ATE110268T1 - Verfahren und mittel zur behandlung der alzheimer-krankheit, verwandter demenzen und epilepsie. - Google Patents

Verfahren und mittel zur behandlung der alzheimer-krankheit, verwandter demenzen und epilepsie.

Info

Publication number: ATE110268T1
Authority: AT; Austria
Prior art keywords: derivatives; epilepsy; alzheimer; disease; agent
Prior art date: 1988-10-27

Application number

AT89311089T

Other languages

English (en)

Inventor

Shlomo Yehuda

Original Assignee

Univ Bar Ilan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-27

Filing date

1989-10-27

Publication date

1994-09-15

1989-07-06 Priority claimed from US07/376,289 external-priority patent/US5120763A/en

1989-09-27 Priority claimed from IL9180289A external-priority patent/IL91802A/en

1989-10-27 Application filed by Univ Bar Ilan filed Critical Univ Bar Ilan

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE110268T1 publication Critical patent/ATE110268T1/de

Links

206010015037 epilepsy Diseases 0.000 title abstract 3
208000024827 Alzheimer disease Diseases 0.000 title abstract 2
206010012289 Dementia Diseases 0.000 title abstract 2
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
235000020778 linoleic acid Nutrition 0.000 abstract 2
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 abstract 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 abstract 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 abstract 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 abstract 1
239000005642 Oleic acid Substances 0.000 abstract 1
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 abstract 1
235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 abstract 1
229960004488 linolenic acid Drugs 0.000 abstract 1
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 abstract 1
235000016709 nutrition Nutrition 0.000 abstract 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000004671 saturated fatty acids Chemical class 0.000 abstract 1
235000003441 saturated fatty acids Nutrition 0.000 abstract 1
DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical class CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pain & Pain Management (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT89311089T 1988-10-27 1989-10-27 Verfahren und mittel zur behandlung der alzheimer-krankheit, verwandter demenzen und epilepsie. ATE110268T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US26354088A	1988-10-27	1988-10-27
US35956289A	1989-06-01	1989-06-01
US07/376,289 US5120763A (en)	1986-11-26	1989-07-06	Physiologically active and nutritional composition
IL9180289A IL91802A (en)	1988-10-27	1989-09-27	Preparations containing linoleic acid history for the treatment of Alzheimer's, similar brain diseases, and epilepsy

Publications (1)

Publication Number	Publication Date
ATE110268T1 true ATE110268T1 (de)	1994-09-15

Family

ID=27452355

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89311089T ATE110268T1 (de)	1988-10-27	1989-10-27	Verfahren und mittel zur behandlung der alzheimer-krankheit, verwandter demenzen und epilepsie.

Country Status (6)

