ATE109794T1 - Von faktor vii abgeleitete peptide mit antihämostatischer wirkung. - Google Patents

Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.

Info

Publication number
ATE109794T1
ATE109794T1 AT91901068T AT91901068T ATE109794T1 AT E109794 T1 ATE109794 T1 AT E109794T1 AT 91901068 T AT91901068 T AT 91901068T AT 91901068 T AT91901068 T AT 91901068T AT E109794 T1 ATE109794 T1 AT E109794T1
Authority
AT
Austria
Prior art keywords
factor vii
derived peptides
hemostatic activity
peptides
vii derived
Prior art date
Application number
AT91901068T
Other languages
English (en)
Inventor
Daryl S Fair
Anuradha Kumar
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE109794T1 publication Critical patent/ATE109794T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT91901068T 1989-11-13 1990-11-13 Von faktor vii abgeleitete peptide mit antihämostatischer wirkung. ATE109794T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/435,657 US5190919A (en) 1989-11-13 1989-11-13 Antihemostatic factor vii peptides

Publications (1)

Publication Number Publication Date
ATE109794T1 true ATE109794T1 (de) 1994-08-15

Family

ID=23729271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901068T ATE109794T1 (de) 1989-11-13 1990-11-13 Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.

Country Status (7)

Country Link
US (1) US5190919A (de)
EP (1) EP0500800B1 (de)
AT (1) ATE109794T1 (de)
AU (1) AU6963491A (de)
DE (1) DE69011531T2 (de)
DK (1) DK0500800T3 (de)
WO (1) WO1991007432A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5861374A (en) * 1991-02-28 1999-01-19 Novo Nordisk A/S Modified Factor VII
US5833982A (en) * 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
US5817788A (en) * 1991-02-28 1998-10-06 Zymogenetics, Inc. Modified factor VII
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
US5788965A (en) * 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
JPH06505496A (ja) * 1991-03-11 1994-06-23 ザ・ジェネラル・ホスピタル・コーポレーション 活性因子ｘ１１１の活性化を阻害するための組成物と方法
JP3180824B2 (ja) * 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
US6039944A (en) * 1992-02-28 2000-03-21 Zymogenetics, Inc. Modified Factor VII
AU681074B2 (en) * 1992-03-20 1997-08-21 Millennium Pharmaceuticals, Inc. Glycosylation-mediated inhibition of factor X
GB9425381D0 (en) * 1994-12-15 1995-02-15 Nycomed Pharma As Peptides
EP0987274A1 (de) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Faktor VIIa Inhibitore
AU5062100A (en) 1999-06-14 2001-01-02 Novo Nordisk A/S Fviia/tf activity inhibiting compounds
DK3402537T3 (da) 2016-01-15 2021-03-29 Rigshospitalet Kvantitativ PET-afbildning af vævsfaktorekspression under anvendelse af 18-F mærket, aktiv positions-inhiberet faktor VII
WO2018091058A1 (en) 2016-11-17 2018-05-24 Rigshospitalet 177-lu labeled active site inhibited factor vii

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
KR930007434B1 (ko) * 1984-09-21 1993-08-10 베링거 잉겔하임 인터내셔날 게엠베하 혈액응고 억제 단백질 제조방법
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
WO1990003390A1 (en) * 1988-09-23 1990-04-05 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation

Also Published As

Publication number Publication date
WO1991007432A1 (en) 1991-05-30
US5190919A (en) 1993-03-02
DK0500800T3 (da) 1994-12-05
EP0500800A1 (de) 1992-09-02
AU6963491A (en) 1991-06-13
DE69011531T2 (de) 1994-12-08
EP0500800B1 (de) 1994-08-10
DE69011531D1 (de) 1994-09-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee