IL65603A0 - Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL65603A0
IL65603A0 IL65603A IL6560382A IL65603A0 IL 65603 A0 IL65603 A0 IL 65603A0 IL 65603 A IL65603 A IL 65603A IL 6560382 A IL6560382 A IL 6560382A IL 65603 A0 IL65603 A0 IL 65603A0
Authority
IL
Israel
Prior art keywords
derivatives
halogeno
alkyl
nitro
pharmaceutical compositions
Prior art date
Application number
IL65603A
Other languages
English (en)
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of IL65603A0 publication Critical patent/IL65603A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL65603A 1981-05-12 1982-04-26 Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them IL65603A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8114399 1981-05-12

Publications (1)

Publication Number Publication Date
IL65603A0 true IL65603A0 (en) 1982-11-30

Family

ID=10521724

Family Applications (1)

Application Number Title Priority Date Filing Date
IL65603A IL65603A0 (en) 1981-05-12 1982-04-26 Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
US (1) US4386100A (de)
EP (1) EP0066378B1 (de)
JP (1) JPS57192385A (de)
AT (1) ATE11049T1 (de)
AU (1) AU549265B2 (de)
CA (1) CA1183142A (de)
DE (1) DE3261751D1 (de)
IE (1) IE52879B1 (de)
IL (1) IL65603A0 (de)
NZ (1) NZ200577A (de)
ZA (1) ZA822792B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU566869B2 (en) * 1982-05-11 1987-11-05 Imperial Chemical Industries Plc Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
WO1986000807A1 (en) * 1984-07-20 1986-02-13 Pfizer Inc. Spiro-imidazolones for treatment of diabetes complications
US4911931A (en) * 1987-08-03 1990-03-27 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
EP1891075B1 (de) * 2005-05-24 2011-10-19 Merck Serono SA Tricyclische spiroderivate als crth2-modulatoren
TW200801011A (en) 2006-02-07 2008-01-01 Astrazeneca Ab New compounds II
US20090076049A1 (en) * 2006-02-07 2009-03-19 Astrazeneca Ab Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
IE50332B1 (en) * 1979-11-13 1986-04-02 Ici Ltd 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
ATE11049T1 (de) 1985-01-15
AU8289282A (en) 1982-11-18
IE820929L (en) 1982-11-12
IE52879B1 (en) 1988-03-30
CA1183142A (en) 1985-02-26
ZA822792B (en) 1983-02-23
JPS57192385A (en) 1982-11-26
AU549265B2 (en) 1986-01-23
US4386100A (en) 1983-05-31
EP0066378A1 (de) 1982-12-08
NZ200577A (en) 1984-09-28
DE3261751D1 (en) 1985-02-14
EP0066378B1 (de) 1985-01-02

Similar Documents

Publication Publication Date Title
DE3069372D1 (en) 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof
IL65603A0 (en) Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them
AU561390B2 (en) Spiro (pyrolidine-3,3:-indoline)-2,2:,5-trione derivatives

Legal Events

Date Code Title Description
RH Patent void