Country	Link
EP (1)	EP0366480B1 (de)
JP (1)	JP2810725B2 (de)
AT (1)	ATE110268T1 (de)
AU (1)	AU620929B2 (de)
DE (1)	DE68917678T2 (de)
HK (1)	HK1007110A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59107305D1 (de) *	1990-05-22	1996-03-07	Harold Bumann	Verfahren zur herstellung eines fruchtsaft-getränkes
US6103755A (en) *	1990-05-22	2000-08-15	Bumann; Harold	Foodstuff with prophylactic and/or healing effect and process for its production
DE4116004C2 (de) *	1991-05-16	1993-09-30	Fresenius Ag	Nährstoffzubereitung
GB9423625D0 (en) *	1994-11-23	1995-01-11	Scotia Holdings Plc	Fortified fruit juice
DE19549262C2 (de) *	1995-02-08	1997-10-09	Martin Dr Kohlmeier	Präparat zur Abschätzung des Entstehungsrisikos eines beschleunigten Verlustes kognitiver Fähigkeiten
ATE185949T1 (de) *	1995-07-28	1999-11-15	Herbert Schlachter	Zwei-phasen-präparat
CA2298795A1 (en) *	1997-07-28	1999-02-04	The Institute Of Physical And Chemical Research	Agent for protecting central nerve cells and enhancing survival thereof
DE102005037298A1 (de) *	2005-08-08	2007-03-08	Christine Jaschek	Verwendung von Kalium-, Magnesium-, Calcium- und Zink-Elektrolyten zur Behandlung des Elementemangel- und Austrocknungssyndroms Alzheimer und anderer Demenzen
EP1772146A1 (de) *	2005-10-03	2007-04-11	Neuropharma, S.A.	Merfach ungesättigte Fettsäuren als BACE-Inhibitoren
US10052299B2 (en)	2009-10-30	2018-08-21	Retrotope, Inc.	Alleviating oxidative stress disorders with PUFA derivatives
WO2012148930A2 (en)	2011-04-26	2012-11-01	Retrotope, Inc.	Oxidative retinal diseases
KR102112087B1 (ko)	2011-04-26	2020-05-18	레트로토프 인코포레이티드	에너지 프로세싱 손상 장애 및 미토콘드리아 결함
JP6106157B2 (ja)	2011-04-26	2017-03-29	レトロトップ、インコーポレイテッドＲｅｔｒｏｔｏｐｅ，Ｉｎｃ．	神経変性障害および筋疾患に関与するｐｕｆａ
JP6145087B2 (ja)	2011-04-26	2017-06-07	レトロトップ、インコーポレイテッドＲｅｔｒｏｔｏｐｅ，Ｉｎｃ．	Ｐｕｆａ酸化関与障害
KR101493139B1 (ko) *	2013-01-08	2015-02-13	경상대학교산학협력단	타이모퀴논 및 비타민 c를 유효성분으로 포함하는 신경세포 보호용 조성물
JP2016023163A (ja) *	2014-07-22	2016-02-08	出光興産株式会社	γ−リノレン酸を含む神経細胞の酸化ストレス軽減剤
EP3950649A1 (de)	2015-11-23	2022-02-09	Retrotope, Inc.	Ortsspezifische isotopische markierung von 1,4-dien-systemen
IL295783B2 (en)	2020-02-21	2026-03-01	Retrotope Inc	Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives
US12109194B2 (en)	2021-02-05	2024-10-08	Biojiva Llc	Synergistic combination therapy for treating ALS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8524275D0 (en) *	1985-10-02	1985-11-06	Efamol Ltd	Pharmaceutical & dietary compositions
GB8601915D0 (en) *	1986-01-27	1986-03-05	Efamol Ltd	Pharmaceutical compositions
US4851431A (en) *	1986-11-26	1989-07-25	Bar Ilan University	Physiologically active and nutritional composition

1989
- 1989-10-26 AU AU43805/89A patent/AU620929B2/en not_active Ceased
- 1989-10-27 EP EP89311089A patent/EP0366480B1/de not_active Expired - Lifetime
- 1989-10-27 DE DE68917678T patent/DE68917678T2/de not_active Expired - Fee Related
- 1989-10-27 JP JP1278812A patent/JP2810725B2/ja not_active Expired - Fee Related
- 1989-10-27 AT AT89311089T patent/ATE110268T1/de not_active IP Right Cessation
1998
- 1998-06-24 HK HK98106406A patent/HK1007110A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU4380589A (en)	1990-05-03
EP0366480A3 (de)	1991-02-06
DE68917678T2 (de)	1994-12-22
JP2810725B2 (ja)	1998-10-15
EP0366480B1 (de)	1994-08-24
DE68917678D1 (de)	1994-09-29
AU620929B2 (en)	1992-02-27
JPH02237919A (ja)	1990-09-20
EP0366480A2 (de)	1990-05-02
HK1007110A1 (en)	1999-04-01

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Legal Events

Date	Code	Title	Description
1995-03-15	UEP	Publication of translation of european patent specification
2008-07-15	REN	Ceased due to non-payment of the annual fee