ATE108183T1 - 2',3'-dideoxyribofuranoxid-derivate. - Google Patents

2',3'-dideoxyribofuranoxid-derivate.

Info

Publication number: ATE108183T1
Authority: AT; Austria
Prior art keywords: group; acylated; dideoxyribofuranoxide; derivatives; formula
Prior art date: 1987-03-24

Application number

AT88902532T

Other languages

English (en)

Inventor

Jo Klaveness

Frode Rise

Kjell Undheim

Original Assignee

Nycomed Imaging As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-24

Filing date

1988-03-23

Publication date

1994-07-15

1987-03-24 Priority claimed from GB878706991A external-priority patent/GB8706991D0/en

1987-06-09 Priority claimed from GB878713464A external-priority patent/GB8713464D0/en

1988-03-23 Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As

1994-07-15 Application granted granted Critical

1994-07-15 Publication of ATE108183T1 publication Critical patent/ATE108183T1/de

Links

RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 1
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical group O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 1
230000002276 neurotropic effect Effects 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT88902532T 1987-03-24 1988-03-23 2',3'-dideoxyribofuranoxid-derivate. ATE108183T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878706991A GB8706991D0 (en)	1987-03-24	1987-03-24	Chemical compounds
GB878713464A GB8713464D0 (en)	1987-06-09	1987-06-09	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE108183T1 true ATE108183T1 (de)	1994-07-15

Family

ID=26292055

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88902532T ATE108183T1 (de)	1987-03-24	1988-03-23	2',3'-dideoxyribofuranoxid-derivate.

Country Status (9)

Country	Link
EP (1)	EP0342203B1 (de)
JP (1)	JPH02503312A (de)
AT (1)	ATE108183T1 (de)
AU (1)	AU613026B2 (de)
DE (1)	DE3850571T2 (de)
FI (1)	FI93217C (de)
NZ (1)	NZ223990A (de)
OA (1)	OA09242A (de)
WO (1)	WO1988007532A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5223263A (en) *	1988-07-07	1993-06-29	Vical, Inc.	Liponucleotide-containing liposomes
US6448392B1 (en)	1985-03-06	2002-09-10	Chimerix, Inc.	Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
NZ223910A (en) *	1987-03-20	1991-02-26	Bristol Myers Co	2',3'-dideoxynucleosides, process for their production and intermediates therefor
IL86007A0 (en) *	1987-04-09	1988-09-30	Wellcome Found	6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
ZA886890B (en) *	1987-10-09	1989-05-30	Hoffmann La Roche	Novel dideoxycytidine derivatives
US6252060B1 (en)	1988-07-07	2001-06-26	Nexstar Pharmaceuticals, Inc.	Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en)	1988-07-07	2003-07-29	Chimerix, Inc.	Methods of treating viral infections using antiviral liponucleotides
US5817638A (en) *	1988-07-07	1998-10-06	Nexstar Pharmaceuticals, Inc.	Antiviral liponucleosides: treatment of hepatitis B
GB8823320D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds
JPH02164881A (ja) *	1988-10-24	1990-06-25	Wellcome Found Ltd:The	治療用ヌクレオシド化合物
US5059690A (en) *	1990-03-01	1991-10-22	E. R. Squibb & Sons, Inc.	Purinyl tetrahydrofurans
US5145960A (en) *	1989-04-24	1992-09-08	E. R. Squibb & Sons, Inc.	Pyrimidinyl tetrahydrofurans
NZ232993A (en) *	1989-04-24	1992-10-28	Squibb & Sons Inc	Purinyl and pyrimidinyl tetrahydrofurans
US5164520A (en) *	1989-04-24	1992-11-17	E. R. Squibb & Sons, Inc.	Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5071983A (en) *	1989-10-06	1991-12-10	Burroughs Wellcome Co.	Therapeutic nucleosides
EP0500610A1 (de) *	1989-11-06	1992-09-02	Nycomed Imaging As	Nukleosidderivate
US5827727A (en)	1990-02-01	1998-10-27	Emory University	Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
US5914331A (en) *	1990-02-01	1999-06-22	Emory University	Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US6703396B1 (en)	1990-02-01	2004-03-09	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
GB9007569D0 (en) *	1990-04-04	1990-05-30	Nycomed As	Carbo-nucleoside derivatives
WO1991015498A2 (en) *	1990-04-04	1991-10-17	Nycomed Imaging As	Nucleoside derivatives
US5817667A (en) *	1991-04-17	1998-10-06	University Of Georgia Research Foudation	Compounds and methods for the treatment of cancer
ES2067395B1 (es) *	1993-03-10	1996-01-01	Norsk Hydro As	Derivados de nucleosidos o analogos a nucleosidos.
US20020120130A1 (en)	1993-09-10	2002-08-29	Gilles Gosselin	2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
CA2637774C (en)	1993-09-10	2011-07-19	Emory University	Nucleosides with anti-hepatitis b virus activity
US5587362A (en) *	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
IL115156A (en)	1994-09-06	2000-07-16	Univ Georgia	Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en)	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) *	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ATE346651T1 (de)	1995-06-07	2006-12-15	Univ Emory	Nucleoside mit anti-hepatitis b virus wirksamkeit
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
US6436948B1 (en)	2000-03-03	2002-08-20	University Of Georgia Research Foundation Inc.	Method for the treatment of psoriasis and genital warts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4177348A (en) *	1977-12-13	1979-12-04	United States Government	Carbocyclic analogs of cytosine nucleosides
NZ216172A (en) *	1985-05-15	1989-08-29	Wellcome Found	Nucleosides and pharmaceutical compositions
GB8712691D0 (en) *	1987-05-29	1987-07-01	Wellcome Found	Therapeutic nucleosides
GB8823320D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds

