ATE110387T1 - Hemmung von stoffwechselweg von 5-lipoxygenasen. - Google Patents

Hemmung von stoffwechselweg von 5-lipoxygenasen.

Info

Publication number: ATE110387T1
Authority: AT; Austria
Prior art keywords: lipoxygenases; metabolism; inhibition; lipoxygenase pathway; inhibiting
Prior art date: 1985-12-12

Application number

AT86309672T

Other languages

English (en)

Inventor

Paul Elliot Bender

Nabil Hanna

Henry Martin Sarau

John Gerald Gleason

Ivan Lantos

Don Edgar Griswold

Kazys Arunas Razgaitis

Susan Cathy Shilcrat

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-12

Filing date

1986-12-11

Publication date

1994-09-15

1986-04-28 Priority claimed from US06/856,928 external-priority patent/US4719218A/en

1986-12-11 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-09-15 Application granted granted Critical

1994-09-15 Publication of ATE110387T1 publication Critical patent/ATE110387T1/de

Links

230000005764 inhibitory process Effects 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 2
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
230000037361 pathway Effects 0.000 abstract 2
AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Fodder In General (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Organic Insulating Materials (AREA)
Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
Feed For Specific Animals (AREA)

AT86309672T 1985-12-12 1986-12-11 Hemmung von stoffwechselweg von 5-lipoxygenasen. ATE110387T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US80840785A	1985-12-12	1985-12-12
US80859585A	1985-12-12	1985-12-12
US85687586A	1986-04-28	1986-04-28
US06/856,928 US4719218A (en)	1985-12-12	1986-04-28	Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor

Publications (1)

Publication Number	Publication Date
ATE110387T1 true ATE110387T1 (de)	1994-09-15

Family

ID=27505832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86309672T ATE110387T1 (de)	1985-12-12	1986-12-11	Hemmung von stoffwechselweg von 5-lipoxygenasen.

Country Status (13)

Country	Link
EP (1)	EP0231622B1 (de)
AT (1)	ATE110387T1 (de)
AU (2)	AU609706B2 (de)
DE (1)	DE3650041T2 (de)
DK (1)	DK594086A (de)
ES (1)	ES2056789T3 (de)
FI (1)	FI865062A7 (de)
HU (1)	HU207077B (de)
IL (1)	IL80936A0 (de)
NO (1)	NO865011L (de)
NZ (1)	NZ218570A (de)
PT (1)	PT83916B (de)
ZW (1)	ZW24186A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5145858A (en) *	1985-12-12	1992-09-08	Smithkline Beecham Corp.	Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
MY103766A (en) *	1987-09-02	1993-09-30	Smithkline Beckman Corp	Pyrrolo[1,2-a]imidazole and imidazo[1,2-a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
GB8724566D0 (en) *	1987-10-20	1987-11-25	Roussel Lab Ltd	Chemical compounds
KR920702621A (ko) *	1989-06-13	1992-10-06	스튜어트 알. 슈터	단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제
EP0533837A4 (en) *	1990-06-12	1994-11-17	Smithkline Beecham Corp	Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases
US5670455A (en) *	1992-01-29	1997-09-23	E. I. Du Pont De Nemours And Company	Substituted phenylheterocyclic herbicides
US6358885B1 (en)	1992-01-29	2002-03-19	Mississippi State University	Substituted phenylheterocyclic herbicides
US5552422A (en) *	1995-01-11	1996-09-03	Merck Frosst Canada, Inc.	Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
DE10256881A1 (de) *	2002-12-05	2004-06-24	Beiersdorf Ag	Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
PA8595001A1 (es)	2003-03-04	2004-09-28	Pfizer Prod Inc	Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
RU2612958C2 (ru)	2011-07-13	2017-03-14	Ск Кемикалз Ко., Лтд.	2-пиридилзамещенные имидазолы в качестве ингибиторов alk5 и/или alk4

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL131034C (de) *	1964-05-11
NL164285C (nl) *	1968-01-09	1980-12-15	Rhone Poulenc Sa	Werkwijze ter bereiding van een farmaceutisch preparaat, dat een imidazoÿ2.1-bÿthiazoolderivaat bevat, de gevormde farmaceutische preparaten, alsmede werkwijze voor het bereiden van dit imidazoÿ2.1-bÿthiazoolderivaat.
GB1541321A (en) *	1976-03-10	1979-02-28	Metabio	2,3-dihydroimidazo(2,1-b)thiazole derivatives and process for their preparation
US4263311A (en) *	1976-09-27	1981-04-21	Smithkline Corporation	5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles
LU77703A1 (de) *	1977-07-07	1979-03-26	Ciba Geigy Ag	Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
US4153706A (en) *	1978-02-13	1979-05-08	Smithkline Corporation	6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles
US4175127A (en) *	1978-09-27	1979-11-20	Smithkline Corporation	Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
CA1185020A (en) *	1978-12-22	1985-04-02	Geert C. Dijkhuis	Convectron thermonuclear reactor and process
US4186205A (en) *	1979-01-08	1980-01-29	Smithkline Corporation	2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles
IL78834A (en) *	1985-05-23	1992-07-15	Smithkline Beckman Corp	2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines

