IL80936A0 - Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation - Google Patents

Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation

Info

Publication number
IL80936A0
IL80936A0 IL80936A IL8093686A IL80936A0 IL 80936 A0 IL80936 A0 IL 80936A0 IL 80936 A IL80936 A IL 80936A IL 8093686 A IL8093686 A IL 8093686A IL 80936 A0 IL80936 A0 IL 80936A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
lipoxygenase pathway
inhibition
compounds
preparation
Prior art date
Application number
IL80936A
Other languages
English (en)
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/856,928 external-priority patent/US4719218A/en
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Priority to IL80936A priority Critical patent/IL80936A0/xx
Publication of IL80936A0 publication Critical patent/IL80936A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Insulating Materials (AREA)
  • Vessels, Lead-In Wires, Accessory Apparatuses For Cathode-Ray Tubes (AREA)
  • Feed For Specific Animals (AREA)
IL80936A 1985-12-12 1986-12-10 Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation IL80936A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL80936A IL80936A0 (en) 1985-12-12 1986-12-10 Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80840785A 1985-12-12 1985-12-12
US80859585A 1985-12-12 1985-12-12
US85687586A 1986-04-28 1986-04-28
US06/856,928 US4719218A (en) 1985-12-12 1986-04-28 Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
IL80936A IL80936A0 (en) 1985-12-12 1986-12-10 Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation

Publications (1)

Publication Number Publication Date
IL80936A0 true IL80936A0 (en) 1987-08-31

Family

ID=27505832

Family Applications (1)

Application Number Title Priority Date Filing Date
IL80936A IL80936A0 (en) 1985-12-12 1986-12-10 Pharmaceutical compositions for inhibition of the 5-lipoxygenase pathway containing condensed imidazole derivatives,some new such compounds and their preparation

Country Status (13)

Country Link
EP (1) EP0231622B1 (de)
AT (1) ATE110387T1 (de)
AU (2) AU609706B2 (de)
DE (1) DE3650041T2 (de)
DK (1) DK594086A (de)
ES (1) ES2056789T3 (de)
FI (1) FI865062A7 (de)
HU (1) HU207077B (de)
IL (1) IL80936A0 (de)
NO (1) NO865011L (de)
NZ (1) NZ218570A (de)
PT (1) PT83916B (de)
ZW (1) ZW24186A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145858A (en) * 1985-12-12 1992-09-08 Smithkline Beecham Corp. Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
MY103766A (en) * 1987-09-02 1993-09-30 Smithkline Beckman Corp Pyrrolo[1,2-a]imidazole and imidazo[1,2-a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
GB8724566D0 (en) * 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
KR920702621A (ko) * 1989-06-13 1992-10-06 스튜어트 알. 슈터 단핵세포 및/또는 마크로파지에 의한 인터루킨-1 또는 종양회사인자 생성의 억제
EP0533837A4 (en) * 1990-06-12 1994-11-17 Smithkline Beecham Corp Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases
US5670455A (en) * 1992-01-29 1997-09-23 E. I. Du Pont De Nemours And Company Substituted phenylheterocyclic herbicides
US6358885B1 (en) 1992-01-29 2002-03-19 Mississippi State University Substituted phenylheterocyclic herbicides
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
DE10256881A1 (de) * 2002-12-05 2004-06-24 Beiersdorf Ag Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
RU2612958C2 (ru) 2011-07-13 2017-03-14 Ск Кемикалз Ко., Лтд. 2-пиридилзамещенные имидазолы в качестве ингибиторов alk5 и/или alk4

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131034C (de) * 1964-05-11
NL164285C (nl) * 1968-01-09 1980-12-15 Rhone Poulenc Sa Werkwijze ter bereiding van een farmaceutisch preparaat, dat een imidazoÿ2.1-bÿthiazoolderivaat bevat, de gevormde farmaceutische preparaten, alsmede werkwijze voor het bereiden van dit imidazoÿ2.1-bÿthiazoolderivaat.
GB1541321A (en) * 1976-03-10 1979-02-28 Metabio 2,3-dihydroimidazo(2,1-b)thiazole derivatives and process for their preparation
US4263311A (en) * 1976-09-27 1981-04-21 Smithkline Corporation 5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles
LU77703A1 (de) * 1977-07-07 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
US4153706A (en) * 1978-02-13 1979-05-08 Smithkline Corporation 6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
CA1185020A (en) * 1978-12-22 1985-04-02 Geert C. Dijkhuis Convectron thermonuclear reactor and process
US4186205A (en) * 1979-01-08 1980-01-29 Smithkline Corporation 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles
IL78834A (en) * 1985-05-23 1992-07-15 Smithkline Beckman Corp 2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines

