ATE110080T1 - Verfahren zur herstellung von 7-alpha- alkoxycephemderivaten. - Google Patents
Verfahren zur herstellung von 7-alpha- alkoxycephemderivaten.Info
- Publication number
- ATE110080T1 ATE110080T1 AT91909919T AT91909919T ATE110080T1 AT E110080 T1 ATE110080 T1 AT E110080T1 AT 91909919 T AT91909919 T AT 91909919T AT 91909919 T AT91909919 T AT 91909919T AT E110080 T1 ATE110080 T1 AT E110080T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- alkoxycephem
- alpha
- derivatives
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003602 elastase inhibitor Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909011463A GB9011463D0 (en) | 1990-05-22 | 1990-05-22 | Process for the preparation of 7 alpha-alkoxycephem derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110080T1 true ATE110080T1 (de) | 1994-09-15 |
Family
ID=10676383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91909919T ATE110080T1 (de) | 1990-05-22 | 1991-05-21 | Verfahren zur herstellung von 7-alpha- alkoxycephemderivaten. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5254680A (de) |
| EP (1) | EP0530268B1 (de) |
| JP (1) | JP2957699B2 (de) |
| AT (1) | ATE110080T1 (de) |
| AU (1) | AU652757B2 (de) |
| CA (1) | CA2083143C (de) |
| DE (1) | DE69103528T2 (de) |
| DK (1) | DK0530268T3 (de) |
| ES (1) | ES2062793T3 (de) |
| GB (1) | GB9011463D0 (de) |
| WO (1) | WO1991017997A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604222A (en) | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
| IN184516B (de) * | 1996-01-19 | 2000-09-02 | Lupin Laoratories Ltd | |
| JP2017505612A (ja) | 2014-01-17 | 2017-02-23 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | メタロ−β−ラクタマーゼを発現する細菌を検出するための６，７−トランスセファロスポリンに基づくプローブ |
| CN113788845A (zh) * | 2021-05-17 | 2021-12-14 | 华东理工大学 | 基于头孢菌素母核的7位立体异构体衍生物在抑制金属β-内酰胺酶和耐药细菌中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456755A (en) * | 1974-08-05 | 1984-06-26 | Massachusetts Institute Of Technology | 7-Oxygen analogs of cephalosporins |
| US4093625A (en) * | 1976-08-09 | 1978-06-06 | Massachusetts Institute Of Technology | 6-Sulfur analogs of penicillins and cephalosporins |
| US4637999A (en) | 1983-05-02 | 1987-01-20 | Merck & Co., Inc. | Substituted cephalosporins as anti-inflammatory and antidegenerative agents |
| GB8808701D0 (en) * | 1988-04-13 | 1988-05-18 | Erba Carlo Spa | Beta-lactam derivatives |
| US4992541A (en) * | 1989-08-01 | 1991-02-12 | Merck & Co., Inc. | Process for the preparation of 1,1-dioxo-7-substituted cephems |
-
1990
- 1990-05-22 GB GB909011463A patent/GB9011463D0/en active Pending
-
1991
- 1991-04-25 US US07/691,089 patent/US5254680A/en not_active Expired - Lifetime
- 1991-05-21 WO PCT/EP1991/000945 patent/WO1991017997A1/en not_active Ceased
- 1991-05-21 AU AU78814/91A patent/AU652757B2/en not_active Ceased
- 1991-05-21 DK DK91909919.2T patent/DK0530268T3/da active
- 1991-05-21 DE DE69103528T patent/DE69103528T2/de not_active Expired - Fee Related
- 1991-05-21 CA CA002083143A patent/CA2083143C/en not_active Expired - Fee Related
- 1991-05-21 EP EP91909919A patent/EP0530268B1/de not_active Expired - Lifetime
- 1991-05-21 ES ES91909919T patent/ES2062793T3/es not_active Expired - Lifetime
- 1991-05-21 JP JP3509721A patent/JP2957699B2/ja not_active Expired - Fee Related
- 1991-05-21 AT AT91909919T patent/ATE110080T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2083143A1 (en) | 1991-11-23 |
| DE69103528D1 (de) | 1994-09-22 |
| DK0530268T3 (da) | 1994-09-26 |
| EP0530268A1 (de) | 1993-03-10 |
| DE69103528T2 (de) | 1994-12-22 |
| AU652757B2 (en) | 1994-09-08 |
| WO1991017997A1 (en) | 1991-11-28 |
| GB9011463D0 (en) | 1990-07-11 |
| US5254680A (en) | 1993-10-19 |
| JPH05506865A (ja) | 1993-10-07 |
| CA2083143C (en) | 2001-12-18 |
| JP2957699B2 (ja) | 1999-10-06 |
| ES2062793T3 (es) | 1994-12-16 |
| EP0530268B1 (de) | 1994-08-17 |
| AU7881491A (en) | 1991-12-10 |
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