ATE110276T1 - Blutersatz. - Google Patents

Blutersatz.

Info

Publication number
ATE110276T1
ATE110276T1 AT88904862T AT88904862T ATE110276T1 AT E110276 T1 ATE110276 T1 AT E110276T1 AT 88904862 T AT88904862 T AT 88904862T AT 88904862 T AT88904862 T AT 88904862T AT E110276 T1 ATE110276 T1 AT E110276T1
Authority
AT
Austria
Prior art keywords
mutant
hemoglobins
solutions
blood substitute
blood substitutes
Prior art date
Application number
AT88904862T
Other languages
English (en)
Inventor
Stephen J Hoffman
Kiyoshi Nagai
Original Assignee
Somatogenetics Int
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10617467&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE110276(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Somatogenetics Int, Medical Res Council filed Critical Somatogenetics Int
Application granted granted Critical
Publication of ATE110276T1 publication Critical patent/ATE110276T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88904862T 1987-05-16 1988-05-13 Blutersatz. ATE110276T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878711614A GB8711614D0 (en) 1987-05-16 1987-05-16 Proteins

Publications (1)

Publication Number Publication Date
ATE110276T1 true ATE110276T1 (de) 1994-09-15

Family

ID=10617467

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88904862T ATE110276T1 (de) 1987-05-16 1988-05-13 Blutersatz.

Country Status (11)

