OA09242A - 2', 3' Dideoxyribofuranoxide derivatives. - Google Patents

2', 3' Dideoxyribofuranoxide derivatives.

Info

Publication number: OA09242A
Authority: OA; OAPI
Prior art keywords: group; acylated; dideoxyribofuranoxide; derivatives; formula
Prior art date: 1987-03-24

Application number

OA59645A

Other languages

English (en)

Inventor

Jo Klaveness

Frode Rise

Kjell Undheim

Original Assignee

Nycomed A S Norvege

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-24

Filing date

1989-09-19

Publication date

1992-06-30

1987-03-24 Priority claimed from GB878706991A external-priority patent/GB8706991D0/en

1987-06-09 Priority claimed from GB878713464A external-priority patent/GB8713464D0/en

1989-09-19 Application filed by Nycomed A S Norvege filed Critical Nycomed A S Norvege

1992-06-30 Publication of OA09242A publication Critical patent/OA09242A/xx

Links

RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 1
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical group O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 1
230000002276 neurotropic effect Effects 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

OA59645A 1987-03-24 1989-09-19 2', 3' Dideoxyribofuranoxide derivatives. OA09242A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878706991A GB8706991D0 (en)	1987-03-24	1987-03-24	Chemical compounds
GB878713464A GB8713464D0 (en)	1987-06-09	1987-06-09	Chemical compounds

Publications (1)

Publication Number	Publication Date
OA09242A true OA09242A (en)	1992-06-30

Family

ID=26292055

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA59645A OA09242A (en)	1987-03-24	1989-09-19	2', 3' Dideoxyribofuranoxide derivatives.

Country Status (9)

Country	Link
EP (1)	EP0342203B1 (de)
JP (1)	JPH02503312A (de)
AT (1)	ATE108183T1 (de)
AU (1)	AU613026B2 (de)
DE (1)	DE3850571T2 (de)
FI (1)	FI93217C (de)
NZ (1)	NZ223990A (de)
OA (1)	OA09242A (de)
WO (1)	WO1988007532A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6448392B1 (en)	1985-03-06	2002-09-10	Chimerix, Inc.	Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5223263A (en) *	1988-07-07	1993-06-29	Vical, Inc.	Liponucleotide-containing liposomes
NZ223910A (en) *	1987-03-20	1991-02-26	Bristol Myers Co	2',3'-dideoxynucleosides, process for their production and intermediates therefor
IL86007A0 (en) *	1987-04-09	1988-09-30	Wellcome Found	6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
ZA886890B (en) *	1987-10-09	1989-05-30	Hoffmann La Roche	Novel dideoxycytidine derivatives
US6599887B2 (en)	1988-07-07	2003-07-29	Chimerix, Inc.	Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en)	1988-07-07	2001-06-26	Nexstar Pharmaceuticals, Inc.	Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) *	1988-07-07	1998-10-06	Nexstar Pharmaceuticals, Inc.	Antiviral liponucleosides: treatment of hepatitis B
GB8823320D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds
EP0366385B1 (de) *	1988-10-24	1993-06-09	The Wellcome Foundation Limited	Guaninderivate mit antiviraler Wirkung und deren pharmazeutisch verträgliche Salze
NZ232993A (en) *	1989-04-24	1992-10-28	Squibb & Sons Inc	Purinyl and pyrimidinyl tetrahydrofurans
US5164520A (en) *	1989-04-24	1992-11-17	E. R. Squibb & Sons, Inc.	Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5059690A (en) *	1990-03-01	1991-10-22	E. R. Squibb & Sons, Inc.	Purinyl tetrahydrofurans
US5145960A (en) *	1989-04-24	1992-09-08	E. R. Squibb & Sons, Inc.	Pyrimidinyl tetrahydrofurans
US5071983A (en) *	1989-10-06	1991-12-10	Burroughs Wellcome Co.	Therapeutic nucleosides
JPH05501404A (ja) *	1989-11-06	1993-03-18	ニユコメド・アクシエセルカペト	ヌクレオシド誘導体
US6703396B1 (en)	1990-02-01	2004-03-09	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
US6069252A (en)	1990-02-01	2000-05-30	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
US6642245B1 (en)	1990-02-01	2003-11-04	Emory University	Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
GB9007569D0 (en) *	1990-04-04	1990-05-30	Nycomed As	Carbo-nucleoside derivatives
JPH05505815A (ja) *	1990-04-04	1993-08-26	ニユコメド・イメージング・アクシエセルカペト	ヌクレオシド誘導体
US5817667A (en) *	1991-04-17	1998-10-06	University Of Georgia Research Foudation	Compounds and methods for the treatment of cancer
ES2067395B1 (es) *	1993-03-10	1996-01-01	Norsk Hydro As	Derivados de nucleosidos o analogos a nucleosidos.
US20020120130A1 (en)	1993-09-10	2002-08-29	Gilles Gosselin	2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
AU7954694A (en) *	1993-09-10	1995-03-27	Centre National De La Recherche Scientifique (Cnrs)	Nucleosides with anti-hepatitis b virus activity
US5587362A (en) *	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
IL115156A (en)	1994-09-06	2000-07-16	Univ Georgia	Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en)	1995-01-27	2002-05-21	Emory University	[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) *	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) *	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ES2276404T3 (es)	1995-06-07	2007-06-16	Emory University	Nucleosidos con actividad antivirus de la hepatitis-b.
US5753789A (en) *	1996-07-26	1998-05-19	Yale University	Oligonucleotides containing L-nucleosides
US6436948B1 (en)	2000-03-03	2002-08-20	University Of Georgia Research Foundation Inc.	Method for the treatment of psoriasis and genital warts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4177348A (en) *	1977-12-13	1979-12-04	United States Government	Carbocyclic analogs of cytosine nucleosides
PT82580B (pt) *	1985-05-15	1989-01-17	Wellcome Found	Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
GB8712691D0 (en) *	1987-05-29	1987-07-01	Wellcome Found	Therapeutic nucleosides
GB8823320D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds

