ATE108825T1 - Verfahren zur herstellung von menschlichem gewebeplasminogenaktivator. - Google Patents

Verfahren zur herstellung von menschlichem gewebeplasminogenaktivator.

Info

Publication number
ATE108825T1
ATE108825T1 AT89304944T AT89304944T ATE108825T1 AT E108825 T1 ATE108825 T1 AT E108825T1 AT 89304944 T AT89304944 T AT 89304944T AT 89304944 T AT89304944 T AT 89304944T AT E108825 T1 ATE108825 T1 AT E108825T1
Authority
AT
Austria
Prior art keywords
tpa
production
plasminogen activator
medium
human tissue
Prior art date
Application number
AT89304944T
Other languages
English (en)
Inventor
Soichiro Miyahara
Atsunori Shindo
Nobuyoshi Makiguchi
Maki Suzuki
Nobumi Kusuhara
Iijimacho
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12264488A external-priority patent/JP2648611B2/ja
Priority claimed from JP63316118A external-priority patent/JP2718726B2/ja
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Application granted granted Critical
Publication of ATE108825T1 publication Critical patent/ATE108825T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT89304944T 1988-05-19 1989-05-16 Verfahren zur herstellung von menschlichem gewebeplasminogenaktivator. ATE108825T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12264488A JP2648611B2 (ja) 1988-05-19 1988-05-19 ヒト組織型プラスミノーゲン活性化因子の製法
JP63316118A JP2718726B2 (ja) 1988-12-16 1988-12-16 ヒト組織型プラスミノーゲン活性化因子の製法

Publications (1)

Publication Number Publication Date
ATE108825T1 true ATE108825T1 (de) 1994-08-15

Family

ID=26459739

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89304944T ATE108825T1 (de) 1988-05-19 1989-05-16 Verfahren zur herstellung von menschlichem gewebeplasminogenaktivator.

Country Status (10)

Country Link
US (1) US5151359A (de)
EP (1) EP0342931B1 (de)
AT (1) ATE108825T1 (de)
AU (1) AU612837B2 (de)
CA (1) CA1334288C (de)
DE (1) DE68916857T2 (de)
DK (1) DK243589A (de)
FI (1) FI98123C (de)
NO (1) NO175541C (de)
NZ (1) NZ229187A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183754A (en) * 1988-10-04 1993-02-02 Mitsui Toatsu Chemicals, Incorporated Method for production of human tissue type plasminogen activator
US5824552A (en) * 1994-02-18 1998-10-20 Teijin Limited Medium for culturing animal cells
US5856179A (en) * 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
AU2002316230A1 (en) * 2001-06-13 2002-12-23 Genentech, Inc. Methods of culturing animal cells and polypeptide production in animal cells
CA2829774C (en) 2011-03-14 2019-09-24 National Research Council Of Canada Method of viral production in cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732146A (en) * 1970-12-22 1973-05-08 Behringwerke Ag Process for the isolation of native, highly purified plasminogen
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
FR2548211B1 (fr) * 1983-06-29 1985-10-18 Choay Sa Procede de production d'un activateur tissulaire du plasminogene et activateur obtenu par ce procede
US4554251A (en) * 1983-11-07 1985-11-19 The Ohio State University Research Foundation Process and medium for culturing ant venom gland cells
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
US4724206A (en) * 1984-02-13 1988-02-09 Damon Biotech, Inc. Protein production using hypertonic media
EP0163751B1 (de) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Verfahren zur Herstellung eines Plasminogenaktivators
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
US4661469A (en) * 1984-08-08 1987-04-28 Survival Technology, Inc. t-PA composition capable of being absorbed into the blood stream and method of administration
JPS624233A (ja) * 1985-07-01 1987-01-10 Toyobo Co Ltd 組織性プラスミノ−ゲン活性化因子の製造法
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
US5183754A (en) * 1988-10-04 1993-02-02 Mitsui Toatsu Chemicals, Incorporated Method for production of human tissue type plasminogen activator

Also Published As

Publication number Publication date
DK243589A (da) 1989-11-20
FI892358L (fi) 1989-11-20
FI892358A0 (fi) 1989-05-17
NO175541B (no) 1994-07-18
AU3489289A (en) 1989-11-23
NZ229187A (en) 1991-12-23
FI98123C (fi) 1997-04-25
EP0342931B1 (de) 1994-07-20
NO891995L (no) 1989-11-20
CA1334288C (en) 1995-02-07
NO175541C (no) 1994-10-26
AU612837B2 (en) 1991-07-18
FI98123B (fi) 1997-01-15
EP0342931A1 (de) 1989-11-23
DE68916857T2 (de) 1994-11-10
US5151359A (en) 1992-09-29
DE68916857D1 (de) 1994-08-25
NO891995D0 (no) 1989-05-18
DK243589D0 (da) 1989-05-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee