ATE11049T1 - Aktive pharmazeutische spirohydantoinderivate. - Google Patents

Aktive pharmazeutische spirohydantoinderivate.

Info

Publication number: ATE11049T1
Authority: AT; Austria
Prior art keywords: halogeno; alkyl; nitro; formula; independently selected
Prior art date: 1981-05-12

Application number

AT82302335T

Other languages

English (en)

Inventor

David Robert Brittain

Robin Wood

Original Assignee

Imperial Chemical Industries Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-12

Filing date

1982-05-07

Publication date

1985-01-15

1982-05-07 Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc

1985-01-15 Application granted granted Critical

1985-01-15 Publication of ATE11049T1 publication Critical patent/ATE11049T1/de

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
208000027472 Galactosemias Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Dental Preparations (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT82302335T 1981-05-12 1982-05-07 Aktive pharmazeutische spirohydantoinderivate. ATE11049T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8114399		1981-05-12
EP82302335A EP0066378B1 (de)	1981-05-12	1982-05-07	Aktive pharmazeutische Spirohydantoinderivate

Publications (1)

Publication Number	Publication Date
ATE11049T1 true ATE11049T1 (de)	1985-01-15

Family

ID=10521724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82302335T ATE11049T1 (de)	1981-05-12	1982-05-07	Aktive pharmazeutische spirohydantoinderivate.

Country Status (11)

Country	Link
US (1)	US4386100A (de)
EP (1)	EP0066378B1 (de)
JP (1)	JPS57192385A (de)
AT (1)	ATE11049T1 (de)
AU (1)	AU549265B2 (de)
CA (1)	CA1183142A (de)
DE (1)	DE3261751D1 (de)
IE (1)	IE52879B1 (de)
IL (1)	IL65603A0 (de)
NZ (1)	NZ200577A (de)
ZA (1)	ZA822792B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU566869B2 (en) *	1982-05-11	1987-11-05	Imperial Chemical Industries Plc	Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
US4464380A (en) *	1983-05-25	1984-08-07	Pfizer Inc.	Imidazolidinedione derivatives
WO1986000807A1 (en) *	1984-07-20	1986-02-13	Pfizer Inc.	Spiro-imidazolones for treatment of diabetes complications
US4911931A (en) *	1987-08-03	1990-03-27	Baylink David J	Pharmaceutical combination for treatment of bone-wasting diseases
US5071655A (en) *	1990-01-12	1991-12-10	Baylink David J	Pharmaceutical combination for treatment of bone-wasting diseases
US5068332A (en) *	1990-10-12	1991-11-26	American Home Products Corporation	Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) *	1990-10-12	1992-04-07	American Home Products Corporation	1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
KR101333861B1 (ko) *	2005-05-24	2013-11-28	메르크 세로노 에스. 에이.	Ｃｒｔｈ２ 조정자로서 삼환계 스피로 유도체
CN101415713A (zh) *	2006-02-07	2009-04-22	阿斯利康(瑞典)有限公司	用于治疗香草素受体1相关病症的新螺[咪唑烷-4,3’-吲哚]-2,2’,5(1’h)-三酮
AR059265A1 (es) *	2006-02-07	2008-03-19	Astrazeneca Ab	Compuestos espiro condensados con actividad inhibitoria en el receptor vaniloide1 (vr1)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
AU532110B2 (en) *	1979-11-13	1983-09-15	Ici Ltd.	Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives

1982
- 1982-04-20 IE IE929/82A patent/IE52879B1/en unknown
- 1982-04-21 AU AU82892/82A patent/AU549265B2/en not_active Ceased
- 1982-04-23 ZA ZA822792A patent/ZA822792B/xx unknown
- 1982-04-26 IL IL65603A patent/IL65603A0/xx not_active IP Right Cessation
- 1982-05-07 EP EP82302335A patent/EP0066378B1/de not_active Expired
- 1982-05-07 DE DE8282302335T patent/DE3261751D1/de not_active Expired
- 1982-05-07 AT AT82302335T patent/ATE11049T1/de not_active IP Right Cessation
- 1982-05-11 US US06/377,134 patent/US4386100A/en not_active Expired - Fee Related
- 1982-05-11 NZ NZ200577A patent/NZ200577A/en unknown
- 1982-05-11 CA CA000402674A patent/CA1183142A/en not_active Expired
- 1982-05-12 JP JP57078474A patent/JPS57192385A/ja active Pending

Also Published As

Publication number	Publication date
US4386100A (en)	1983-05-31
EP0066378B1 (de)	1985-01-02
IE52879B1 (en)	1988-03-30
IL65603A0 (en)	1982-11-30
NZ200577A (en)	1984-09-28
AU549265B2 (en)	1986-01-23
JPS57192385A (en)	1982-11-26
ZA822792B (en)	1983-02-23
CA1183142A (en)	1985-02-26
AU8289282A (en)	1982-11-18
DE3261751D1 (en)	1985-02-14
IE820929L (en)	1982-11-12
EP0066378A1 (de)	1982-12-08

Legal Events

Date	Code	Title	Description
1985-05-15	UEP	Publication of translation of european patent specification
1990-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3261751D1 (en)	1985-02-14	Pharmaceutical spiro-hydantoin derivatives
FI803539L (fi)	1981-05-14	Substituerade indolin-2-on derivater
DE3262529D1 (en)	1985-04-18	Pharmaceutical spiro-succinimide derivatives
EP0137993A3 (en)	1986-02-19	11-piperazinyl-5h-imidazoû2,1-c¨û1,4¨benzodiazepines, process for their preparation and intermediates and medicaments containing them
NO954317D0 (no)	1995-10-27	Pyrido(1,2,3-de)kinoksalinderivater, fremgangsmåte for deres fremstilling, og deres anvendelse i legemidler