ATE109970T1 - Cyclosporin-augenmittel. - Google Patents

Cyclosporin-augenmittel.

Info

Publication number: ATE109970T1
Authority: AT; Austria
Prior art keywords: cyclosporine; enhance; corn oil; agents; composition
Prior art date: 1987-09-03

Application number

AT88908033T

Other languages

English (en)

Inventor

Renee Kaswan

Original Assignee

Univ Georgia Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-03

Filing date

1988-08-31

Publication date

1994-09-15

1987-09-03 Priority claimed from US07/092,466 external-priority patent/US4839342A/en

1988-08-31 Application filed by Univ Georgia Res Found filed Critical Univ Georgia Res Found

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE109970T1 publication Critical patent/ATE109970T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229960001265 ciclosporin Drugs 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
229930105110 Cyclosporin A Natural products 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
239000002285 corn oil Substances 0.000 abstract 2
235000005687 corn oil Nutrition 0.000 abstract 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
-1 antifungals Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229940121357 antivirals Drugs 0.000 abstract 1
OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 abstract 1
229960003870 bromhexine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003246 corticosteroid Substances 0.000 abstract 1
229960001334 corticosteroids Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003172 expectorant agent Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
229960002216 methylparaben Drugs 0.000 abstract 1
229940066491 mucolytics Drugs 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
230000004489 tear production Effects 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
239000005526 vasoconstrictor agent Substances 0.000 abstract 1
239000000080 wetting agent Substances 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT88908033T 1987-09-03 1988-08-31 Cyclosporin-augenmittel. ATE109970T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/092,466 US4839342A (en)	1987-09-03	1987-09-03	Method of increasing tear production by topical administration of cyclosporin
US11721887A	1987-11-04	1987-11-04
US18782388A	1988-04-29	1988-04-29

Publications (1)

Publication Number	Publication Date
ATE109970T1 true ATE109970T1 (de)	1994-09-15

Family

ID=27377210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88908033T ATE109970T1 (de)	1987-09-03	1988-08-31	Cyclosporin-augenmittel.

Country Status (12)

Country	Link
US (1)	US5411952A (de)
EP (1)	EP0391909B1 (de)
JP (1)	JPH0667850B2 (de)
KR (1)	KR920003601B1 (de)
AT (1)	ATE109970T1 (de)
DE (1)	DE3851152T2 (de)
DK (1)	DK54390A (de)
ES (1)	ES2012116A6 (de)
GR (1)	GR1000558B (de)
IE (1)	IE65582B1 (de)
PH (1)	PH24814A (de)
WO (1)	WO1989001772A1 (de)

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1988
- 1988-08-31 KR KR1019890700680A patent/KR920003601B1/ko not_active Expired
- 1988-08-31 DE DE3851152T patent/DE3851152T2/de not_active Expired - Lifetime
- 1988-08-31 EP EP88908033A patent/EP0391909B1/de not_active Expired - Lifetime
- 1988-08-31 JP JP63507463A patent/JPH0667850B2/ja not_active Expired - Lifetime
- 1988-08-31 AT AT88908033T patent/ATE109970T1/de not_active IP Right Cessation
- 1988-08-31 WO PCT/US1988/003039 patent/WO1989001772A1/en not_active Ceased
- 1988-09-02 IE IE266388A patent/IE65582B1/en not_active IP Right Cessation
- 1988-09-02 PH PH37495A patent/PH24814A/en unknown
- 1988-09-02 ES ES8802718A patent/ES2012116A6/es not_active Expired - Lifetime
- 1988-09-05 GR GR880100578A patent/GR1000558B/el not_active IP Right Cessation
1990
- 1990-02-06 US US07/474,683 patent/US5411952A/en not_active Expired - Lifetime
- 1990-03-01 DK DK054390A patent/DK54390A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH0667850B2 (ja)	1994-08-31
DE3851152T2 (de)	1995-01-26
EP0391909B1 (de)	1994-08-17
US5411952A (en)	1995-05-02
DE3851152D1 (de)	1994-09-22
IE882663L (en)	1989-03-03
KR890701084A (ko)	1989-12-19
WO1989001772A1 (en)	1989-03-09
GR880100578A (en)	1989-06-22
PH24814A (en)	1990-10-30
DK54390A (da)	1990-05-03
ES2012116A6 (es)	1990-03-01
GR1000558B (el)	1992-08-26
JPH03503159A (ja)	1991-07-18
EP0391909A1 (de)	1990-10-17
DK54390D0 (da)	1990-03-01
KR920003601B1 (ko)	1992-05-04
IE65582B1 (en)	1995-11-01

Legal Events

Date	Code	Title	Description
1995-03-15	UEP	Publication of translation of european patent specification
2008-11-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE109970T1 (de)	1994-09-15	Cyclosporin-augenmittel.
CA1303503C (en)	1992-06-16	Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
ATE205723T1 (de)	2001-10-15	Applikation von sod in liposomen
MX9702349A (es)	1997-06-28	Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma.
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
ATE165237T1 (de)	1998-05-15	Starkschaumende orale zusammensetzung
KR960701049A (ko)	1996-02-24	헤테로사이클릭 화합물, 이의 제조방법 및 이의 용도(Heterocyclic compounds and their preparation and use)
GB2075341B (en)	1983-12-14	Pharmaceutical compositions
IE811654L (en)	1982-02-01	Ophthalmic composition
ATE223200T1 (de)	2002-09-15	Einen carboanhydrase-hemmer und xanthangummi enthaltendes augenarzneimittel
DE69928806D1 (de)	2006-01-12	(-)-pseudoephedrin als sympathomimetisches arzneimittel
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KR880007068A (ko)	1988-08-26	13-시스 레티노산의 용도
KR950702422A (ko)	1995-07-29	(에스)-티몰롤 헤미하이드레이트를 함유하는 안약 국소 조성물(ophthalmic topical composition containing (s)-timolol hemihydrate)
KR880009656A (ko)	1988-10-04	국소 치근막 질환의 치료 또는 예방법
RU95106983A (ru)	1997-11-27	Офтальмологический состав, способ его получения и средство для офтальмологического состава
RISER	1944	Modern trends in ocular therapeutics
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
IT1241928B (it)	1994-02-01	Composizione oftalmica per l'uso nel mantenimento della midriasi oculare
IT1257884B (it)	1996-02-16	Formulazioni farmaceutiche per il trattamento di malattie periferiche vascolari a base di vincamina o di un suo sale farmaceuticamente accettabile.
MY110416A (en)	1998-05-30	Composition for the treatment of schizophrenia.