1988
- 1988-03-23 DE DE3850571T patent/DE3850571T2/de not_active Expired - Fee Related
- 1988-03-23 WO PCT/GB1988/000224 patent/WO1988007532A1/en not_active Ceased
- 1988-03-23 NZ NZ223990A patent/NZ223990A/xx unknown
- 1988-03-23 EP EP88902532A patent/EP0342203B1/de not_active Expired - Lifetime
- 1988-03-23 JP JP63502580A patent/JPH02503312A/ja active Pending
- 1988-03-23 AT AT88902532T patent/ATE108183T1/de active
- 1988-03-23 AU AU14893/88A patent/AU613026B2/en not_active Ceased
1989
- 1989-09-18 FI FI894397A patent/FI93217C/fi not_active IP Right Cessation
- 1989-09-19 OA OA59645A patent/OA09242A/xx unknown

Also Published As

Publication number	Publication date
FI93217C (fi)	1995-03-10
AU1489388A (en)	1988-11-02
DE3850571T2 (de)	1994-10-27
FI894397L (fi)	1989-09-18
JPH02503312A (ja)	1990-10-11
EP0342203B1 (de)	1994-07-06
AU613026B2 (en)	1991-07-25
EP0342203A1 (de)	1989-11-23
DE3850571D1 (de)	1994-08-11
FI894397A0 (fi)	1989-09-18
WO1988007532A1 (en)	1988-10-06
NZ223990A (en)	1990-08-28
FI93217B (fi)	1994-11-30
OA09242A (en)	1992-06-30

Publication	Publication Date	Title
DE3850571D1 (de)	1994-08-11	2',3'-dideoxyribofuranoxid-derivate.
FR2596761B1 (fr)	1988-05-20	Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
PT1153924E (pt)	2005-01-31	1,3-oxatiolanos substituidos com propriedades anti-virais
IL88755A (en)	1993-01-31	(1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same
DE69031057D1 (de)	1997-08-21	Nucleosidanaloge
BE905109A (fr)	1987-01-15	Derives de distamycine et leur procede de fabrication.
BG95145A (bg)	1993-12-24	Метод за получаване на 9-заместени гуанинови производни
KR940005656A (ko)	1994-03-22	항 바이러스 및 항암 활성을 갖는 2'-데옥시-2', 2'-디플루오로(2,6,8-치환된) 퓨린 뉴클레오시드 및 중간체
AU670154B2 (en)	1996-07-04	Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
HUP9903632A2 (hu)	2001-08-28	Neuraminsav vegyületek, azokat tartalmazó gyógyszerkészítmények és eljárás e készítmények előállítására
ES8501416A1 (es)	1984-11-16	5'-alquil o alquenil-fosfatos de nucleosidos.
NO176052C (no)	1995-01-25	Analogifremgangsmåte for fremstilling av terapeutisk aktive nukleosidderivater
ATE152708T1 (de)	1997-05-15	(1,2n) und (3,2n)-karbozyklische-2-amino- tetralinderivate
ATE122037T1 (de)	1995-05-15	Cyclohexanacetamid-derivate.
DK0654473T3 (da)	2000-03-20	Cyclopropanderivater og antivirale midler med indhold deraf
DK0570850T3 (da)	1997-06-16	Benzo(b)thiophen-3-yl-piperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
AU6101390A (en)	1991-02-21	Substituted purines for use in the treatment of viruses
EP0401049A3 (de)	1991-12-27	Beta-lactam-Elastase-Inhibitoren
ES2067395A1 (es)	1995-03-16	Derivados de nucleosidos o analogos a nucleosidos.