Country Link
US (1) US5028588A (de)
EP (1) EP0358708B1 (de)
JP (1) JP3034529B2 (de)
AT (1) ATE110276T1 (de)
AU (1) AU614525B2 (de)
CA (1) CA1341286C (de)
DE (1) DE3851225T2 (de)
GB (2) GB8711614D0 (de)
HU (1) HU211989A9 (de)
SG (1) SG26593G (de)
WO (1) WO1988009179A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
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US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US6150506A (en) * 1989-05-10 2000-11-21 Baxter Biotech Technology Sarl Modified hemoglobin-like compounds and methods of purifying same
US5599907A (en) * 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
CA2050601C (en) * 1989-05-10 2000-09-19 Stephen J. Hoffman Production in bacteria and yeast of hemoglobin and analogues thereof
US6828125B1 (en) * 1989-05-10 2004-12-07 Baxter Biotech Technology, S.A.R.L. DNA encoding fused di-alpha globins and use thereof
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
CA2025180A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting pathogenic candida yeasts
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
JPH07504645A (ja) * 1990-04-16 1995-05-25 アペックス　バイオサイエンス　インコーポレーテッド 酵母での組換えヘモグロビンの発現
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5622848A (en) * 1990-05-23 1997-04-22 Medical Discoveries, Inc. Electrically hydrolyzed salines as microbiocides for in vitro treatment of contaminated fluids containing blood
US5334383A (en) * 1990-05-23 1994-08-02 Medical Discoveries, Inc. Electrically hydrolyzed salines as in vivo microbicides for treatment of cardiomyopathy and multiple sclerosis
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
JPH06504056A (ja) * 1990-12-20 1994-05-12 ザ・ユニバーシティ・オブ・アラバマ・リサーチ・ファウンデーション トランスジェニック架橋ヘモグロビン
US5610137A (en) * 1990-12-20 1997-03-11 The Uab Research Foundation Transgenic, cross-linked hemoglobin
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
CA2111348A1 (en) * 1991-06-14 1992-12-23 John S. Logan Production of human hemoglobin in transgenic pigs
WO1993008831A1 (en) * 1991-10-30 1993-05-13 Strohtech, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
DE69226197T2 (de) 1991-11-08 1999-02-11 Somatogen, Inc., Boulder Hämoglobine als arzneimittelabgabesystem
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
FR2688784B1 (fr) * 1992-03-18 1995-06-30 Pasteur Merieux Serums Vacc Transporteur d'oxygene.
FI945829A7 (fi) * 1992-06-12 1995-02-10 Dnx Corp Ihmisen hemoglobiinin valmistaminen transgeenisissa sioissa
ATE225370T1 (de) 1993-03-31 2002-10-15 Pro Neuron Inc Inhibitor der stammzellproliferation und seine verwendung
US6610654B2 (en) * 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US5507932A (en) * 1994-08-26 1996-04-16 Schlumberger Technology Corporation Apparatus for electrolyzing fluids
US6117285A (en) * 1994-08-26 2000-09-12 Medical Discoveries, Inc. System for carrying out sterilization of equipment
EP0802805A1 (de) * 1995-01-13 1997-10-29 Somatogen, Inc. Verfahren zum erleichtern von autologen blutspenden und zur behandlung von sauerstoffmangel
US5962651A (en) * 1995-01-27 1999-10-05 Montefiore Medical Center Modified hemoglobin and its use as a component of an artificial blood substitute
US5843888A (en) * 1995-05-01 1998-12-01 Carnegie Mellon University Low oxygen affinity mutant hemoglobin
US5770404A (en) * 1995-06-14 1998-06-23 Camiener; Gerald W. Preparation of hemoproteins from apoproteins and heme-like porphyrins derived from chlorophyll
US6812207B1 (en) 1995-10-23 2004-11-02 William Marsh Rice University Hemoglobin mutants that reduce heme loss
JPH11514237A (ja) * 1995-10-23 1999-12-07 ライス ユニバーシティ ヘム損失を減少させるヘモグロビン変異体
JP2000502058A (ja) * 1995-11-30 2000-02-22 ソマトジェン，インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
US6218513B1 (en) 1995-12-22 2001-04-17 Baxter Biotech Technology Sarl Globins containing binding domains
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
AU4652797A (en) 1996-09-27 1998-04-17 Board Of Trustees Of The University Of Illinois, The Oxygen-binding heme proteins incorporating circularly-permuted globins
JP4583510B2 (ja) * 1997-02-28 2010-11-17 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 無細胞系による酸素輸送の最適化のための方法と組成物
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6455676B1 (en) 1997-05-02 2002-09-24 Baxter Biotech Technology Sarl Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
EP1950298A3 (de) 1997-05-02 2008-12-24 Baxter Biotech Technology S.A.R.L. Hämoglobinmutanten mit erhöhtem Löslichkeitswert und/oder reduzierter Stickoxidspülung
US5900402A (en) * 1997-05-29 1999-05-04 Enzon, Inc. Method of reducing side effects associated with administration of oxygen-carrying proteins
US6485450B1 (en) 1998-03-16 2002-11-26 Life Science Holdings, Inc. Brain resuscitation apparatus and method
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6780892B1 (en) 1998-10-01 2004-08-24 Temple University—Of the Commonwealth System of Higher Education Polymeric hemoglobin mutants
MXPA02001479A (es) * 1999-08-12 2003-07-21 Asafov Alexndr Vilenovich Solucion de reemplazo de plasma sanguineo.
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
JP5099951B2 (ja) * 1999-11-12 2012-12-19 バクスター・インターナショナル・インコーポレイテッド 副作用が減少されたヘモグロビン組成物
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
US6486123B1 (en) * 2000-06-21 2002-11-26 Carnegie Mellon University Low oxygen affinity mutant hemoglobins
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050119161A1 (en) * 2002-01-11 2005-06-02 Winslow Robert M. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
EP1894573A3 (de) 2002-01-11 2013-06-12 Sangart, Inc. Verfahren und Zusammensetzungen für den Sauerstofftransport mit hoher Sauerstoffaffinität
EP1469811A4 (de) * 2002-01-11 2006-01-04 Sangart Inc Verfahren und zusammensetzungen für den sauerstofftransport mit modifiziertem hämoglobin in plasma
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050287125A1 (en) * 2002-05-22 2005-12-29 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
JP2006516994A (ja) * 2003-01-29 2006-07-13 ノースフィールド ラボラトリーズ、インコーポレイテッド テトラマーの量を低下させた重合ヘモグロビン溶液及び調製するための方法
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WO2005041898A2 (en) * 2003-10-30 2005-05-12 Temple University Of The Commonwealth System Of Higher Education Blood substitutes
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US7642233B2 (en) * 2004-09-15 2010-01-05 William Marsh Rice University Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
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US20070166792A1 (en) * 2004-09-15 2007-07-19 Olson John S Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
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GB0712685D0 (en) 2007-06-29 2007-08-08 Wivenhoe Technology Ltd Improvements relating to oxygen-carrying proteins (2)
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US9845457B2 (en) * 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
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AU2014259617B2 (en) 2013-05-03 2019-04-11 Washington University Blood substitute composition and method of use
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (de) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center Kardiosphärenzellen und deren extrazelluläre vesikel zur verzögerung oder umkehr des alterungsprozesses und altersbedingten erkrankungen
CA3059910A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
JP2962731B2 (ja) * 1986-11-10 1999-10-12 バイオピュアー、コーポレーション 超純枠半合成代用血液

Also Published As

Publication number Publication date
JP3034529B2 (ja) 2000-04-17
AU614525B2 (en) 1991-09-05
GB8925769D0 (en) 1990-08-01
DE3851225D1 (de) 1994-09-29
JPH02503509A (ja) 1990-10-25
DE3851225T2 (de) 1995-04-06
GB2234749B (en) 1992-01-08
SG26593G (en) 1993-05-21
CA1341286C (en) 2001-08-28
US5028588A (en) 1991-07-02
AU1796788A (en) 1988-12-21
GB2234749A (en) 1991-02-13
EP0358708A4 (de) 1990-04-10
EP0358708A1 (de) 1990-03-21
HU211989A9 (en) 1996-01-29
WO1988009179A1 (en) 1988-12-01
EP0358708B1 (de) 1994-08-24
GB8711614D0 (en) 1987-06-24

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