ATE222600T1 - Expression von rekombinantem hämoglobin in hefe - Google Patents

Expression von rekombinantem hämoglobin in hefe

Info

Publication number
ATE222600T1
ATE222600T1 AT91908364T AT91908364T ATE222600T1 AT E222600 T1 ATE222600 T1 AT E222600T1 AT 91908364 T AT91908364 T AT 91908364T AT 91908364 T AT91908364 T AT 91908364T AT E222600 T1 ATE222600 T1 AT E222600T1
Authority
AT
Austria
Prior art keywords
yeast
hemoglobin
globin
heme
substantially homologous
Prior art date
Application number
AT91908364T
Other languages
English (en)
Inventor
Angelo Joseph De
Nalini M Motwani
Wajeeh Bajwa
Original Assignee
Apex Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apex Bioscience Inc filed Critical Apex Bioscience Inc
Application granted granted Critical
Publication of ATE222600T1 publication Critical patent/ATE222600T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
AT91908364T 1990-04-16 1991-04-15 Expression von rekombinantem hämoglobin in hefe ATE222600T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50991890A 1990-04-16 1990-04-16
US61435990A 1990-11-14 1990-11-14
US68461191A 1991-04-12 1991-04-12
PCT/US1991/002568 WO1991016349A1 (en) 1990-04-16 1991-04-15 Expression of recombinant hemoglobin in yeast

Publications (1)

Publication Number Publication Date
ATE222600T1 true ATE222600T1 (de) 2002-09-15

Family

ID=27414428

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91908364T ATE222600T1 (de) 1990-04-16 1991-04-15 Expression von rekombinantem hämoglobin in hefe

Country Status (11)

Country Link
EP (1) EP0537160B1 (de)
JP (1) JPH07504645A (de)
AT (1) ATE222600T1 (de)
AU (1) AU7744491A (de)
CA (1) CA2080589A1 (de)
DE (1) DE69133089T2 (de)
IE (1) IE911268A1 (de)
IL (1) IL97869A0 (de)
NZ (1) NZ237827A (de)
PT (1) PT97383B (de)
WO (1) WO1991016349A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US6150506A (en) * 1989-05-10 2000-11-21 Baxter Biotech Technology Sarl Modified hemoglobin-like compounds and methods of purifying same
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US5756295A (en) * 1994-12-05 1998-05-26 Takeda Chemical Industries, Ltd. DNA primer and a method for screening DNAS
US6812207B1 (en) 1995-10-23 2004-11-02 William Marsh Rice University Hemoglobin mutants that reduce heme loss
CA2231245A1 (en) * 1995-10-23 1997-05-01 Mark S. Hargrove Hemoglobin mutants that reduce heme loss
EP0863918A1 (de) * 1995-11-30 1998-09-16 Somatogen Inc. Verfahren zur kontrollierung der funktionalität während der vernetzung von hämoglobine
JP2000504934A (ja) 1995-12-22 2000-04-25 バクスター バイオテク テクノロジー エス．アー．アール．エル． 結合ドメインを含むグロビン
CN106456802B (zh) * 2014-01-30 2019-10-18 儿童医院医疗中心 一种改进的用于镰状细胞疾病基因校正的胎儿血红蛋白
WO2021022189A1 (en) * 2019-08-01 2021-02-04 The Regents Of The University Of California Compositions and methods for treating alpha thalassemia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
NL8403425A (nl) * 1984-11-09 1986-06-02 Stichting Gastransport Stromavrije hemoglobine-oplossing, werkwijze voor de bereiding daarvan en toepassing daarvan.
US4826957A (en) * 1985-07-12 1989-05-02 New York University Immunogenic recombinant yeast expression product and method for purifying it
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
NZ233642A (en) * 1989-05-10 1992-12-23 Somatogenetics Int Linked hemoglobin subunits, preparation by genetic engineering and linker assay
WO1991013158A1 (en) * 1990-02-28 1991-09-05 Delta Biotechnology Limited Protein production in yeast

Also Published As

Publication number Publication date
EP0537160A1 (de) 1993-04-21
DE69133089T2 (de) 2003-04-17
WO1991016349A1 (en) 1991-10-31
EP0537160B1 (de) 2002-08-21
EP0537160A4 (en) 1993-09-01
JPH07504645A (ja) 1995-05-25
CA2080589A1 (en) 1991-10-17
DE69133089D1 (de) 2002-09-26
IL97869A0 (en) 1992-06-21
IE911268A1 (en) 1991-10-23
PT97383A (pt) 1991-12-31
PT97383B (pt) 1998-08-31
AU7744491A (en) 1991-11-11
NZ237827A (en) 1994-03-25

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