1988
- 1988-03-23 AT AT88902532T patent/ATE108183T1/de active
- 1988-03-23 AU AU14893/88A patent/AU613026B2/en not_active Ceased
- 1988-03-23 DE DE3850571T patent/DE3850571T2/de not_active Expired - Fee Related
- 1988-03-23 JP JP63502580A patent/JPH02503312A/ja active Pending
- 1988-03-23 EP EP88902532A patent/EP0342203B1/de not_active Expired - Lifetime
- 1988-03-23 WO PCT/GB1988/000224 patent/WO1988007532A1/en not_active Ceased
- 1988-03-23 NZ NZ223990A patent/NZ223990A/xx unknown
1989
- 1989-09-18 FI FI894397A patent/FI93217C/fi not_active IP Right Cessation
- 1989-09-19 OA OA59645A patent/OA09242A/xx unknown

Also Published As

Publication number	Publication date
EP0342203A1 (de)	1989-11-23
DE3850571T2 (de)	1994-10-27
EP0342203B1 (de)	1994-07-06
WO1988007532A1 (en)	1988-10-06
FI93217B (fi)	1994-11-30
AU613026B2 (en)	1991-07-25
ATE108183T1 (de)	1994-07-15
JPH02503312A (ja)	1990-10-11
NZ223990A (en)	1990-08-28
FI93217C (fi)	1995-03-10
FI894397A0 (fi)	1989-09-18
AU1489388A (en)	1988-11-02
FI894397L (fi)	1989-09-18
DE3850571D1 (de)	1994-08-11

Publication	Publication Date	Title
AU1489388A (en)	1988-11-02	2',3' dideoxyribofuranoxide derivatives
FR2596761B1 (fr)	1988-05-20	Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
IL88755A (en)	1993-01-31	(1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same
PT1153924E (pt)	2005-01-31	1,3-oxatiolanos substituidos com propriedades anti-virais
KR0167089B1 (en)	1999-03-30	Nucleoside analogs
WO1996018634A3 (de)	1996-08-22	Nucleosid-derivate mit photolabilen schutzgruppen
IL115745A0 (en)	1996-01-19	Acylated benzylglycosides and pharmaceutical compositions containing them
AU670154B2 (en)	1996-07-04	Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
HUT65876A (en)	1994-07-28	Process for producing antiretroviral tripeptide derivatives
HUP9903632A2 (hu)	2001-08-28	Neuraminsav vegyületek, azokat tartalmazó gyógyszerkészítmények és eljárás e készítmények előállítására
ES8501416A1 (es)	1984-11-16	5'-alquil o alquenil-fosfatos de nucleosidos.
NO176052C (no)	1995-01-25	Analogifremgangsmåte for fremstilling av terapeutisk aktive nukleosidderivater
HU900127D0 (en)	1990-03-28	Process for preparation of cyclohexane-acetamide-derivatives
GR3022788T3 (en)	1997-06-30	Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments
PT76903A (en)	1983-07-01	Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same
DK0654473T3 (da)	2000-03-20	Cyclopropanderivater og antivirale midler med indhold deraf
AU6101390A (en)	1991-02-21	Substituted purines for use in the treatment of viruses
EP0401049A3 (de)	1991-12-27	Beta-lactam-Elastase-Inhibitoren
ES2067395A1 (es)	1995-03-16	Derivados de nucleosidos o analogos a nucleosidos.