1986
- 1986-12-08 ZW ZW241/86A patent/ZW24186A1/xx unknown
- 1986-12-09 NZ NZ218570A patent/NZ218570A/xx unknown
- 1986-12-10 DK DK594086A patent/DK594086A/da not_active Application Discontinuation
- 1986-12-10 IL IL80936A patent/IL80936A0/xx unknown
- 1986-12-10 HU HU865149A patent/HU207077B/hu not_active IP Right Cessation
- 1986-12-11 FI FI865062A patent/FI865062A7/fi not_active Application Discontinuation
- 1986-12-11 PT PT83916A patent/PT83916B/pt not_active IP Right Cessation
- 1986-12-11 ES ES86309672T patent/ES2056789T3/es not_active Expired - Lifetime
- 1986-12-11 EP EP86309672A patent/EP0231622B1/de not_active Expired - Lifetime
- 1986-12-11 AT AT86309672T patent/ATE110387T1/de active
- 1986-12-11 DE DE3650041T patent/DE3650041T2/de not_active Expired - Fee Related
- 1986-12-11 NO NO865011A patent/NO865011L/no unknown
- 1986-12-12 AU AU66455/86A patent/AU609706B2/en not_active Ceased
1991
- 1991-02-25 AU AU71367/91A patent/AU7136791A/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ218570A (en)	1989-08-29
EP0231622B1 (de)	1994-08-24
ZW24186A1 (en)	1987-07-08
HU207077B (en)	1993-03-01
FI865062A7 (fi)	1987-06-13
DE3650041T2 (de)	1995-06-01
DK594086D0 (da)	1986-12-10
IL80936A0 (en)	1987-08-31
PT83916A (en)	1987-01-01
AU6645586A (en)	1987-06-18
NO865011D0 (no)	1986-12-11
ES2056789T3 (es)	1994-10-16
AU7136791A (en)	1991-05-09
AU609706B2 (en)	1991-05-09
DK594086A (da)	1987-06-13
HUT47106A (en)	1989-01-30
NO865011L (no)	1987-06-15
FI865062A0 (fi)	1986-12-11
DE3650041D1 (de)	1994-09-29
EP0231622A3 (en)	1989-05-24
PT83916B (pt)	1989-05-12
EP0231622A2 (de)	1987-08-12

Publication	Publication Date	Title
DE3682711D1 (de)	1992-01-16	Als fungizide verwendbare heterocyclische verbindungen.
NL970016I1 (nl)	1997-06-02	Heterocyclische verbindingen.
NO861080L (no)	1986-09-22	Heterosykliske forbindelser.
DE3576339D1 (de)	1990-04-12	Heterocyclische verbindungen.
FI883750L (fi)	1989-02-14	Transdermal plaoster foer administrering av ett laekemedel.
DE3750140D1 (de)	1994-07-28	Inhibierung der interleukin-1-bildung durch monocyten und/oder makrophagen.
AU609706B2 (en)	1991-05-09	Inhibition of the 5-lipoxygenase pathway
DE3381069D1 (de)	1990-02-08	Feldeffekttransistor mit modulierter beweglichkeit.
NO872039D0 (no)	1987-05-15	Nitrogenholdige heterocykliske forbindelser.
DE3887544D1 (de)	1994-03-17	Beta-aminoethyl-substituierte Phenyl-Verbindungen, diese enthaltende entzündungshemmende oder analgetische Zusammensetzungen.
DE3682873D1 (de)	1992-01-23	Heterocyclische verbindungen.
FI860909A7 (fi)	1986-09-06	Heterocykliska foereningar.
FI853757A7 (fi)	1986-04-27	Benseenifuusioitu heterosyklinen yhdiste.
FI851351A7 (fi)	1985-10-05	Heterosyklisiä yhdisteitä.
FI852521A7 (fi)	1985-12-28	Heterobisyklisten yhdisteiden aryylijohdannaisia.
IT8521235A0 (it)	1985-06-21	Composti farmacologicamente attivi.
FI862431A7 (fi)	1986-12-09	1,1,2,2-tetrametyyli-1,2-bis -(2-fluori-4-hydroksi-fenyyli)-etaanin uudet johdannaiset.
DE3575720D1 (de)	1990-03-08	Heterocyclische verbindungen.
FI864642L (fi)	1987-05-16	Heterocykliska foereningar.
IT8619233A0 (it)	1986-01-30	Composti eterociclici.
DE3575718D1 (de)	1990-03-08	Bromodichlorimidazolderivate als insektizide.
ATE14125T1 (de)	1985-07-15	5-(4-phenyl-1-piperidinyl)methyl-2,3-dihydro-2oxo-1h-imidazol-4-carbonsaeure-derivate.
ATE70051T1 (de)	1991-12-15	Als fungizide verwendbare heterocyclische verbindungen.
FI864641L (fi)	1987-05-16	Heterocykliska foereningar.
FI874320A7 (fi)	1988-04-04	Orgaanisiin yhdisteisiin liittyviä parannuksia.