 (en)	2006-12-01	2011-05-17	Tepha, Inc.	Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
CA2958747C (en)	2014-08-15	2022-08-16	Tepha, Inc.	Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en)	2014-12-11	2020-04-21	Tepha, Inc.	Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en)	2014-12-11	2017-01-31	Tepha, Inc.	Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
CN108283000B (zh)	2015-09-23	2021-04-13	凯瑞康宁生物工程（武汉）有限公司	γ-羟基丁酸的前药及其组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) *	1980-03-06	1986-11-05	Sigma Tau Ind Farmaceuti	Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) *	1984-06-29	1989-08-30	Magis Farmaceutici	Derivati della l-carnitina o di l-acil carnitina.
IT1231751B (it) *	1989-04-12	1991-12-21	Sigma Tau Ind Farmaceuti	Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina

1989
- 1989-10-20 IT IT04847589A patent/IT1238344B/it active IP Right Grant
1990
- 1990-10-18 ES ES90830465T patent/ES2056432T3/es not_active Expired - Lifetime
- 1990-10-18 DK DK90830465.2T patent/DK0429403T3/da active
- 1990-10-18 DE DE69010459T patent/DE69010459T2/de not_active Expired - Fee Related
- 1990-10-18 AT AT90830465T patent/ATE108175T1/de not_active IP Right Cessation
- 1990-10-18 EP EP90830465A patent/EP0429403B1/en not_active Expired - Lifetime
- 1990-10-19 JP JP2283250A patent/JP2883187B2/ja not_active Expired - Fee Related
1995
- 1995-03-29 US US08/412,858 patent/US5547986A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2056432T3 (es)	1994-10-01
HK1005858A1 (en)	1999-01-29
JP2883187B2 (ja)	1999-04-19
EP0429403A2 (en)	1991-05-29
DE69010459T2 (de)	1994-10-20
DE69010459D1 (de)	1994-08-11
US5547986A (en)	1996-08-20
JPH03173854A (ja)	1991-07-29
EP0429403A3 (en)	1991-10-02
ATE108175T1 (de)	1994-07-15
EP0429403B1 (en)	1994-07-06
IT1238344B (it)	1993-07-13
IT8948475A0 (it)	1989-10-20
IT8948475A1 (it)	1991-04-20

Publication	Publication Date	Title
DK0442850T3 (da)	1994-09-05	Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma
EP0429403A3 (en)	1991-10-02	Ester of l-carnitine with gamma-hydroxybutyric acid and pharmaceutical compositions containing it for inhibiting neuronal degeneration and for the treatment of coma
ES2040242T3 (es)	1993-10-16	Composiciones farmaceuticas.
IT1229203B (it)	1991-07-25	Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
DK0443996T3 (da)	1994-07-25	Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma
WO2003041646A3 (en)	2003-07-24	L-dopa ethyl ester salts and uses thereof
DE69629273D1 (de)	2003-09-04	Zusammensetzungen enthaltend Propionyl-L-Carnitine und Hydroxyzitronensäure oder Pantothensäure
NZ234672A (en)	1991-11-26	N-(1,2,3,4-tetrahydro-9-acridinyl)amide and carbamate derivatives and pharmaceutical compositions
ATE127780T1 (de)	1995-09-15	Alkanoyl l-carnitin-amide mit aminosäuren und diese enthaltende pharmazeutische zusammensetzungen zur förderung von nerven- regenierung, zur inhibierung von neuronaler degeneration zur verbesserung des gedächtnisses und des lernvermögens und zur behandlung von koma.
CA2141679A1 (en)	1994-02-17	New Derivatives of Neuraminic Acid
DE69207479T2 (de)	1996-05-23	Verwendung der Ester von Acyl-L-Carnitin mit Gamma-Hydroxy-Buttersäure zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Lebererkrankungen
HUT61993A (en)	1993-03-29	Process for producing new imidazolylmethylpyridyl derivatives and pharmaceutical compositions comprising same as active ingredient
IL101560A0 (en)	1992-12-30	Condensed diazepinones,their preparation and pharmaceutical compositions containing them
TW207543B (da)	1993-06-11
US6713497B1 (en)	2004-03-30	Use of vitamin B6 to mitigate visual field defects associated with the use of GABAergic drugs in mammals
DE3661919D1 (en)	1989-03-02	L-phosphoserine salts, a process for the preparation thereof and pharmaceutical compositions containing them
GR3033394T3 (en)	2000-09-29	New alkaloid derivatives, their use and pharmaceutical formulations containing them.