Also Published As

Publication number Publication date
ATE110387T1 (de) 1994-09-15
NZ218570A (en) 1989-08-29
EP0231622B1 (de) 1994-08-24
ZW24186A1 (en) 1987-07-08
HU207077B (en) 1993-03-01
FI865062A7 (fi) 1987-06-13
DE3650041T2 (de) 1995-06-01
DK594086D0 (da) 1986-12-10
PT83916A (en) 1987-01-01
AU6645586A (en) 1987-06-18
NO865011D0 (no) 1986-12-11
ES2056789T3 (es) 1994-10-16
AU7136791A (en) 1991-05-09
AU609706B2 (en) 1991-05-09
DK594086A (da) 1987-06-13
HUT47106A (en) 1989-01-30
NO865011L (no) 1987-06-15
FI865062A0 (fi) 1986-12-11
DE3650041D1 (de) 1994-09-29
EP0231622A3 (en) 1989-05-24
PT83916B (pt) 1989-05-12
EP0231622A2 (de) 1987-08-12

Similar Documents

Publication Publication Date Title
IL80437A0 (en) Benzimidazole derivatives and pharmaceutical compositions containing them
NZ220841A (en) 1-azabicyclo compounds carbon substituted by a heterocyclic ring, and pharmaceutical compositions containing such
AU609706B2 (en) Inhibition of the 5-lipoxygenase pathway
NZ220650A (en) Tricyclic heterocyclic compounds and pharmaceutical compositions
IL108648A0 (en) Condensed five-membered heterocyclic compounds, their preparation and pharmaceutical compositions containing them
NZ220176A (en) Tricyclic heterocyclic compounds and pharmaceutical compositions
ATE2898T1 (de) Oxim-aether, ihre herstellung und diese enthaltende pharmazeutische praeparate.
HUT38915A (en) Process for preparing tricyclic dihydropiridazinone derivatives and pharmaceutical compositions containing such compounds as active substances
PT84716A (en) Process for the preparation of insecticidal compositions containing six-membered heterocyclic derivatives of n:-substituted-n,n:-diacylhydrazines
DE3164338D1 (en) Conjugated polyprenylcarboxylic acids and their derivatives as well as pharmaceutical preparations containing these compounds
NZ211960A (en) Benz(5,6)isoindolo(2,1-b)isoquinoline-8,13-dione derivatives and pharmaceutical compositions
IL75638A0 (en) Aryl derivatives of heterobicyclic compounds,their preparation and pharmaceutical compositions containing them
IT1194793B (it) Derivati tiazolidinici ad attivita' farmacologica,procedimento per la loro preparazione e composizioni farmaceutiche contenenti detti derivati
PT84718A (en) Process for the preparation of insecticidal compositions containing five-membered heterocyclic derivatives of n:-substituted-n,n:-diacylhydrazines
DK356985D0 (da) Imidazo(1,2-a)quinolinderivater samt fremgangsmaade til fremstilling afog laegemiddel indeholdende saadanne forbindelser
ZA866487B (en) Methylendioxyphenanthren-and stilben derivatives,processes for the preparation thereof and pharmaceutical compositions containing these compounds
IL91482A0 (en) Pharmaceutical compositions containing certain heterocyclic compounds
DE2964817D1 (en) Pharmaceutical compositions containing two beta-lactam derivatives
HUT38919A (en) Process for preparing benzazole derivatives and pharmaceutical compositions containing such compounds as active substances
NZ192520A (en) Hydantoin derivatives pharmaceutical compositions
IL91480A0 (en) Pharmaceutical compositions containing certain heterocyclic compounds
IL78537A0 (en) Substituted 2-(n-alkynyl-n-phenylamino)imidazoline derivatives,their preparation and pharmaceutical compositions containing them
DK181385D0 (da) Heterocycliske pyranoderivater, fremgangsmaade til fremstilling derafog laegemiddel indeholdende saadanne forbindelser
IL91481A0 (en) Pharmaceutical compositions containing certain heterocyclic compounds
IL86831A0 (en) Pharmaceutical compositions containing heterocyclic olefinic compounds,certain such compounds and their preparation