ATE10842T1 - Indanon-oxyalkyl-piperazinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen. - Google Patents

Indanon-oxyalkyl-piperazinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.

Info

Publication number: ATE10842T1
Authority: AT; Austria
Prior art keywords: see diagramm; preparation; indanone; general formula; physiologically tolerated
Prior art date: 1980-07-11

Application number

AT81105028T

Other languages

English (en)

Inventor

Albrecht Dr. Franke

Dieter Dr. Lenke

Josef Dr. Gries

Harald Dr. Weifenbach

Hans Peter Dr. Hofmann

Horst Dr. Kreiskott

Original Assignee

Basf Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-11

Filing date

1981-06-29

Publication date

1985-01-15

1981-06-29 Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft

1985-01-15 Application granted granted Critical

1985-01-15 Publication of ATE10842T1 publication Critical patent/ATE10842T1/de

Links

QNXSIUBBGPHDDE-UHFFFAOYSA-N indan-1-one Chemical compound C1=CC=C2C(=O)CCC2=C1 QNXSIUBBGPHDDE-UHFFFAOYSA-N 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
239000002253 acid Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
150000004885 piperazines Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT81105028T 1980-07-11 1981-06-29 Indanon-oxyalkyl-piperazinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen. ATE10842T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19803026331 DE3026331A1 (de)	1980-07-11	1980-07-11	Indanon-oxyalkyl-piperazinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitung
EP81105028A EP0043971B1 (de)	1980-07-11	1981-06-29	Indanon-oxyalkyl-piperazinderivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number	Publication Date
ATE10842T1 true ATE10842T1 (de)	1985-01-15

Family

ID=6106977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT81105028T ATE10842T1 (de)	1980-07-11	1981-06-29	Indanon-oxyalkyl-piperazinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.

Country Status (9)

Country	Link
EP (1)	EP0043971B1 (de)
JP (1)	JPS5748978A (de)
AT (1)	ATE10842T1 (de)
CA (1)	CA1193601A (de)
DE (2)	DE3026331A1 (de)
DK (1)	DK308881A (de)
GR (1)	GR74879B (de)
IE (1)	IE51383B1 (de)
ZA (1)	ZA814688B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE396178T1 (de) *	2004-10-08	2008-06-15	Suven Life Sciences Ltd	Verfahren zur herstellung von aripiprazol, und entsprechende zwischenprodukte und deren herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7101573A (de) *	1970-04-13	1971-10-15
DE2335432A1 (de) *	1973-07-12	1975-01-30	Boehringer Mannheim Gmbh	3,4-dihydro-2h-naphthalinon-(1)5-oxy-propyl-piperazin-derivate und verfahren zu ihrer herstellung
US4130646A (en) *	1975-07-25	1978-12-19	E. R. Squibb & Sons, Inc.	1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
DE2824677A1 (de) *	1978-06-06	1979-12-20	Hoechst Ag	Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung

1980
- 1980-07-11 DE DE19803026331 patent/DE3026331A1/de not_active Withdrawn
1981
- 1981-06-24 GR GR65333A patent/GR74879B/el unknown
- 1981-06-29 DE DE8181105028T patent/DE3167816D1/de not_active Expired
- 1981-06-29 EP EP81105028A patent/EP0043971B1/de not_active Expired
- 1981-06-29 AT AT81105028T patent/ATE10842T1/de not_active IP Right Cessation
- 1981-07-09 JP JP56106305A patent/JPS5748978A/ja active Pending
- 1981-07-09 CA CA000381476A patent/CA1193601A/en not_active Expired
- 1981-07-10 IE IE1560/81A patent/IE51383B1/en unknown
- 1981-07-10 DK DK308881A patent/DK308881A/da not_active Application Discontinuation
- 1981-07-10 ZA ZA814688A patent/ZA814688B/xx unknown

Also Published As

Publication number	Publication date
GR74879B (de)	1984-07-12
IE51383B1 (en)	1986-12-10
EP0043971B1 (de)	1984-12-19
ZA814688B (en)	1982-08-25
DE3167816D1 (en)	1985-01-31
CA1193601A (en)	1985-09-17
JPS5748978A (en)	1982-03-20
IE811560L (en)	1982-01-11
DE3026331A1 (de)	1982-02-18
EP0043971A1 (de)	1982-01-20
DK308881A (da)	1982-01-12

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Legal Events

Date	Code	Title	Description
1988-03-15	REN	Ceased due to non-payment of the annual fee